INT95338

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.61
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP1) peptidase activity (CASP1) signal transduction (CASP1)
intracellular (CASP1) cytoplasm (CASP1)
Anatomy Link Frequency
monocytes 2
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 34 99.00 Very High Very High Very High
cINOD 6 96.76 Very High Very High Very High
Inflammation 77 92.76 High High
agonist 48 90.96 High High
Inflammatory stimuli 6 87.28 High High
addiction 14 83.24 Quite High
tolerance 4 74.56 Quite High
anakinra 2 68.72 Quite High
Inflammatory response 9 56.20 Quite High
aspirin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cryopyrin-associated Periodic Syndromes 20 94.72 High High
Syndrome 20 94.00 High High
INFLAMMATION 98 92.76 High High
Disease 46 89.20 High High
Apoptosis 9 86.32 High High
Sepsis 92 83.12 Quite High
Celiac Disease 24 78.16 Quite High
Fever 28 71.92 Quite High
Arthralgia 6 71.48 Quite High
Exanthema 10 70.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect is largely owing to post-translational nitrosation and therefore inactivation of cysteine proteases, such as the interleukin (IL)-1beta converting enzyme (ICE/caspase-1) involved in pro-cytokine processing.
Positive_regulation (owing) of Positive_regulation (inactivation) of ICE associated with cytokine
1) Confidence 0.49 Published 2001 Journal Trends Immunol. Section Abstract Doc Link 11323270 Disease Relevance 0.18 Pain Relevance 0.68
The precise mechanism of P2X7 receptor-induced caspase-1 activation is not clear but is known to require K+ efflux and assembly of the NALP3 inflammasome (11, 12).
Positive_regulation (induced) of Positive_regulation (activation) of caspase-1
2) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.40 Pain Relevance 0.17
We show that human peripheral blood monocytes undergo PS exposure in response to P2X7 receptor activation, which was independent of priming stimulus, caspase-1 activation, and IL-1?
Neg (independent) Positive_regulation (independent) of Positive_regulation (activation) of caspase-1 in monocytes
3) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.09
This results in caspase-1 activation and the subsequent processing of pro-interleukin-1-beta to its active form (Trinchieri & Sher 2007).
Positive_regulation (results) of Positive_regulation (activation) of caspase-1
4) Confidence 0.07 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012437 Disease Relevance 0.60 Pain Relevance 0.03
This, in turn, leads to multimerization of ASC and subsequent recruitment and activation of Caspase-1.
Positive_regulation (leads) of Positive_regulation (activation) of Caspase-1
5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.07 Pain Relevance 0.03
which does not directly require caspase-1 inflammasome activation for its processing [56].
Neg (not) Positive_regulation (require) of Positive_regulation (activation) of caspase-1
6) Confidence 0.05 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.14 Pain Relevance 0.07
, a member of the IL-1 family whose processing does not require caspase-1 activation.
Neg (not) Positive_regulation (require) of Neg (not) Positive_regulation (activation) of caspase-1
7) Confidence 0.03 Published 2009 Journal Purinergic Signal Section Abstract Doc Link PMC2686830 Disease Relevance 0.07 Pain Relevance 0.07
It has been proposed that these mutations result in a gain of function for cryopyrin resulting in increased caspase-1 activation and interleukin-1?
Positive_regulation (increased) of Positive_regulation (activation) of caspase-1
8) Confidence 0.01 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1892774 Disease Relevance 1.58 Pain Relevance 0.14
It has been proposed that these mutations result in a gain of function for cryopyrin resulting in increased caspase-1 activation and interleukin-1?
Positive_regulation (resulting) of Positive_regulation (activation) of caspase-1
9) Confidence 0.01 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1892774 Disease Relevance 1.58 Pain Relevance 0.14

General Comments

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