INT95313

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Context Info
Confidence 0.76
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 3.96
Pain Relevance 6.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc6a1)
Anatomy Link Frequency
spinal 1
spinal cord 1
dorsal horn 1
spinal trigeminal nucleus 1
hippocampus 1
Slc6a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 44 100.00 Very High Very High Very High
Dorsal horn 3 99.98 Very High Very High Very High
Hippocampus 10 99.48 Very High Very High Very High
Spinal cord 12 99.20 Very High Very High Very High
Glutamate 21 99.16 Very High Very High Very High
Dopamine 14 99.12 Very High Very High Very High
IPN 2 99.12 Very High Very High Very High
Pain 6 98.40 Very High Very High Very High
Spontaneous pain 4 98.36 Very High Very High Very High
Inflammation 8 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Inflammatory Pain 3 99.12 Very High Very High Very High
Urological Neuroanatomy 2 98.84 Very High Very High Very High
Pain 10 98.40 Very High Very High Very High
INFLAMMATION 5 98.04 Very High Very High Very High
Injury 12 97.52 Very High Very High Very High
Neuropathic Pain 19 95.64 Very High Very High Very High
Hyperalgesia 3 94.08 High High
Convulsion 146 85.12 High High
Glioma 1 83.92 Quite High
Epilepsy 62 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigates the dorsal horn expression of the transporter GAT-1 and its functional involvement towards pain behaviour in the CCI model.
Gene_expression (expression) of GAT-1 in dorsal horn associated with pain, eae and dorsal horn
1) Confidence 0.76 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18694804 Disease Relevance 1.04 Pain Relevance 1.08
Subsequently, spinal protein expression of GAT-1 was assessed by Western blotting.
Gene_expression (expression) of GAT-1 in spinal
2) Confidence 0.76 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18694804 Disease Relevance 1.35 Pain Relevance 1.45
Increased expression of gamma-aminobutyric acid transporters GAT-1 and GAT-3 in the spinal trigeminal nucleus after facial carrageenan injections.
Gene_expression (expression) of GAT-1 in spinal trigeminal nucleus
3) Confidence 0.57 Published 2001 Journal Pain Section Title Doc Link 11323124 Disease Relevance 0 Pain Relevance 0.05
We analyzed the effects of representative volatile and IV general anesthetics on recombinant transporters for norepinephrine (human NET), dopamine (rat DAT), or gamma-aminobutyric acid (rat GAT-1) stably expressed in a porcine kidney cell line (LLC-PK(1)).
Gene_expression (expressed) of GAT-1 in kidney associated with dopamine
4) Confidence 0.54 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12351264 Disease Relevance 0 Pain Relevance 0.27
We investigated the expression of potassium-chloride co-transporter 2 (KCC2) and sodium-potassium-chloride co-transporter 1 (NKCC1) in the rat spinal cord after peripheral inflammation induced by complete Freund's adjuvant (CFA) injection.
Spec (investigated) Gene_expression (expression) of sodium-potassium-chloride co-transporter 1 in spinal cord associated with inflammation and spinal cord
5) Confidence 0.41 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 0.81 Pain Relevance 0.73
TsTX-V did not reduce (3)H-GABA uptake in COS-7 cells expressing the GABA transporters GAT-1 and GAT-3, suggesting that this toxin indirectly reduces the transport.
Gene_expression (expressing) of GAT-1 associated with gaba
6) Confidence 0.24 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17049577 Disease Relevance 0.08 Pain Relevance 0.80
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Gene_expression (production) of GAT-1 in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
7) Confidence 0.05 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.88
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Gene_expression (production) of GAT-1 in hippocampus associated with glutamate, gaba, urological neuroanatomy and hippocampus
8) Confidence 0.02 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.88

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