INT95328

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 8.59
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Gstp1) protein complex (Gstp1)
Anatomy Link Frequency
livers 1
Mouse 1
fibroblasts 1
lung 1
urine 1
Gstp1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 16 91.92 High High
Paracetamol 8 85.84 High High
Nicotine 12 5.00 Very Low Very Low Very Low
Versed 12 5.00 Very Low Very Low Very Low
positron emission tomography 9 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
drug abuse 6 5.00 Very Low Very Low Very Low
local anesthetic 6 5.00 Very Low Very Low Very Low
lidocaine 6 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 408 99.86 Very High Very High Very High
Carcinoma 15 99.28 Very High Very High Very High
Reprotox - General 1 2 97.64 Very High Very High Very High
Endometrial Cancer 67 97.28 Very High Very High Very High
Bronchogenic Carcinoma 12 96.68 Very High Very High Very High
Benign Prostatic Hypertrophy 1 96.00 Very High Very High Very High
Apoptosis 16 95.16 Very High Very High Very High
Toxicity 20 94.84 High High
Stress 4 94.84 High High
Disease 178 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, in BBs taken from smokers, expression of EPHX1 was significantly lower (p < 0.001), whereas the expression of GSTA2 and GSTP1 were up to triple that in non-smokers.
Gene_expression (expression) of GSTP1 associated with nicotine addiction
1) Confidence 0.61 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.74 Pain Relevance 0
Thus, increased expression of GSTP1 in healthy smokers might protect against accumulation of carcinogens.


Gene_expression (expression) of GSTP1 associated with nicotine addiction
2) Confidence 0.61 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.73 Pain Relevance 0
GSTP1 overexpression inhibited cytotoxic effects of cigarette smoke extract on human fibroblast-derived cells and depletion of GSTP1-induced apoptosis in lung fibroblasts (Ishii et al. 2001, 2003).
Gene_expression (overexpression) of GSTP1 in fibroblasts associated with apoptosis
3) Confidence 0.61 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.97 Pain Relevance 0
In BAL cells of smokers, gene expression of EPHX1 and GSTP1 was significantly higher that that of nonsmokers, whereas expression of the UGT2A1 gene was significantly lower (p < 0.001) (Figure 2).
Gene_expression (expression) of GSTP1 associated with nicotine addiction
4) Confidence 0.61 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.82 Pain Relevance 0
There was no evidence that the absence of GSTP in null animals resulted in enhanced expression of other GST isoforms in the null mice (GST alpha, 1.48%, GST mu, 1.68% of resolved proteins) compared with the wild-type animals (GST alpha, 1.50%, GST mu, 1.40%).
Neg (absence) Gene_expression (absence) of GSTP
5) Confidence 0.58 Published 2003 Journal Proteomics Section Abstract Doc Link 12601812 Disease Relevance 0.29 Pain Relevance 0.20
We have therefore used complementary protein expression profiling techniques to perform a systematic comparison of the protein expression profiles of livers from GSTP null and wild-type mice.
Gene_expression (expression) of GSTP in livers
6) Confidence 0.57 Published 2003 Journal Proteomics Section Abstract Doc Link 12601812 Disease Relevance 0.34 Pain Relevance 0.16
We investigated the gene expression of 19 cytochrome P450 monooxygenases (CYPs) and 3 flavin-containing monooxygenases (FMOs), as well as uridine diphosphate glucuronosyltransferase (UGT) 2A1 (UGT2A1), epoxide hydrolase (EPHX1), glutathione-S-transferase (GST) A2 (GSTA2), GSTP1, and GSTM1 in lung cells obtained from bronchoalveolar lavage (BAL) fluid and in bronchial biopsies (BBs) of smokers (n = 8) and nonsmokers (n = 10).
Spec (investigated) Gene_expression (expression) of GSTP1 in lung associated with nicotine addiction
7) Confidence 0.48 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.68 Pain Relevance 0
Gene expression of CYP1A1, CYP1B1, CYP2S1, GSTP1, and EPHX1 was induced in bronchoalveolar lavage cells of smokers, whereas expression of CYP2B6/7, CYP3A5, and UGT2A1 was repressed.
Gene_expression (expression) of GSTP1 associated with nicotine addiction
8) Confidence 0.48 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1665420 Disease Relevance 0.49 Pain Relevance 0
Promotor methylation of the GSTP1 gene has been detected in the urine and ejaculates of men with prostate cancer but not in patients with benign prostatic hyperplasia (Goessl et al. 2000).
Gene_expression (methylation) of GSTP1 gene in urine associated with benign prostatic hypertrophy and reprotox - general 1
9) Confidence 0.30 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717819 Disease Relevance 1.05 Pain Relevance 0
Mouse lines lacking the P450s CYP1A1, CYP1A2, CYP1B1 and CYP2E1, microsomal epoxide hydrolase (mEH), NADPH:quinone oxidoreductase and the glutathione S-transferase P1 have no deleterious phenotypes, indicating that these enzymes are not required for mammalian development and physiological homeostasis.
Neg (lacking) Gene_expression (lacking) of glutathione S-transferase P1 in Mouse
10) Confidence 0.15 Published 2001 Journal Toxicol. Lett. Section Abstract Doc Link 11323178 Disease Relevance 0.31 Pain Relevance 0.07
42 levels can identify PIB-positive individuals with highest possible sensitivity and specificity, the decreased CSF levels of A?
Gene_expression (identify) of PIB
11) Confidence 0.06 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 0.88 Pain Relevance 0.05
Other genes inactivated by promoter hypermethylation in endometrial cancer include PgR [69], the cell cycle control genes 14-3-3 sigma [70], homeobox gene HOXA11, thrombospondin-2 gene (THBS2) [71], paternally expressed gene 3 (PEG3) [72], as well as the detoxifying enzyme glutathione S-transferase P1 (GSTP1) [73].
Gene_expression (expressed) of glutathione S-transferase P1 associated with endometrial cancer
12) Confidence 0.05 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.29 Pain Relevance 0

General Comments

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