INT95322

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Context Info
Confidence 0.09
First Reported 2001
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.38
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
paw 1
D2Mit212 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 6 100.00 Very High Very High Very High
Antihyperalgesic 4 99.78 Very High Very High Very High
Analgesic 66 99.76 Very High Very High Very High
tolerance 49 97.92 Very High Very High Very High
Morphine 45 95.48 Very High Very High Very High
Pain 10 95.44 Very High Very High Very High
Cannabinoid 66 94.96 High High
Hyperalgesia 7 94.76 High High
agonist 64 94.44 High High
Neuropathic pain 4 88.16 High High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

9 97.20 Very High Very High Very High
Pain 8 95.44 Very High Very High Very High
Hyperalgesia 9 94.76 High High
Targeted Disruption 3 90.40 High High
Neuropathic Pain 6 83.12 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 75.00 Quite High
Hypothermia 2 60.44 Quite High
Catalepsy 1 59.44 Quite High
Urological Neuroanatomy 10 5.00 Very Low Very Low Very Low
Bordatella Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The analgesic effects of WIN55,212-2 and SAB-378 were blocked by the selective CB(1) antagonist SR141716, but were not affected by the selective CB(2) antagonist SR144528.
Neg (not) Regulation (affected) of WIN55,212-2 associated with antagonist and analgesic
1) Confidence 0.09 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19193902 Disease Relevance 0.89 Pain Relevance 1.79
The antihyperalgesic effect of WIN55,212-2 injected into the ipsilateral paw was blocked by subcutaneously administered SR141716A, but was not affected by intrathecally administered SR141716A.
Neg (not) Regulation (affected) of WIN55,212-2 in paw associated with antihyperalgesic
2) Confidence 0.08 Published 2001 Journal Pain Section Abstract Doc Link 11323130 Disease Relevance 0.69 Pain Relevance 1.08
Nevertheless, the absence of RGS9 did not affect the activity of WIN55,212-2 or its capacity to produce CB1R desensitization.
Neg (not) Regulation (affect) of WIN55,212-2
3) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.28

General Comments

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