INT95286

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.82
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
brain 2
podocyte 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 98.80 Very High Very High Very High
Inflammation 17 98.24 Very High Very High Very High
member 8 1 94.20 High High
Calcium channel 1 91.84 High High
Antinociceptive 2 85.28 High High
Arthritis 2 66.12 Quite High
abdominal pain 2 65.68 Quite High
Crohn's disease 2 56.56 Quite High
Analgesic 2 25.00 Low Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 13 100.00 Very High Very High Very High
INFLAMMATION 6 98.80 Very High Very High Very High
Death 2 96.04 Very High Very High Very High
Encephalitis 1 94.48 High High
Disease 8 90.72 High High
Adhesions 2 87.92 High High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 4 71.68 Quite High
Pressure And Volume Under Development 2 71.32 Quite High
Cancer 3 70.16 Quite High
Necrosis 3 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of ME10092 treatment (1-100 pmol/mouse) on nuclear translocation of NF-kappaB, activation of expression of inflammatory mediators and production of nitric oxide were measured in the lipopolysaccharide (LPS)-induced brain inflammation model in mice in vivo.
Regulation (effect) of Localization (translocation) of NF-kappaB in brain associated with inflammatory mediators, inflammation and encephalitis
1) Confidence 0.60 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.41 Pain Relevance 0.21
TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-kappaB translocation.
Regulation (regulation) of Localization (translocation) of NF-kappaB in podocyte associated with apoptosis
2) Confidence 0.38 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 19546355 Disease Relevance 0.67 Pain Relevance 0.14
C. racemosa extracts did not significantly inhibit iNOS activity and did not affect nuclear translocation of nuclear factor-kappaB (p65 subunit) protein.
Neg (not) Regulation (affect) of Localization (translocation) of nuclear factor-kappaB
3) Confidence 0.26 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703353 Disease Relevance 0 Pain Relevance 0
In this study, we show that down-regulation of VCAM-1 by the chemotherapeutic agent etoposide (VP-16) is associated with altered cellular localization of NF-kappaB.
Regulation (altered) of Localization (localization) of NF-kappaB
4) Confidence 0.17 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.09 Pain Relevance 0
These molecules mediate the regulation of nuclear factor-kappa B (NF-kappa B) activation, cell apoptosis, and interleukin-1 beta secretion through cross-regulated and, sometimes, common signaling pathways.
Regulation (regulation) of Localization (secretion) of nuclear factor-kappa B associated with apoptosis
5) Confidence 0.11 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15059033 Disease Relevance 1.33 Pain Relevance 0.18
These molecules mediate the regulation of nuclear factor-kappa B (NF-kappa B) activation, cell apoptosis, and interleukin-1 beta secretion through cross-regulated and, sometimes, common signaling pathways.
Regulation (regulation) of Localization (secretion) of NF-kappa B associated with apoptosis
6) Confidence 0.11 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15059033 Disease Relevance 1.33 Pain Relevance 0.18

General Comments

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