INT95297

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 7.61
Pain Relevance 8.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
monocytes 1
endothelial cells 1
cerebrospinal fluid 1
astrocytes 1
PBMC 1
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 39 100.00 Very High Very High Very High
Spinal cord 28 99.30 Very High Very High Very High
Eae 2 99.08 Very High Very High Very High
aspirin 4 98.74 Very High Very High Very High
cytokine 52 98.24 Very High Very High Very High
intrathecal 16 97.96 Very High Very High Very High
Sciatic nerve 6 97.64 Very High Very High Very High
Migraine 6 95.28 Very High Very High Very High
Antihyperalgesic 1 93.56 High High
antiallodynic 1 92.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 58 100.00 Very High Very High Very High
Shock 1 99.60 Very High Very High Very High
Cancer 9 99.28 Very High Very High Very High
Injury 4 99.08 Very High Very High Very High
Necrosis 9 98.80 Very High Very High Very High
Colon Cancer 2 98.76 Very High Very High Very High
Nervous System Injury 4 97.92 Very High Very High Very High
Headache 4 95.28 Very High Very High Very High
Epilepsy 2 94.24 High High
Stomach Cancer 3 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of NFkappaB was determined by electrophoretic mobility shift assay (EMSA), and the expression of IkappaBalpha, its inhibitor, in PBMC was analysed by Western blotting.
Spec (analysed) Gene_expression (expression) of IkappaBalpha in PBMC
1) Confidence 0.68 Published 2002 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 12175093 Disease Relevance 0.15 Pain Relevance 0.40
No or low levels of IkappaBalpha mRNA were detected in the lumbar spinal cord of vehicle-injected rats, whereas IkappaBalpha mRNA expression was markedly induced in the spinal cord following intrathecal gp120 in predominantly astrocytes and endothelial cells.
Gene_expression (expression) of IkappaBalpha mRNA in astrocytes associated with intrathecal and spinal cord
2) Confidence 0.64 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.70 Pain Relevance 1.14
Moreover, IkappaBalpha mRNA expression positively correlated with proinflammatory cytokine protein levels in lumbosacral cerebrospinal fluid.
Gene_expression (expression) of IkappaBalpha mRNA in cerebrospinal fluid associated with cytokine
3) Confidence 0.64 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.65 Pain Relevance 1.10
To reveal NF-kappaB activation, we assessed inhibitory factor kappaBalpha (IkappaBalpha) mRNA expression by in situ hybridization, as NF-kappaB activation up-regulates IkappaBalpha gene expression as part of an autoregulatory feedback loop.
Gene_expression (expression) of IkappaBalpha
4) Confidence 0.64 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.93 Pain Relevance 1.27
Concomitantly, IkappaBalpha overproduction prevented the enhanced expression of interleukin-6 and of inducible nitric oxide synthase associated with chronic constriction injury and resulted in prolonged antihyperalgesic and antiallodynic effects.
Gene_expression (overproduction) of IkappaBalpha associated with antihyperalgesic, eae, injury and antiallodynic
5) Confidence 0.54 Published 2007 Journal Mol. Ther. Section Abstract Doc Link 17299402 Disease Relevance 0.94 Pain Relevance 1.15
Histological evaluation, TLR2, TLR4, IRAK3 gene expression, IRAK-3 protein levels, inhibitory kappa B alpha (I?
Gene_expression (expression) of inhibitory kappa B alpha
6) Confidence 0.26 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2841148 Disease Relevance 0.47 Pain Relevance 0.11
No or low levels of IkappaBalpha mRNA were detected in the lumbar spinal cord of vehicle-injected rats, whereas IkappaBalpha mRNA expression was markedly induced in the spinal cord following intrathecal gp120 in predominantly astrocytes and endothelial cells.
Gene_expression (expression) of IkappaBalpha mRNA in endothelial cells associated with intrathecal and spinal cord
7) Confidence 0.22 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.70 Pain Relevance 1.14
To investigate the activation of NF-kappaB, the expression of NF-kappaB in the nuclear and I kappaB alpha in the cytosol extracts were analyzed by Western blot.
Gene_expression (expression) of I kappaB alpha
8) Confidence 0.18 Published 2008 Journal Pharmacology Section Body Doc Link 17785997 Disease Relevance 0.08 Pain Relevance 0
This was accompanied by a transient reduction in IkappaBalpha expression.
Gene_expression (expression) of IkappaBalpha
9) Confidence 0.10 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16919057 Disease Relevance 0.34 Pain Relevance 0.28
This study investigated nuclear factor-kappa B (NF-kappaB) activity by electrophoresis mobility gel shift assay and IkappaBalpha expression by Western blot analysis in monocytes obtained from serial samples of internal jugular venous blood taken from seven migraine patients without aura during attacks.
Gene_expression (expression) of IkappaBalpha in monocytes associated with epilepsy and migraine
10) Confidence 0.10 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16919057 Disease Relevance 0.32 Pain Relevance 0.20
In stable patients the protein expression of IkappaBalpha and heat shock protein72 was reduced by surgical handling (p < 0.04), but was not influenced in unstable patients (immunoblotting).
Gene_expression (expression) of IkappaBalpha associated with shock
11) Confidence 0.08 Published 2007 Journal Basic Res. Cardiol. Section Abstract Doc Link 17268886 Disease Relevance 1.07 Pain Relevance 0.49
Here, we demonstrate that sulindac, sulindac sulfone and indomethacin activate the NF-kappaB pathway in colorectal cancer cells, as determined by western blot analysis of cytoplasmic levels of IkappaBalpha and immunocytochemical analysis of nuclear NF-kappaB/RelA.
Gene_expression (levels) of IkappaBalpha associated with colon cancer
12) Confidence 0.07 Published 2008 Journal Oncogene Section Abstract Doc Link 18059344 Disease Relevance 0.39 Pain Relevance 0.50
In this study, we investigated the early signaling events responsible for modulating NF-kappaB activation using various parameters, such as the expression of pro-inflammatory genes and the phosphorylation levels of inhibitor of kappaB alpha (IkappaB alpha) and its upstream kinases.
Gene_expression (expression) of kappaB alpha associated with inflammation
13) Confidence 0.00 Published 2009 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18775507 Disease Relevance 0.36 Pain Relevance 0.18
Furthermore, unlike aspirin, SC236 affected neither the phosphorylation, degradation, nor expression of IkappaB-alpha, suggesting that the effects of SC236 are independent of IKK activity and IkappaB-alpha gene transcription.
Gene_expression (expression) of IkappaB-alpha associated with aspirin
14) Confidence 0.00 Published 2003 Journal Oncogene Section Abstract Doc Link 12606945 Disease Relevance 0.37 Pain Relevance 0.25
Total levels of the NF-kappaB inhibitor Ikappa-Balpha were reduced during exposure to VP-16.
Gene_expression (levels) of Ikappa-Balpha
15) Confidence 0.00 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.12 Pain Relevance 0.03

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