INT95233

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (Aanat) cytoplasm (Aanat)
Aanat (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 7 100.00 Very High Very High Very High
Hippocampus 1 99.36 Very High Very High Very High
cocaine 2 98.76 Very High Very High Very High
depression 3 98.32 Very High Very High Very High
fluoxetine 2 97.00 Very High Very High Very High
antidepressant 3 96.56 Very High Very High Very High
Dopamine 3 83.40 Quite High
Disease Link Frequency Relevance Heat
Depression 3 98.32 Very High Very High Very High
Cognitive Disorder 1 92.00 High High
Targeted Disruption 2 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, AANAT deficiency might be involved in the pathobiology of depression.
Negative_regulation (deficiency) of AANAT associated with depression
1) Confidence 0.43 Published 2001 Journal J. Pineal Res. Section Abstract Doc Link 11316327 Disease Relevance 0.10 Pain Relevance 0.45
Treatments with High dose psychostimulants that block DAT as well as the norepinephrine (NET) and serotonin (SERT) transporters (60 mg/kg cocaine or methylphenidate) significantly impaired PPI in wild-type mice.
Negative_regulation (block) of serotonin associated with serotonin and cocaine
2) Confidence 0.02 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16407898 Disease Relevance 0.25 Pain Relevance 0.36

General Comments

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