INT95232

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.41
Pain Relevance 5.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (Aanat) cytoplasm (Aanat)
Anatomy Link Frequency
brain 4
neuronal 1
Aanat (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 106 100.00 Very High Very High Very High
Dopamine 38 99.80 Very High Very High Very High
cocaine 178 99.72 Very High Very High Very High
fluoxetine 12 99.08 Very High Very High Very High
antidepressant 16 98.86 Very High Very High Very High
Neurotransmitter 18 94.16 High High
Hippocampus 10 94.12 High High
Glutamate 4 92.76 High High
depression 12 92.24 High High
addiction 16 86.52 High High
Disease Link Frequency Relevance Heat
Helminth Infection 56 99.56 Very High Very High Very High
Depression 12 92.24 High High
Drug Dependence 14 86.52 High High
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Paralysis 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Nicotine Addiction 2 5.00 Very Low Very Low Very Low
Poisoning 2 5.00 Very Low Very Low Very Low
Alcohol Addiction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we investigated whether AANAT mRNA is expressed in the brain of C57BL/6J and C3H/HeJ mice and whether those mice differ behaviorally, i.e., in a forced swimming test which is used to evaluate antidepressant drugs (such drugs shorten the time of immobility).
Gene_expression (expressed) of AANAT in brain associated with antidepressant
1) Confidence 0.68 Published 2001 Journal J. Pineal Res. Section Abstract Doc Link 11316327 Disease Relevance 0.16 Pain Relevance 0.45
AANAT mRNA is expressed in the pineal gland and retina, and also in the rat brain.
Gene_expression (expressed) of AANAT in brain
2) Confidence 0.68 Published 2001 Journal J. Pineal Res. Section Abstract Doc Link 11316327 Disease Relevance 0.07 Pain Relevance 0.38
We found that C3H/HeJ mice express in the brain normal AANAT mRNA, whereas C57BL/6J mice express mutated AANAT mRNA.
Gene_expression (express) of AANAT in brain
3) Confidence 0.68 Published 2001 Journal J. Pineal Res. Section Abstract Doc Link 11316327 Disease Relevance 0.17 Pain Relevance 0.46
We found that C3H/HeJ mice express in the brain normal AANAT mRNA, whereas C57BL/6J mice express mutated AANAT mRNA.
Gene_expression (express) of AANAT in brain
4) Confidence 0.68 Published 2001 Journal J. Pineal Res. Section Abstract Doc Link 11316327 Disease Relevance 0.17 Pain Relevance 0.45
Repeated but not single treatment with either drug increased serotonin N-acetyltransferase expression in all areas tested.
Gene_expression (expression) of serotonin N-acetyltransferase associated with serotonin
5) Confidence 0.56 Published 2005 Journal Neuroscience Section Abstract Doc Link 15994025 Disease Relevance 0.07 Pain Relevance 0.81
In this study in mice, we investigated the delayed effects of single and repeated (i.e. 14 days) administration of the antidepressant fluoxetine and the psychostimulant cocaine on the brain expression of clock genes Period1, Period2, Period3, Clock, Bmal1, Cryptochrome1, Cryptochrome2, and NPAS2 (neuronal PAS domain protein 2), and their putative target gene, serotonin N-acetyltransferase.
Gene_expression (expression) of serotonin N-acetyltransferase in neuronal associated with antidepressant, serotonin, cocaine and fluoxetine
6) Confidence 0.49 Published 2005 Journal Neuroscience Section Abstract Doc Link 15994025 Disease Relevance 0.09 Pain Relevance 0.75
These include bas-1 (which encodes an aromatic amino acid decarboxylase (AADC) required for the production of serotonin and dopamine) [27], tdc-1 (which encodes an aromatic-L-amino-acid/L-histidine decarboxylase required for making tyramine and octopamine) [26], and eat-4 (which encodes a vesicular glutamate transporter important for glutamate-mediated neurotransmission) [28].
Gene_expression (production) of serotonin associated with glutamate, dopamine and serotonin
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691951 Disease Relevance 0.25 Pain Relevance 0.86
By contrast, tph-1 mutant worms, which are devoid of serotonin synthesis, lacked the hypolocomotor response to cocaine (Figure 3), indicating that serotonin is required for this cocaine response.
Gene_expression (synthesis) of serotonin associated with helminth infection, serotonin and cocaine
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691951 Disease Relevance 0.43 Pain Relevance 1.20

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