INT95298

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.62
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
PBMC 2
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 7 92.44 High High
Migraine 3 89.60 High High
Inflammation 1 86.80 High High
cytokine 3 74.08 Quite High
anesthesia 1 68.48 Quite High
qutenza 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Epilepsy 1 90.48 High High
Headache 2 89.60 High High
INFLAMMATION 1 86.80 High High
Endotoxemia 1 82.76 Quite High
Migraine Without Aura 1 75.00 Quite High
Adhesions 2 71.72 Quite High
Sepsis 1 69.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of NFkappaB was determined by electrophoretic mobility shift assay (EMSA), and the expression of IkappaBalpha, its inhibitor, in PBMC was analysed by Western blotting.
Negative_regulation (inhibitor) of Spec (analysed) Gene_expression (expression) of IkappaBalpha in PBMC
1) Confidence 0.38 Published 2002 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 12175093 Disease Relevance 0.15 Pain Relevance 0.40
This was accompanied by a transient reduction in IkappaBalpha expression.
Negative_regulation (reduction) of Gene_expression (expression) of IkappaBalpha
2) Confidence 0.07 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16919057 Disease Relevance 0.34 Pain Relevance 0.28
Total levels of the NF-kappaB inhibitor Ikappa-Balpha were reduced during exposure to VP-16.
Negative_regulation (reduced) of Gene_expression (levels) of Ikappa-Balpha
3) Confidence 0.00 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.12 Pain Relevance 0.03

General Comments

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