INT95172

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 14
Total Number 16
Disease Relevance 6.77
Pain Relevance 7.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
neuronal 3
neurons 3
brain 2
visceral 1
colon 1
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 45 100.00 Very High Very High Very High
ischemia 31 100.00 Very High Very High Very High
gABA 20 100.00 Very High Very High Very High
Action potential 7 100.00 Very High Very High Very High
Cancer pain 3 99.54 Very High Very High Very High
Neuronal nitric oxide synthase 6 99.28 Very High Very High Very High
Spinal cord 23 98.72 Very High Very High Very High
potassium channel 1 97.64 Very High Very High Very High
Central nervous system 35 97.48 Very High Very High Very High
Neuropathic pain 9 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 23 100.00 Very High Very High Very High
Cancer Pain 3 99.54 Very High Very High Very High
Nociception 13 99.08 Very High Very High Very High
Death 7 97.28 Very High Very High Very High
Neuropathic Pain 32 96.56 Very High Very High Very High
Hypoxia 4 96.44 Very High Very High Very High
INFLAMMATION 16 96.40 Very High Very High Very High
Injury 7 95.72 Very High Very High Very High
Nervous System Injury 4 95.44 Very High Very High Very High
Skin Cancer 4 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This latter suggestion is consistent with data showing localization of P2X3, P2X5 and P2X7 receptors to the longitudinal muscle of the canine colon (Lee et al., 2005).
Localization (localization) of P2X in colon
1) Confidence 0.78 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.16 Pain Relevance 0.06
The localization of P2Y(1), P2Y(2), P2Y(4), P2X(1) and P2X(2) receptors and neuronal nitric oxide synthase (NOS) were examined immunohistochemically, and P2Y(1) mRNA was examined with in situ hybridization.
Spec (examined) Localization (localization) of P2X in neuronal associated with neuronal nitric oxide synthase
2) Confidence 0.78 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527481 Disease Relevance 0 Pain Relevance 0.34
The localization of P2Y(1), P2Y(2), P2Y(4), P2X(1) and P2X(2) receptors and neuronal nitric oxide synthase (NOS) were examined immunohistochemically, and P2Y(1) mRNA was examined with in situ hybridization.
Spec (examined) Localization (localization) of P2X in neuronal associated with neuronal nitric oxide synthase
3) Confidence 0.78 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527481 Disease Relevance 0 Pain Relevance 0.34
These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons.
Localization (release) of P2X in skin associated with cancer pain
4) Confidence 0.70 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.11 Pain Relevance 0.39
ATP-sensitive P2X(7) receptors are localized on cells of immunological origin including glial cells in the central nervous system.
Localization (localized) of P2X in central nervous system associated with central nervous system
5) Confidence 0.68 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16982702 Disease Relevance 0.35 Pain Relevance 0.34
Furthermore, ATP stimulation is unable to stimulate BDNF release from P2X(4)-deficient mice microglia in primary cultures.
Localization (release) of P2X in microglia
6) Confidence 0.59 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971468 Disease Relevance 0.81 Pain Relevance 0.87
Immunostaining of beta-galactosidase, a reporter knocked into the endogenous FP locus in FP(-/-) mice, showed that the FP receptor was co-localized with P2X(2) and P2X(3) receptors in neurons of the spinal cord. alphabeta-Methylene ATP evoked a transient or sustained [Ca(2+)](i) increase in most of the PGF(2 alpha)-responsive cells in the deeper layer of the spinal cord, and the alphabeta-methylene ATP-evoked increase was blocked by the FP receptor antagonist AL-8810 in two-thirds of the cells.
Localization (localized) of P2X in neurons associated with antagonist and spinal cord
7) Confidence 0.53 Published 2009 Journal Neuroscience Section Abstract Doc Link 19490931 Disease Relevance 0.58 Pain Relevance 1.08
Immunostaining of beta-galactosidase, a reporter knocked into the endogenous FP locus in FP(-/-) mice, showed that the FP receptor was co-localized with P2X(2) and P2X(3) receptors in neurons of the spinal cord. alphabeta-Methylene ATP evoked a transient or sustained [Ca(2+)](i) increase in most of the PGF(2 alpha)-responsive cells in the deeper layer of the spinal cord, and the alphabeta-methylene ATP-evoked increase was blocked by the FP receptor antagonist AL-8810 in two-thirds of the cells.
Localization (localized) of P2X in neurons associated with antagonist and spinal cord
8) Confidence 0.53 Published 2009 Journal Neuroscience Section Abstract Doc Link 19490931 Disease Relevance 0.58 Pain Relevance 1.08
Furthermore, the release of ATP and P2X receptor-mediated afferent activation appear to have been implicated in visceral and neuropathic pain; the importance of the ATPergic component in these states needs to be investigated further.
Localization (release) of P2X in visceral associated with neuropathic pain
9) Confidence 0.43 Published 2001 Journal Pharmacol. Rev. Section Abstract Doc Link 11734618 Disease Relevance 0.77 Pain Relevance 0.47
Homomeric P2X(3) and heteromeric P2X(2/3) receptors are highly localised in the peripheral sensory afferent neurons that conduct nociceptive sensory information to the spinal chord and brain.
Localization (localised) of P2X in brain associated with nociception
10) Confidence 0.40 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.49 Pain Relevance 0.33
Homomeric P2X(3) and heteromeric P2X(2/3) receptors are highly localised in the peripheral sensory afferent neurons that conduct nociceptive sensory information to the spinal chord and brain.
Localization (localised) of P2X in brain associated with nociception
11) Confidence 0.40 Published 2006 Journal Expert Opin Ther Pat Section Abstract Doc Link 20144056 Disease Relevance 0.49 Pain Relevance 0.33
These data suggest that ATP and UTP cause a decrease in systemic arterial pressure in the mouse via a cAMP-dependent pathway via a novel P2 receptor linked to adenylate cyclase and that nitric oxide release, prostaglandin synthesis, cGMP, and P2X1, P2Y1, and P2Y4 receptors play little or no role in the vascular effects of these purinergic agonists in the mouse.
Localization (release) of P2X1 associated with agonist
12) Confidence 0.38 Published 2002 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11743236 Disease Relevance 0 Pain Relevance 0.39
Of all the P2X subunits, only P2X6 and P2X7 colocalized with DCX in the SVZ (Tab. 2).
Localization (colocalized) of P2X
13) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.19 Pain Relevance 0.03
Only the rat but not the mouse neurons, however, possess P2X receptors which, when activated, mediate cation entry, depolarization, action potential generation and transmitter release.
Localization (release) of P2X in neurons associated with action potential
14) Confidence 0.19 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311803 Disease Relevance 0 Pain Relevance 0.43
P2X receptor-mediated, TTX-sensitive GABA release has been implicated in the accelerated recovery of guinea pig hippocampal slices from a hypoxic/hypoglycemic insult [158].
Localization (release) of P2X receptor associated with gaba and hypoxia
15) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.10 Pain Relevance 0.79
Increased activation of P2X receptors could contribute to ischemia-evoked glutamate release and thereby to glutamatergic excitotoxicity and resultant neuronal death; therefore, inhibition of these receptors could be a promising approach to treat ischemia-related neurodegenerative diseases.
Localization (release) of P2X in neuronal associated with glutamate, ischemia, neurodegenerative disease and death
16) Confidence 0.17 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 1.02 Pain Relevance 0.55

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