INT95226

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.62
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (AHSA1) cytosol (AHSA1) endoplasmic reticulum (AHSA1)
response to stress (AHSA1) cytoplasm (AHSA1)
Anatomy Link Frequency
stroma 1
stem 1
T-lymphocytes 1
AHSA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 3 99.78 Very High Very High Very High
Morphine 8 99.68 Very High Very High Very High
Inflammation 10 97.12 Very High Very High Very High
cINOD 6 92.24 High High
imagery 28 5.00 Very Low Very Low Very Low
Central nervous system 17 5.00 Very Low Very Low Very Low
Action potential 8 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 12 98.28 Very High Very High Very High
Adenomatous Polyps 6 98.28 Very High Very High Very High
INFLAMMATION 10 97.12 Very High Very High Very High
Hepatitis C Virus Infection 8 96.76 Very High Very High Very High
Adenoma 3 96.56 Very High Very High Very High
Hemiplegia 58 91.00 High High
Disease 9 76.04 Quite High
Hepatitis 3 75.00 Quite High
Infection 17 74.32 Quite High
Cerebral Palsy 41 56.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the expression of the active forms of NF-kappaB, JNK and p38 MAPK using immunohistochemistry with activation specific antibodies in human colonic adenomas.
Spec (investigated) Gene_expression (expression) of p38 associated with adenoma
1) Confidence 0.49 Published 2001 Journal Oncogene Section Abstract Doc Link 11314016 Disease Relevance 0.86 Pain Relevance 0.22
NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps.
Gene_expression (expressed) of p38 in stroma associated with cox2 and adenomatous polyps
2) Confidence 0.49 Published 2001 Journal Oncogene Section Title Doc Link 11314016 Disease Relevance 0.84 Pain Relevance 0.32
We show that active NF-kappaB is seen in stromal macrophages that also express COX-2 and TNF-alpha, active JNK is seen in stromal and intraepithelial T-lymphocytes and periendothelial cells of new blood vessels, and active p38 MAPK is most highly expressed in macrophages and other stromal cells.
Gene_expression (expressed) of p38 in T-lymphocytes
3) Confidence 0.49 Published 2001 Journal Oncogene Section Abstract Doc Link 11314016 Disease Relevance 0.82 Pain Relevance 0.28
In addition, morphine suppressed the expression of p38, an important signal-transducing molecule involved in IFN- alpha -mediated anti-HCV activity.
Gene_expression (expression) of p38 associated with hepatitis c virus infection and morphine
4) Confidence 0.21 Published 2007 Journal J. Infect. Dis. Section Abstract Doc Link 17674315 Disease Relevance 0.81 Pain Relevance 0.71
Initially termed p38, PCBP was found to interact with stem-loop IV of the PV IRES.
Gene_expression (termed) of p38 in stem
5) Confidence 0.05 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0 Pain Relevance 0
Bimanual performance will be assessed using the AHA.
Gene_expression (using) of AHA
6) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2832893 Disease Relevance 0.14 Pain Relevance 0
Assisting Hand Assessment (AHA)
Gene_expression (Assisting) of AHA
7) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2832893 Disease Relevance 0.15 Pain Relevance 0

General Comments

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