INT95171

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 4.69
Pain Relevance 3.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
pores 3
visceral 1
neurons 1
afferent neurons 1
neck muscles 1
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 26 99.74 Very High Very High Very High
Pain 24 99.52 Very High Very High Very High
potassium channel 1 97.96 Very High Very High Very High
allodynia 9 97.76 Very High Very High Very High
Action potential 34 97.12 Very High Very High Very High
depression 2 96.28 Very High Very High Very High
adenocard 14 95.76 Very High Very High Very High
noradrenaline 2 94.84 High High
intrathecal 1 91.96 High High
dorsal root ganglion 31 91.48 High High
Disease Link Frequency Relevance Heat
Nociception 41 100.00 Very High Very High Very High
Pain 16 99.52 Very High Very High Very High
Neuropathic Pain 17 97.76 Very High Very High Very High
Schizophrenia 2 97.00 Very High Very High Very High
Depression 2 96.28 Very High Very High Very High
Disease 2 95.40 Very High Very High Very High
Neurodegenerative Disease 2 91.60 High High
Ganglion Cysts 31 91.00 High High
Cv Unclassified Under Development 2 90.48 High High
Enteropathy 1 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATP induces sustained facilitation of craniofacial nociception by prolonged excitation of P2X receptors in neck muscles.
P2X Binding (excitation) of in neck muscles associated with nociception
1) Confidence 0.36 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16686909 Disease Relevance 0.46 Pain Relevance 0.26
P2X receptors (7 types; P2X(1)-P2X(7)) contain intrinsic pores that open by binding with ATP.
P2X Binding (binding) of in pores
2) Confidence 0.31 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697046 Disease Relevance 0 Pain Relevance 0
In the present study, we investigated the interaction of purinoceptor P2X and the PGF(2 alpha) receptor (FP) in the induction of allodynia by use of mice lacking FP (FP(-/-)).
P2X Binding (interaction) of associated with allodynia
3) Confidence 0.26 Published 2009 Journal Neuroscience Section Abstract Doc Link 19490931 Disease Relevance 0.65 Pain Relevance 1.13
The potential importance for nociception of P2X receptors, the ionotropic receptors activated by ATP, is underscored by the variety of pain states in which this endogenous ligand can be released.
P2X Binding (nociception) of associated with nociception and pain
4) Confidence 0.23 Published 2001 Journal Pharmacol. Rev. Section Abstract Doc Link 11734618 Disease Relevance 0.47 Pain Relevance 0.18
This article reviews the role of purinergic signalling in CNS disorders, highlighting specific purinergic receptor subtypes, most notably A(2A), P2X(4) and P2X(7), that might be therapeutically targeted for the treatment of these conditions.
P2X Spec (might) Binding (highlighting) of
5) Confidence 0.22 Published 2008 Journal Nat Rev Drug Discov Section Abstract Doc Link 18591979 Disease Relevance 0.56 Pain Relevance 0.09
This article reviews the role of purinergic signalling in CNS disorders, highlighting specific purinergic receptor subtypes, most notably A(2A), P2X(4) and P2X(7), that might be therapeutically targeted for the treatment of these conditions.
P2X Spec (might) Binding (highlighting) of
6) Confidence 0.22 Published 2008 Journal Nat Rev Drug Discov Section Abstract Doc Link 18591979 Disease Relevance 0.56 Pain Relevance 0.09
P2X receptors (7 types; P2X(1) - P2X(7)) contain intrinsic pores that open by binding with ATP.
P2X Binding (binding) of in pores
7) Confidence 0.22 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18563292 Disease Relevance 0.05 Pain Relevance 0.05
Increased 5-HT3-mediated signalling in pelvic afferent neurons from mice deficient in P2X2 and/or P2X3 receptor subunits

Extracellular ATP and 5-hydroxytryptamine (5-HT) are both involved in visceral sensory pathways by interacting with P2X and 5-HT3 receptors, respectively.

P2X Binding (interacting) of in visceral
8) Confidence 0.22 Published 2006 Journal Purinergic Signal Section Title Doc Link PMC2096651 Disease Relevance 0.56 Pain Relevance 0.31
P2X receptors (7 types; P2X(1) - P2X(7)) contain intrinsic pores that open by binding with ATP.
P2X Binding (binding) of in pores
9) Confidence 0.19 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18563292 Disease Relevance 0.05 Pain Relevance 0.05
In order to test the hypothesis that the more prolonged rise times of sDeps indicate a lower peak current after ATP binding to P2X1 receptors, the rising phases of both sDeps and sAPs were differentiated and compared.
P2X1 Binding (binding) of
10) Confidence 0.18 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0
To assess the inward current through P2X1 receptors, the differentiated rising phases of only sDeps, pre- and post-superfusion with nifedipine (1 ?
P2X1 Binding (receptors) of
11) Confidence 0.18 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0.05 Pain Relevance 0.03
P2X receptors and their expression on primary afferent neurons
P2X Binding (receptors) of in afferent neurons
12) Confidence 0.17 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096570 Disease Relevance 0.10 Pain Relevance 0.10
This convergence may suggest that this ATP-sensitive/capsaicin-insensitive P2X purinergic pathway has interaction with nociceptive input.
P2X Binding (interaction) of associated with nociception and qutenza
13) Confidence 0.15 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096570 Disease Relevance 0.41 Pain Relevance 0.74
Only the rat but not the mouse neurons, however, possess P2X receptors which, when activated, mediate cation entry, depolarization, action potential generation and transmitter release.
P2X Binding (possess) of in neurons associated with action potential
14) Confidence 0.10 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311803 Disease Relevance 0 Pain Relevance 0.43
Studies in rodents have shown a significant involvement of adenosine in the control of intestinal secretion, motility and sensation, via activation of A1, A2A, A2B or A3 purinergic receptors, as well as the participation of ATP in the regulation of enteric functions, through the recruitment of P2X and P2Y receptors.
P2X Binding (recruitment) of associated with adenocard
15) Confidence 0.09 Published 2008 Journal Pharmacol. Ther. Section Abstract Doc Link 18848843 Disease Relevance 0.62 Pain Relevance 0.46

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