INT95271

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 46
Total Number 51
Disease Relevance 24.10
Pain Relevance 9.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
CPA 4
neutrophil 3
retinas 2
thoracic 2
neuronal 2
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 7 99.92 Very High Very High Very High
Brush evoked pain 3 99.72 Very High Very High Very High
substance P 31 99.56 Very High Very High Very High
ischemia 273 99.40 Very High Very High Very High
Neuronal nitric oxide synthase 2 99.28 Very High Very High Very High
Spinal nerve ligature 3 99.18 Very High Very High Very High
Pain 20 98.68 Very High Very High Very High
nociceptor 6 98.68 Very High Very High Very High
Spinal cord 14 98.48 Very High Very High Very High
Bioavailability 27 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 145 99.92 Very High Very High Very High
Neuropathic Pain 8 99.72 Very High Very High Very High
Injury 70 99.52 Very High Very High Very High
Diabetes Mellitus 283 99.48 Very High Very High Very High
Cv Unclassified Under Development 277 99.40 Very High Very High Very High
Apoptosis 22 99.08 Very High Very High Very High
Hyperlipidemia 15 98.96 Very High Very High Very High
Hyperglycemia 19 98.58 Very High Very High Very High
Arthritis 23 98.16 Very High Very High Very High
INFLAMMATION 491 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several divalent cations (Mn++, Zn++ and Fe++) suppressed eNOS activity in crude cell extracts and intact cells whereas Cu++ increased eNOS activation [30].
Negative_regulation (suppressed) of eNOS
1) Confidence 0.53 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 0.93 Pain Relevance 0.24
Induction of short time (60 min) Isc, in control rats, produced a loss in the glomerular eNOS and an increase of its interstitial expression (c).
Negative_regulation (loss) of eNOS associated with ischemia
2) Confidence 0.47 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 0.71 Pain Relevance 0.37
The present work extended these studies to include 7-nitroindazole (7-NI), an inhibitor specific for neuronal nitric-oxide synthase (nNOS), N(5)-(-iminoethyl)-L-ornithine (L-NIO), an inhibitor of endothelial NOS (eNOS), and aminoguanidine (AG), a potent inhibitor of inducible NOS (iNOS).
Negative_regulation (inhibitor) of eNOS in neuronal
3) Confidence 0.45 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954818 Disease Relevance 0.22 Pain Relevance 0.37
The present work extended these studies to include 7-nitroindazole (7-NI), an inhibitor specific for neuronal nitric-oxide synthase (nNOS), N(5)-(-iminoethyl)-L-ornithine (L-NIO), an inhibitor of endothelial NOS (eNOS), and aminoguanidine (AG), a potent inhibitor of inducible NOS (iNOS).
Negative_regulation (inhibitor) of endothelial NOS in neuronal
4) Confidence 0.45 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954818 Disease Relevance 0.22 Pain Relevance 0.36
Of note, on 9 day after the last CPA administration, the inhibition of hematopoesis is accompanied with diminished cellular levels of L-arginine, L-citrulline and RNS (4.2; 1.6 and 1.9 times, respectively), and an impairment of the NO synthesis in marrow, associated with the inhibition of both iNOS and cNOS.
Negative_regulation (inhibition) of cNOS in CPA
5) Confidence 0.43 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.07 Pain Relevance 0.04
The fact that the IC50 of L-NNA for the inhibition of eNOS is around 10 times lower than that for iNOS inhibition [24] suggests that, at low doses, L-NNA is inhibiting predominantly the eNOS isoform.
Negative_regulation (inhibition) of eNOS
6) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.60 Pain Relevance 0.23
Animals treated with selective iNOS inhibitors (aminoguanidine, 1400W, L-NIL and AE-ITU) or a selective eNOS inhibitor (L-NIO) present enhanced leukocyte migration to inflammatory sites [25, 27, 40, 41].
Negative_regulation (inhibitor) of eNOS in leukocyte associated with inflammation
7) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.69 Pain Relevance 0.24
The mucosal expression levels of eNOS and iNOS but not nNOS mRNAs were enhanced in arthritic rats compared with normal rats.
Negative_regulation (levels) of eNOS associated with arthritis
8) Confidence 0.41 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19881222 Disease Relevance 1.14 Pain Relevance 0.20
C-reactive protein mRNA in renal cortex was increased in DS-placebo animals (P<0.05 versus DR-placebo) and normalized by celecoxib (P<0.05 versus DS-placebo), whereas eNOS mRNA was decreased in the DS-rofecoxib group (P<0.05 versus DR-placebo, DS-celecoxib, and DS-diclofenac).
Negative_regulation (decreased) of eNOS in renal cortex associated with diclofenac
9) Confidence 0.41 Published 2005 Journal Hypertension Section Abstract Doc Link 15630049 Disease Relevance 0.70 Pain Relevance 0.27
The increased ulcerogenic response in arthritic rats was significantly suppressed by 1400 W (a selective inhibitor of iNOS) and L-iminoethyl ornithine (L-NIO) (a selective inhibitor of eNOS), but not by N(G)-propyl-L-arginine (L-NPA) (a selective inhibitor of nNOS), and almost totally abolished by the co-administration of 1400 W and L-NIO.
Negative_regulation (inhibitor) of eNOS associated with arthritis
10) Confidence 0.37 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19881222 Disease Relevance 1.15 Pain Relevance 0.21
NOS inhibitors alone did not affect the level of nitrate/nitrite, p-nNOS, p-eNOS, or p-ERK1/2 in the LC.
Negative_regulation (inhibitors) of p-eNOS
11) Confidence 0.35 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 20028349 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: In addition to inhibition of PG synthesis, damage induced by metamizol was associated with an inhibition of the NO/cGMP pathway and cNOS activity.
Negative_regulation (inhibition) of cNOS
12) Confidence 0.35 Published 2002 Journal Inflamm. Res. Section Body Doc Link 12234055 Disease Relevance 0 Pain Relevance 0
In contrast, statistically significant increases in both parameters were observed after diclofenac administration. cGMP levels were not influenced with diclofenac treatment, nevertheless metamizol reduced the nucleotide levels, which was accompanied by an inhibition of constitutive NOS (cNOS) activity without modifying the mRNA expression of the enzyme.
Negative_regulation (inhibition) of constitutive NOS
13) Confidence 0.35 Published 2002 Journal Inflamm. Res. Section Body Doc Link 12234055 Disease Relevance 0 Pain Relevance 0
In contrast, statistically significant increases in both parameters were observed after diclofenac administration. cGMP levels were not influenced with diclofenac treatment, nevertheless metamizol reduced the nucleotide levels, which was accompanied by an inhibition of constitutive NOS (cNOS) activity without modifying the mRNA expression of the enzyme.
Negative_regulation (inhibition) of cNOS
14) Confidence 0.35 Published 2002 Journal Inflamm. Res. Section Body Doc Link 12234055 Disease Relevance 0 Pain Relevance 0
So, we could argue that the removal of some divalent cations by EDTA may improve eNOS levels.
Spec (may) Negative_regulation (improve) of eNOS
15) Confidence 0.34 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 0.90 Pain Relevance 0.22
The cNOS enzymatic activity in thoracic spinal tissue was gradually decreased to a minimum at 72 h.
Negative_regulation (decreased) of cNOS in thoracic
16) Confidence 0.33 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11556883 Disease Relevance 0.27 Pain Relevance 1.13
Neuronal nitric oxide synthase (nNOS) mRNA is down-regulated, and constitutive NOS enzymatic activity decreased, in thoracic dorsal root ganglia and spinal cord of the rat by a substance P N-terminal metabolite.
Negative_regulation (decreased) of constitutive NOS in thoracic associated with substance p, spinal cord and neuronal nitric oxide synthase
17) Confidence 0.33 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11556883 Disease Relevance 0.35 Pain Relevance 1.63
The impairment in buccal mucosal ulcer healing by NSAID ingestion is manifested in up-regulation in the expression of ECE-1 responsible for ET-1 generation, suppression in cNOS, and amplification of apoptotic events that delay the healing process.
Negative_regulation (suppression) of cNOS associated with ulcers, cinod and apoptosis
18) Confidence 0.32 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11321515 Disease Relevance 0.84 Pain Relevance 0.36
Deactivation of sensory nerves with capsaicin or inhibition of cNOS by L-NNA significantly attenuated the protective activity of ghrelin and accompanying increase in the GBF.
Negative_regulation (inhibition) of cNOS in sensory nerves associated with qutenza
19) Confidence 0.32 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16581065 Disease Relevance 1.02 Pain Relevance 0.60
The NOS activity was equally distributed between iNOS and cNOS in monocyte, which in the presence of L-arginine and NOS cofactors exerted an elevated activity of iNOS, which prevailed upon the activity of total NOS (determined in the presence of calcium), therefore negative values of cNOS were calculated.
Negative_regulation (values) of cNOS in monocyte
20) Confidence 0.32 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0

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