INT952

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Context Info
Confidence 0.56
First Reported 1979
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 57
Total Number 60
Disease Relevance 25.30
Pain Relevance 10.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH) extracellular region (GHRH) cell-cell signaling (GHRH)
Anatomy Link Frequency
pituitary 5
plasma 3
testis 2
aorta 1
brain 1
GHRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 70 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
noradrenaline 3 100.00 Very High Very High Very High
antagonist 29 99.96 Very High Very High Very High
Chronic low back pain 96 99.84 Very High Very High Very High
Somatostatin 26 99.72 Very High Very High Very High
narcan 4 99.10 Very High Very High Very High
Pain 101 98.64 Very High Very High Very High
agonist 30 98.32 Very High Very High Very High
Endogenous opioid 3 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Growth Hormone Deficiency 66 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 3 100.00 Very High Very High Very High
Adenoma 3 100.00 Very High Very High Very High
Stress 128 99.98 Very High Very High Very High
Low Back Pain 128 99.84 Very High Very High Very High
Growth Problems 231 99.62 Very High Very High Very High
Obesity 76 99.58 Very High Very High Very High
Hypopituitarism 7 99.58 Very High Very High Very High
Hypoglycemia 28 99.56 Very High Very High Very High
Celiac Disease 65 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A SRIH hypertone, a GHRH deficiency or a functional failure of the somatotrope have been proposed as contributing factors.
Negative_regulation (deficiency) of GHRH in somatotrope associated with somatostatin
1) Confidence 0.56 Published 1999 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 10193871 Disease Relevance 0.90 Pain Relevance 0.05
Octreotide injection for 4 years efficaciously reduced the size of remnant adenoma as well as serum growth hormone levels.
Negative_regulation (reduced) of serum growth hormone associated with adenoma
2) Confidence 0.51 Published 2004 Journal Endocr. J. Section Abstract Doc Link 15516776 Disease Relevance 0.87 Pain Relevance 1.07
In the early 1960s, growth hormone (GH) deficiency was treated by intramuscular injection of GH extracted from human pituitary glands.
Negative_regulation (deficiency) of growth hormone in pituitary glands
3) Confidence 0.44 Published 2001 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 11393569 Disease Relevance 0.07 Pain Relevance 0.07
Hormone responses to intravenous sermorelin 1 microg/kg bodyweight appear to be a rapid and relatively specific test for the diagnosis of growth hormone deficiency.
Negative_regulation (deficiency) of growth hormone associated with growth hormone deficiency
4) Confidence 0.43 Published 1999 Journal BioDrugs Section Abstract Doc Link 18031173 Disease Relevance 0.46 Pain Relevance 0
However, normal growth hormone responses to intravenous sermorelin cannot exclude growth hormone deficiency due to a hypothalamic deficit: subnormal growth hormone response to other provocative tests is needed to confirm the presence of disease in these patients.
Negative_regulation (deficiency) of growth hormone associated with disease and growth hormone deficiency
5) Confidence 0.43 Published 1999 Journal BioDrugs Section Abstract Doc Link 18031173 Disease Relevance 0.61 Pain Relevance 0
A multicenter randomized trial of human growth hormone treatment was carried out in 121 children with short stature who did not meet the classic criteria for growth hormone deficiency.
Negative_regulation (deficiency) of growth hormone associated with growth hormone deficiency and growth problems
6) Confidence 0.43 Published 1989 Journal J. Pediatr. Section Abstract Doc Link 2681637 Disease Relevance 0.33 Pain Relevance 0
The heptapeptide growth hormone-releasing peptide-1 (GHRP-1), one of a series of recently synthesized small growth hormone (GH)-releasing peptides, was administered as an iv bolus (1 microgram/kg) to 15 (six prepubertal, nine pubertal) short but healthy children and adolescents and to eight juvenile patients with pituitary insufficiency (four with isolated growth hormone deficiency, two with multiple pituitary hormone deficiencies, one with partial GH deficiency and one with GH-releasing hormone (GHRH) deficiency).
Negative_regulation (deficiency) of growth hormone in pituitary associated with growth hormone deficiency and hypopituitarism
7) Confidence 0.42 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8279223 Disease Relevance 0.20 Pain Relevance 0
With chronic therapy, 24-h mean levels were significantly suppressed, and the GH stimulability of thyrotrophin-releasing hormone and growth-hormone-releasing hormone (pl-44) was markedly reduced.
Negative_regulation (reduced) of growth-hormone-releasing hormone
8) Confidence 0.42 Published 1986 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2876499 Disease Relevance 0.25 Pain Relevance 0.13
A second injection of either TRH or hpGRF failed to increase the GH concentration in immature chicks when administered 15, 30, or 60 min after the first injection.
Negative_regulation (injection) of hpGRF
9) Confidence 0.42 Published 1985 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3926599 Disease Relevance 0 Pain Relevance 0
The magnitude of the GH responses to TRH were, however, diminished by 83.3 and 26.7% when given 120 or 240 min after the initial TRH injection, and the responses to hpGRF were similarly reduced by 68.3 and 33.6%.
Negative_regulation (reduced) of hpGRF
10) Confidence 0.42 Published 1985 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3926599 Disease Relevance 0 Pain Relevance 0
The heptapeptide growth hormone-releasing peptide-1 (GHRP-1), one of a series of recently synthesized small growth hormone (GH)-releasing peptides, was administered as an iv bolus (1 microgram/kg) to 15 (six prepubertal, nine pubertal) short but healthy children and adolescents and to eight juvenile patients with pituitary insufficiency (four with isolated growth hormone deficiency, two with multiple pituitary hormone deficiencies, one with partial GH deficiency and one with GH-releasing hormone (GHRH) deficiency).
Negative_regulation (deficiency) of GHRH in pituitary associated with growth hormone deficiency and hypopituitarism
11) Confidence 0.41 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8279223 Disease Relevance 0.25 Pain Relevance 0.05
The heptapeptide growth hormone-releasing peptide-1 (GHRP-1), one of a series of recently synthesized small growth hormone (GH)-releasing peptides, was administered as an iv bolus (1 microgram/kg) to 15 (six prepubertal, nine pubertal) short but healthy children and adolescents and to eight juvenile patients with pituitary insufficiency (four with isolated growth hormone deficiency, two with multiple pituitary hormone deficiencies, one with partial GH deficiency and one with GH-releasing hormone (GHRH) deficiency).
Negative_regulation (deficiency) of GH-releasing hormone in pituitary associated with growth hormone deficiency and hypopituitarism
12) Confidence 0.41 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8279223 Disease Relevance 0.25 Pain Relevance 0.05
She responded normally to infusions of GHRH (GH rose to 22 ng/ml (22 micrograms/L) at 75 minutes) and TRH (TSH rose to 37 mu u/ml, 37 mIU/L).
Negative_regulation (infusions) of GHRH
13) Confidence 0.41 Published 1994 Journal Am. J. Med. Genet. Section Abstract Doc Link 7810565 Disease Relevance 0.68 Pain Relevance 0.10
In contrast, we found an almost complete blockade of GH response to either GHRP-6 or GHRH plus GHRP-6 in patients with pituitary stalk transection, suggesting that this could be a cost-effective test for the diagnosis of this condition.
Negative_regulation (blockade) of GHRH in pituitary stalk
14) Confidence 0.41 Published 1996 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 8887178 Disease Relevance 0.43 Pain Relevance 0.08
Our study further draws the attention on difference in attenuation of GRF in two types of homogenous CLBP population for future studies (p < 0.10) and provides evidence for attenuated GRF can be improved using core stability exercises in CLBP (Figure 2, 3, 4 and 5).
Negative_regulation (attenuated) of GRF associated with chronic low back pain
15) Confidence 0.41 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2903540 Disease Relevance 0.53 Pain Relevance 0.53
An experimental study reported significant attenuation in GRF in CLBP population walked at their preferred speed but not at fastest speed while comparing with pain free counterparts [35].
Negative_regulation (attenuation) of GRF associated with pain and chronic low back pain
16) Confidence 0.41 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2903540 Disease Relevance 0.49 Pain Relevance 0.49
Growth hormone response to clonidine is impaired in patients with central sympathetic degeneration.
Negative_regulation (impaired) of Growth hormone in sympathetic associated with clonidine
17) Confidence 0.41 Published 1984 Journal Clin Exp Hypertens A Section Title Doc Link 6398141 Disease Relevance 0.08 Pain Relevance 0.31
However, propranolol pretreatment doubled the GH responses to both GHRH and GHRP compared with those to GHRH or GHRP alone 28 +/- 5 micrograms/L vs. 14 +/- 5 (P less than 0.05) and 54 +/- 2 vs. 25 +/- 6 micrograms/L (P less than 0.001), respectively].
Negative_regulation (doubled) of GHRH
18) Confidence 0.41 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1856262 Disease Relevance 0 Pain Relevance 0.22
In addition to testosterone, the essential paracrine factor for spermatogenesis, a number of potential auto/paracrine regulatory substances such as beta-endorphins, enkephalins, chorionic gonadotropin beta, growth hormone-releasing hormone (GHRH) and insulin-like growth factor I (IGF-I) have been identified in the testis of various mammalian species.
Negative_regulation (number) of GHRH in testis associated with enkephalin
19) Confidence 0.40 Published 1997 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 9220021 Disease Relevance 0 Pain Relevance 0.10
Twenty patients, 10 patients in each of 2 groups, with adult-onset, growth hormone deficiency were treated for 1 month with recombinant human growth hormone (0.25 U/kg/week) or placebo.
Negative_regulation (deficiency) of growth hormone associated with growth hormone deficiency
20) Confidence 0.40 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7537355 Disease Relevance 0.10 Pain Relevance 0.26

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