INT953

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Context Info
Confidence 0.67
First Reported 1979
Last Reported 2004
Negated 2
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 2.38
Pain Relevance 8.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH) extracellular region (GHRH) cell-cell signaling (GHRH)
Anatomy Link Frequency
plasma 10
spinal 2
follicle 2
urine 2
GHRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 43 99.98 Very High Very High Very High
narcan 43 99.98 Very High Very High Very High
qutenza 10 99.52 Very High Very High Very High
Enkephalin 4 99.40 Very High Very High Very High
opiate 8 99.30 Very High Very High Very High
agonist 13 96.04 Very High Very High Very High
noradrenaline 2 95.96 Very High Very High Very High
spinal stenosis 3 95.68 Very High Very High Very High
Opioid 7 94.56 High High
antagonist 4 92.48 High High
Disease Link Frequency Relevance Heat
Hypertrophy 1 99.96 Very High Very High Very High
Acromegaly 2 99.48 Very High Very High Very High
Obesity 8 98.84 Very High Very High Very High
Hypertension 7 98.84 Very High Very High Very High
Spinal Stenosis 3 95.68 Very High Very High Very High
Body Weight 2 95.56 Very High Very High Very High
Hypoglycemia 4 88.16 High High
Low Back Pain 1 80.40 Quite High
Diuresis 3 76.48 Quite High
Natriuresis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Installation of saline solution containing 10 microM capsaicin produced a significant increase of mean urine output, an increase of GRF, of EPRF and of [Na+] and [K+] urine concentration.
Positive_regulation (increase) of Positive_regulation (increase) of GRF in urine associated with qutenza
1) Confidence 0.67 Published 1995 Journal Scand. J. Urol. Nephrol. Section Abstract Doc Link 7618049 Disease Relevance 0.43 Pain Relevance 0.70
Persistent elevation of growth hormone promotes hypertrophy of the bones and ligaments, resulting in widening of the thoracolumbar vertebral bodies, and developmental narrowing of the spinal canal.
Positive_regulation (promotes) of Positive_regulation (elevation) of growth hormone in spinal associated with hypertrophy
2) Confidence 0.50 Published 1982 Journal J. Neurosurg. Section Abstract Doc Link 7054412 Disease Relevance 0.60 Pain Relevance 0.20
Serum GH levels increased significantly in response to GHRH, clonidine, and moxonidine.
Positive_regulation (increased) of Positive_regulation (increased) of GHRH associated with clonidine
3) Confidence 0.49 Published 1995 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 7584524 Disease Relevance 0 Pain Relevance 0.79
Evidence that alpha 2-adrenergic pathways play a major role in growth hormone (GH) neuroregulation: alpha 2-adrenergic agonism counteracts the inhibitory effect of muscarinic cholinergic receptor blockade on the GH response to GH-releasing hormone, while alpha 2-adrenergic blockade diminishes the potentiating effect of increased cholinergic tone on such stimulation in normal men.
Positive_regulation (role) of Positive_regulation (neuroregulation) of growth hormone
4) Confidence 0.49 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 1677361 Disease Relevance 0 Pain Relevance 0.26
DESIGN: We have studied the insulin response to an oral glucose tolerance test (OGTT) and the GH response to GHRH before and after prolonged treatment with Naltrexone (NTX).
Positive_regulation (response) of Positive_regulation (response) of GHRH
5) Confidence 0.49 Published 1997 Journal Int. J. Obes. Relat. Metab. Disord. Section Body Doc Link 9368834 Disease Relevance 0.10 Pain Relevance 0
Conversely, either beta-adrenergic blockade (PRO), or alpha 2-adrenergic agonism (CLO), or the enhancement of muscarinic cholinergic tone (PD) significantly increased the GH response to GHRH (peaks: 43 +/- 4.6, 55.6 +/- 5.6 and 51.2 +/- 7, micrograms/L; PRO, CLO, and PD, respectively; P < 0.01 vs.
Positive_regulation (increased) of Positive_regulation (response) of GHRH
6) Confidence 0.49 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8094392 Disease Relevance 0 Pain Relevance 0.16
Although all three stimuli induced a marked increase in plasma hGH levels, only clonidine induced a significant increase in plasma GHRH levels.
Positive_regulation (induced) of Positive_regulation (increase) of GHRH in plasma associated with clonidine
7) Confidence 0.48 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2106191 Disease Relevance 0.25 Pain Relevance 0.63
Whereas L-dopa elicited a growth hormone response of similar magnitude in both groups, clonidine infusion induced a significant increase in serum growth hormone in normotensive, but not in hypertensive, subjects. 3.
Neg (not) Positive_regulation (induced) of Positive_regulation (increase) of serum growth hormone associated with hypertension and clonidine
8) Confidence 0.47 Published 1980 Journal Clin. Sci. Section Abstract Doc Link 7357832 Disease Relevance 0.45 Pain Relevance 0.32
Endogenous and exogenous opiate-like compounds have been found to cause increased serum growth hormone and prolactin levels in animals, and, in some cases, humans.
Positive_regulation (cause) of Positive_regulation (increased) of growth hormone associated with opiate
9) Confidence 0.39 Published 1979 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 116298 Disease Relevance 0 Pain Relevance 0.27
This supplementation did not induce a statistically significant increase in serum growth hormone concentrations over a 3 hour period.
Neg (not) Positive_regulation (induce) of Positive_regulation (increase) of serum growth hormone
10) Confidence 0.34 Published 2004 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129157 Disease Relevance 0 Pain Relevance 0
Naloxone increases the response of growth hormone and prolactin to stimuli in obese humans.
Positive_regulation (increases) of Positive_regulation (response) of growth hormone associated with obesity and narcan
11) Confidence 0.32 Published 1987 Journal J. Endocrinol. Invest. Section Title Doc Link 3035002 Disease Relevance 0.43 Pain Relevance 0.52
The intravenous administration of 250 micrograms D-Ala2-MePhe4-Met-enkephalin-O-ol (DAMME) caused a marked increase in circulating growth hormone (GH) and prolactin (PRL), and a fall in cortisol, in 14 normal subjects.
Positive_regulation (increase) of Positive_regulation (increase) of growth hormone associated with enkephalin
12) Confidence 0.27 Published 1986 Journal Horm. Res. Section Abstract Doc Link 2935474 Disease Relevance 0 Pain Relevance 0.40
Naloxone enhances the increase in plasma growth hormone induced by alpha 2-adrenergic stimulation in healthy males.
Positive_regulation (enhances) of Positive_regulation (increase) of plasma growth hormone in plasma associated with narcan
13) Confidence 0.23 Published 1987 Journal Acta Endocrinol. Section Title Doc Link 2881420 Disease Relevance 0 Pain Relevance 0.95
Infusions of larger amounts of purified human growth hormone greatly elevated plasma levels but only led to modest increases in CSF growth hormone.
Positive_regulation (led) of Positive_regulation (increases) of growth hormone in plasma
14) Confidence 0.17 Published 1982 Journal Brain Res. Section Abstract Doc Link 7093687 Disease Relevance 0 Pain Relevance 0.60
Naloxone enhances the increase in plasma growth hormone induced by alpha 2-adrenergic stimulation in healthy males.
Positive_regulation (induced) of Positive_regulation (increase) of plasma growth hormone in plasma associated with narcan
15) Confidence 0.15 Published 1987 Journal Acta Endocrinol. Section Title Doc Link 2881420 Disease Relevance 0 Pain Relevance 0.95
Naloxone enhances the increase in plasma growth hormone induced by alpha 2-adrenergic stimulation in healthy males.
Positive_regulation (increase) of Positive_regulation (induced) of plasma growth hormone in plasma associated with narcan
16) Confidence 0.15 Published 1987 Journal Acta Endocrinol. Section Title Doc Link 2881420 Disease Relevance 0 Pain Relevance 0.95
Exercise-induced changes in several hormones and metabolites were noted, including elevations in circulating lactate, growth hormone (GH), prolactin, cortisol, luteinizing hormone (LH), follicle stimulating hormone (FSH), adrenaline noradrenaline, plasma renin activity (PRA) and aldosterone.
Positive_regulation (elevations) of Positive_regulation (elevations) of growth hormone in follicle associated with noradrenaline
17) Confidence 0.11 Published 1984 Journal Clin. Sci. Section Abstract Doc Link 6383692 Disease Relevance 0 Pain Relevance 0.46

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