INT9525

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1991
Last Reported 2010
Negated 3
Speculated 6
Reported most in Abstract
Documents 20
Total Number 26
Disease Relevance 7.82
Pain Relevance 16.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
neurons 4
spinal cord 2
amygdala 2
vas deferens 2
F11 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 292 100.00 Very High Very High Very High
nMDA receptor 118 100.00 Very High Very High Very High
Spinal cord 73 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
Nucleus accumbens 6 100.00 Very High Very High Very High
withdrawal 143 99.98 Very High Very High Very High
qutenza 93 99.84 Very High Very High Very High
noradrenaline 9 99.84 Very High Very High Very High
Morphine 10 99.76 Very High Very High Very High
amygdala 283 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertrophy 6 99.12 Very High Very High Very High
Hyperalgesia 73 98.92 Very High Very High Very High
Stress 25 98.84 Very High Very High Very High
Pain 212 98.72 Very High Very High Very High
Nociception 44 97.68 Very High Very High Very High
Adult Respiratory Distress Syndrome 26 97.48 Very High Very High Very High
Renal Disease 13 96.00 Very High Very High Very High
Cardiovascular Disorder Under Development 20 92.40 High High
Natriuresis 1 89.28 High High
Pressure And Volume Under Development 65 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using patch-clamp recordings of lamina II interneurones in the spinal cord of 15-20-day-old rats, we showed that synaptic inhibition mediated by GABA(A)Rs and its modulation by 3alpha5alphaNS in lamina II of the spinal cord largely depend on activation of PKC.
Regulation (depend) of Positive_regulation (activation) of PKC in lamina associated with kinase c, gaba and spinal cord
1) Confidence 0.62 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17767496 Disease Relevance 0.32 Pain Relevance 1.10
The present result suggests that activation of PKC in the spinal cord contributes to the induction and maintenance of both peripherally-dependent persistent spontaneous pain and contralateral heat hyperalgesia which is dependent upon central sensitization.
Regulation (contributes) of Positive_regulation (activation) of PKC in spinal cord associated with pain, hyperalgesia, kinase c, central sensitization, spontaneous pain and spinal cord
2) Confidence 0.45 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10793237 Disease Relevance 0.58 Pain Relevance 0.83
The whole cell patch-clamp technique was used to examine the effects of protein kinase C (PKC) activation (via the phorbol ester, phorbol 12,13 dibutyrate, PDBu) on the modulation of potassium currents (I(K)) in cultured capsaicin-sensitive neurons isolated from dorsal root ganglia from embryonic rat pups and grown in culture.
Spec (examine) Regulation (effects) of Spec (examine) Positive_regulation (activation) of PKC in neurons associated with kinase c and qutenza
3) Confidence 0.45 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11152736 Disease Relevance 0 Pain Relevance 0.23
We examined the effects of activation of endogenous PKC by 4beta-phorbol 12-myristate 13-acetate (PMA) and dialysis of cells with PKM and a pseudosubstrate inhibitor PKC(19-31) (PKC-I) on kappa- and mu-opioid-mediated inhibition of calcium current, calcium current amplitude, and rundown.
Spec (examined) Regulation (effects) of Spec (examined) Positive_regulation (activation) of PKC associated with opioid
4) Confidence 0.45 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087019 Disease Relevance 0.16 Pain Relevance 0.52
The SERT inhibitor-induced increase in PKC was unaffected by pretreatment with PCPA but was inhibited by calcium.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (increase) of PKC associated with kinase c
5) Confidence 0.45 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.83
The effects of agents that modulate intracellular release of calcium and protein kinase C (PKC) activation on noradrenaline (NA)-induced contractions of epididymal vas deferens in calcium-free/EGTA (1 mM) medium were investigated.
Regulation (modulate) of Positive_regulation (activation) of PKC in vas deferens associated with kinase c and noradrenaline
6) Confidence 0.45 Published 1999 Journal Life Sci. Section Abstract Doc Link 10416820 Disease Relevance 0 Pain Relevance 0.49
To test the hypothesis that activators of protein kinase C (PKC), which is activated following PI hydrolysis, stimulates secretion of beta-endorphins from hypothalamus, we studied the separate effects of stimulators of PKC including phorbol ester 12-myristate-13-acetate (PMA) and 1-oleolyl-2-acetyl glycerol (OAG- a diacyl glycerol analogue) on secretion of immunoreactive (IR-) beta-endorphin (measured by RIA) from dissociated fetal rat hypothalamic cell cultures.
Regulation (effects) of Positive_regulation (stimulators) of PKC in hypothalamus associated with kinase c
7) Confidence 0.44 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1422853 Disease Relevance 0 Pain Relevance 0.27
These findings indicate a functional role for phospholipase C-coupled D1-like receptors in both modulating synaptic transmission in NAcc and potentiating NMDA receptors on a subset of NAcc neurones, via PKC activation.
Regulation (modulating) of Positive_regulation (activation) of PKC in NAcc associated with nucleus accumbens, kinase c and nmda receptor
8) Confidence 0.44 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10218863 Disease Relevance 0.07 Pain Relevance 0.84
However, the current study did not determine the role of PKC activation in the development of the hyperalgesia and future studies should investigate if pre-treatment with PKC inhibitors prevents development of hyperalgesia.
Spec (investigate) Regulation (role) of Positive_regulation (activation) of PKC associated with hyperalgesia and kinase c
9) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.62 Pain Relevance 1.68
Indeed, in animal models of pain there is an increase in phosphorylation of the NR1 subunit and GlurR1 subunit that likely depends on activation of PKC [32-36].
Regulation (depends) of Positive_regulation (activation) of PKC associated with pain and kinase c
10) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.10 Pain Relevance 1.09
The present study was aimed to examine if protein kinase C (PKC) activation is necessarily involved in both the c-fos protein expression in the nocuously-activated c-fos protein-like immunoreactive (Fos-LI) neurons and the concomitant opioid receptor-mediated modulation in the dorsal horn circuitry of the spinal cord.
Regulation (involved) of Spec (examine) Positive_regulation (activation) of PKC in neurons associated with kinase c, dorsal horn, opioid receptor and spinal cord
11) Confidence 0.42 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 15322678 Disease Relevance 0 Pain Relevance 0.51
Although other voltage-gated Na+ currents are modulated by the activation of protein kinase C (PKC), protein kinase A (PKA), or both, the second messenger pathways involved in the modulation of TTX-R INa are still being defined.
Regulation (modulated) of Positive_regulation (activation) of PKC associated with kinase c
12) Confidence 0.41 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852572 Disease Relevance 0.10 Pain Relevance 0.33
A variety of neuromodulator/neurotransmitter receptors, including metabotropic glutamate receptors that are important for pain-related plasticity in the amygdala [12,16], have been shown to couple to ERK activation via PKA and PKC [61].
Regulation (couple) of Positive_regulation (activation) of PKC in amygdala associated with pain, neurotransmitter, glutamate receptor and amygdala
13) Confidence 0.34 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.28 Pain Relevance 0.86
The effects of PKA and PKC activators were blocked by inhibitors of ERK signaling, suggesting that PKA and PKC act as upstream activators of ERK [39,40].
Regulation (effects) of Positive_regulation (activators) of PKC
14) Confidence 0.34 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.54 Pain Relevance 0.90
Pain-related changes in the CeLC include enhanced synaptic transmission and neuronal excitability through a mechanism that is centered on PKA, but not PKC, activation [34].
Regulation (centered) of Positive_regulation (activation) of PKC in neuronal associated with pain, neuronal excitability and amygdala
15) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 1.46 Pain Relevance 1.69
Morphine withdrawal modulates gene expression in the NTS through various second-messenger signal transduction systems including activation of extracellular signal-regulated kinases 1/2 (ERK(1/2)) and protein kinase C (PKC).
Regulation (modulates) of Positive_regulation (activation) of PKC associated with kinase c, withdrawal and morphine
16) Confidence 0.26 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.18 Pain Relevance 0.70
These data are consistent with the hypothesis that BK inhibits whole-cell sustained Ba2+ current in F11-B9 cells via a mechanism that involves activation of PKC.
Regulation (involves) of Positive_regulation (activation) of PKC in F11 associated with kinase c
17) Confidence 0.23 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 2010809 Disease Relevance 0.07 Pain Relevance 0.36
Short-term activation of PKC had no effect on receptor binding or effector enzyme (adenylyl cyclase or PLC-beta) activity.
Neg (no) Regulation (effect) of Positive_regulation (activation) of PKC associated with kinase c
18) Confidence 0.23 Published 2000 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 11003572 Disease Relevance 0.09 Pain Relevance 0.52
Attention should be paid on the maladaptive changes in the vascular wall in which an activated ET-NOX-PKC?
Regulation (changes) of Positive_regulation (activated) of ET-NOX-PKC associated with kinase c
19) Confidence 0.23 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.96 Pain Relevance 0.19
We conclude that lidocaine increases phosphorylation of the tyrosine kinase PP125FAK in the rat hippocampus by a tetrotoxin (TTX)-insensitive mechanism which involves activation of PKC.
Regulation (involves) of Positive_regulation (activation) of PKC in hippocampus associated with kinase c, hippocampus and lidocaine
20) Confidence 0.19 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063155 Disease Relevance 0.14 Pain Relevance 0.60

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox