INT95272

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2008
Negated 3
Speculated 5
Reported most in Body
Documents 19
Total Number 24
Disease Relevance 17.85
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
thoracic aorta 13
kidney medulla 9
plasma 8
kidney cortex 4
retinas 2
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 323 100.00 Very High Very High Very High
Nerve growth factor 59 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
Intracerebroventricular 2 100.00 Very High Very High Very High
cINOD 7 98.62 Very High Very High Very High
Endogenous opioid 2 96.12 Very High Very High Very High
Acupuncture 57 95.68 Very High Very High Very High
Chronic pancreatitis 1 94.00 High High
aspirin 6 81.32 Quite High
Central nervous system 6 81.28 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 2250 100.00 Very High Very High Very High
Ocular Hypertension 75 99.44 Very High Very High Very High
Polycystic Ovary Syndrome 64 98.28 Very High Very High Very High
Ulcers 8 98.28 Very High Very High Very High
Apoptosis 22 98.24 Very High Very High Very High
Pancreatitis 1 94.00 High High
Injury 31 93.00 High High
Hypoxia 3 92.32 High High
Hyperglycemia 120 80.24 Quite High
Glaucoma 18 76.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of diabetes did not produce any change in the expression of preproET-1 in kidney medulla at 14-days and 28-days diabetes groups as compared to control group (Fig 3D).


Regulation (change) of Gene_expression (expression) of preproET-1 in kidney medulla associated with medulla and diabetes mellitus
1) Confidence 0.53 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.33 Pain Relevance 0.11
To explore this idea further, we determined the effect of intracerebroventricular (i.c.v.) administration of anti-beta-endorphin IgG (rabbit) on the expression level of the opioid, corticotropin-releasing hormone and endothelin receptors, and tissue concentration of ET-1.
Spec (determined) Regulation (effect) of Gene_expression (expression) of endothelin associated with opioid and intracerebroventricular
2) Confidence 0.44 Published 2006 Journal Peptides Section Abstract Doc Link 16165252 Disease Relevance 0 Pain Relevance 0.34
Production and effects of endothelin-1 in rat pancreatic stellate cells.
Regulation (effects) of Gene_expression (Production) of endothelin-1 in stellate cells
3) Confidence 0.43 Published 2003 Journal Pancreas Section Title Doc Link 12826908 Disease Relevance 0.09 Pain Relevance 0.09
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Regulation (concentration) of Gene_expression (expression) of preproET-1 in thoracic aorta associated with medulla
4) Confidence 0.39 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.11
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Regulation (concentration) of Gene_expression (expression) of ET-1 in thoracic aorta associated with medulla
5) Confidence 0.39 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.10
Effect of STZ-induced diabetes on the concentration of ET-1 in plasma and expression of preproET-1 in thoracic aorta, kidney cortex and medulla
Regulation (diabetes) of Gene_expression (expression) of preproET-1 in plasma associated with medulla and diabetes mellitus
6) Confidence 0.39 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.36 Pain Relevance 0.09
Effect of STZ-induced diabetes on the concentration of ET-1 in plasma and expression of preproET-1 in thoracic aorta, kidney cortex and medulla
Regulation (diabetes) of Gene_expression (concentration) of ET-1 in plasma associated with medulla and diabetes mellitus
7) Confidence 0.39 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.34 Pain Relevance 0.09
Effect of STZ-induced diabetes on the concentration of ET-1 in plasma and expression of preproET-1 in thoracic aorta, kidney cortex and medulla
Regulation (Effect) of Gene_expression (expression) of preproET-1 in plasma associated with medulla and diabetes mellitus
8) Confidence 0.39 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.37 Pain Relevance 0.09
Effect of STZ-induced diabetes on the concentration of ET-1 in plasma and expression of preproET-1 in thoracic aorta, kidney cortex and medulla
Regulation (medulla) of Gene_expression (expression) of preproET-1 in plasma associated with medulla and diabetes mellitus
9) Confidence 0.39 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.29 Pain Relevance 0.09
A model is proposed assuming there is a feedback loop regulating the production of ET-1 (Fig. 5).
Regulation (regulating) of Gene_expression (production) of ET-1
10) Confidence 0.30 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
To explore this idea further, we determined the effect of intracerebroventricular (i.c.v.) administration of anti-beta-endorphin IgG (rabbit) on the expression level of the opioid, corticotropin-releasing hormone and endothelin receptors, and tissue concentration of ET-1.
Spec (determined) Regulation (effect) of Gene_expression (expression) of ET-1 associated with opioid and intracerebroventricular
11) Confidence 0.29 Published 2006 Journal Peptides Section Abstract Doc Link 16165252 Disease Relevance 0 Pain Relevance 0.34
Therefore, the specific aims of the study are to characterize the progression of STZ-induced renal and vascular dysfunction at 14- and 28-days; and to examine if the progression of STZ-induced diabetes would alter the biosynthesis and activation of ET-1, NO and the phosphorylation of p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and kidney medulla.


Neg (NO) Regulation (alter) of Gene_expression (biosynthesis) of ET-1 in thoracic aorta associated with medulla and diabetes mellitus
12) Confidence 0.23 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.73 Pain Relevance 0.08
To determine the effect of duration of diabetes (14-days to 28-days) on aortic and renal ET-1 biosynthesis we determined the concentration of ET-1 in plasma and expression of ET-1 precursor, preproET-1 in thoracic aorta, kidney cortex and kidney medulla.
Spec (determine) Regulation (effect) of Gene_expression (biosynthesis) of ET-1 in kidney medulla associated with medulla and diabetes mellitus
13) Confidence 0.23 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.23 Pain Relevance 0.10
This was done by analysing endothelin-1 (ET-1), a potent vasoconstrictor involved in ovarian functions, as well as NGF and NGF mRNA expression involved in the pathophysiological process underlying steroid-induced PCO.
Regulation (involved) of Gene_expression (expression) of ET-1 in PCO associated with nerve growth factor and polycystic ovary syndrome
14) Confidence 0.23 Published 2003 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC155675 Disease Relevance 0.66 Pain Relevance 0.66
The impairment in buccal mucosal ulcer healing by NSAID ingestion is manifested in up-regulation in the expression of ECE-1 responsible for ET-1 generation, suppression in cNOS, and amplification of apoptotic events that delay the healing process.
Regulation (responsible) of Gene_expression (generation) of ET-1 associated with ulcers, cinod and apoptosis
15) Confidence 0.21 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11321515 Disease Relevance 0.85 Pain Relevance 0.37
Effect of intravitreal injection of ET-1 and elevated IOP on AQP4 in rat retinas
Regulation (Effect) of Gene_expression (injection) of ET-1 in retinas associated with ocular hypertension
16) Confidence 0.17 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.22 Pain Relevance 0
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Regulation (concentration) of in kidney medulla Gene_expression (expression) of preproET-1 in thoracic aorta associated with medulla
17) Confidence 0.13 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.11
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Regulation (concentration) of in kidney medulla Gene_expression (expression) of ET-1 in thoracic aorta associated with medulla
18) Confidence 0.13 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.10
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Regulation (concentration) of in kidney cortex Gene_expression (expression) of ET-1 in thoracic aorta associated with medulla
19) Confidence 0.13 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.10
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Regulation (concentration) of in kidney cortex Gene_expression (expression) of preproET-1 in thoracic aorta associated with medulla
20) Confidence 0.13 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.11

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