INT95312

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.77
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc6a1)
Anatomy Link Frequency
cuneate nucleus 1
spinal trigeminal nucleus 1
Slc6a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
glial activation 1 99.90 Very High Very High Very High
gABA 11 96.64 Very High Very High Very High
Glutamate 2 87.44 High High
Neuropathic pain 4 84.32 Quite High
Dorsal column 1 74.64 Quite High
allodynia 2 63.68 Quite High
GABAergic 2 59.84 Quite High
dysesthesia 1 55.28 Quite High
Paresthesia 1 54.80 Quite High
Pain 4 53.12 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 4 93.84 High High
Neuropathic Pain 6 79.88 Quite High
Nociception 1 59.32 Quite High
Dysesthesia 2 55.28 Quite High
Hyperalgesia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither glial activation nor GAT-1 modulation was detected in the cuneate nucleus.
Neg (Neither) Regulation (modulation) of GAT-1 in cuneate nucleus associated with glial activation
1) Confidence 0.27 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20542084 Disease Relevance 0.77 Pain Relevance 0.91
Dense GAT-1 and GAT-3 but very little GAT-2 immunoreactivity was observed in the normal rat spinal trigeminal nucleus.
Neg (little) Regulation (immunoreactivity) of GAT-1 in spinal trigeminal nucleus
2) Confidence 0.20 Published 2001 Journal Pain Section Abstract Doc Link 11323124 Disease Relevance 0 Pain Relevance 0.05
In rats given three further weekly injections of carrageenan and killed 3 days after the fourth injection, further increases in GAT-1 and GAT-3 immunoreactivities were observed.
Regulation (immunoreactivities) of GAT-1
3) Confidence 0.09 Published 2001 Journal Pain Section Abstract Doc Link 11323124 Disease Relevance 0 Pain Relevance 0.13

General Comments

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