INT95274

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.09
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ece1) peptidase activity (Ece1) extracellular space (Edn1)
extracellular region (Edn1) plasma membrane (Ece1) cell-cell signaling (Edn1)
Edn1 (Rattus norvegicus)
Ece1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 21 99.06 Very High Very High Very High
aspirin 18 81.56 Quite High
Disease Link Frequency Relevance Heat
Ulcers 24 98.40 Very High Very High Very High
Apoptosis 9 98.24 Very High Very High Very High
Injury 6 97.48 Very High Very High Very High
INFLAMMATION 6 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the disturbances in nitric oxide generation and the release of endothelin-1 (ET-1) are the early signs of injury by NSAIDs, we investigated oral mucosal ulcer healing in the presence of NSAID administration by analyzing the expression of endothelin-converting enzyme-1(ECE-1), responsible for ET-1 generation, and the mucosal activity of inducible (NOS-2) and constitutive (cNOS) nitric oxide synthase responsible for nitric oxide production.
Regulation (responsible) of ET-1 Binding (generation) of ECE-1 associated with ulcers, injury and cinod
1) Confidence 0.39 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11321515 Disease Relevance 0.62 Pain Relevance 0.47
As the disturbances in nitric oxide generation and the release of endothelin-1 (ET-1) are the early signs of injury by NSAIDs, we investigated oral mucosal ulcer healing in the presence of NSAID administration by analyzing the expression of endothelin-converting enzyme-1(ECE-1), responsible for ET-1 generation, and the mucosal activity of inducible (NOS-2) and constitutive (cNOS) nitric oxide synthase responsible for nitric oxide production.
Regulation (responsible) of ET-1 Binding (generation) of endothelin-converting enzyme-1 associated with ulcers, injury and cinod
2) Confidence 0.39 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11321515 Disease Relevance 0.62 Pain Relevance 0.47
The impairment in buccal mucosal ulcer healing by NSAID ingestion is manifested in up-regulation in the expression of ECE-1 responsible for ET-1 generation, suppression in cNOS, and amplification of apoptotic events that delay the healing process.
Regulation (responsible) of ET-1 Binding (generation) of ECE-1 associated with ulcers, cinod and apoptosis
3) Confidence 0.39 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11321515 Disease Relevance 0.85 Pain Relevance 0.37

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