INT95340

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 1.50
Pain Relevance 7.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIN2A) transport (GRIN2A) plasma membrane (GRIN2A)
Anatomy Link Frequency
oocytes 5
blood 1
lymphocytes 1
embryonic kidney 1
GRIN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 40 99.92 Very High Very High Very High
Glutamate receptor 16 99.48 Very High Very High Very High
ketamine 58 99.10 Very High Very High Very High
analgesia 39 97.08 Very High Very High Very High
Analgesic 61 96.08 Very High Very High Very High
Opioid 58 96.04 Very High Very High Very High
isoflurane 3 96.00 Very High Very High Very High
addiction 12 95.68 Very High Very High Very High
methadone 6 93.84 High High
antagonist 5 92.96 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 12 95.96 Very High Very High Very High
Post Operative Pain 40 93.44 High High
Apoptosis 2 90.88 High High
Pain 84 90.52 High High
Death 2 90.36 High High
Toxicity 7 75.00 Quite High
Increased Venous Pressure Under Development 1 50.96 Quite High
Injury 7 49.60 Quite Low
Hyperalgesia 6 33.36 Quite Low
Neuropathic Pain 10 28.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicated that the mRNA expression of NR2A subunit of NMDA receptors in all three test groups was not statistically different from control subjects.
Gene_expression (expression) of NR2A subunit associated with nmda receptor
1) Confidence 0.77 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20420822 Disease Relevance 0.23 Pain Relevance 1.04
This study was designed to evaluate the possibility of using the mRNA expression state of NR2A and NR3A subunits of NMDA receptors in human peripheral blood lymphocytes as a peripheral marker in opioid addiction studies.
Gene_expression (expression) of NR2A in lymphocytes associated with addiction, nmda receptor and opioid
2) Confidence 0.67 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20420822 Disease Relevance 0.26 Pain Relevance 0.87
Real-time PCR method was used to investigate the mRNA expression level of NR2A and NR3A subunits of NMDA receptors in peripheral blood lymphocytes of all groups.
Spec (investigate) Gene_expression (expression) of NR2A in blood associated with nmda receptor
3) Confidence 0.67 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20420822 Disease Relevance 0.24 Pain Relevance 0.98
IMPLICATIONS: Ketamine and Mg2+ inhibit functioning of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.
Gene_expression (expressed) of NR2A associated with ketamine and glutamate receptor
4) Confidence 0.65 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0 Pain Relevance 0.82
Ketamine and Mg2+ inhibit responses of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.
Gene_expression (expressed) of NR2A associated with ketamine and glutamate receptor
5) Confidence 0.65 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0.05 Pain Relevance 1.10
METHODS: To test this hypothesis, the authors expressed human NR1A/NR2A and NR1A/NR2B NMDA receptors in Xenopus laevis oocytes by injection of messenger RNA prepared in vitro.
Gene_expression (expressed) of NR2A in oocytes
6) Confidence 0.58 Published 2004 Journal Anesthesiology Section Body Doc Link 15166575 Disease Relevance 0.09 Pain Relevance 0
NR1/NR2A or NR1/NR2B receptors were expressed in Xenopus oocytes.
Gene_expression (expressed) of NR2A in oocytes
7) Confidence 0.58 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323344 Disease Relevance 0 Pain Relevance 0.42
Xenopus oocytes, expressing NR1/NR2A or NR1/NR2B glutamate receptors, were studied.
Gene_expression (expressing) of NR2A in oocytes associated with glutamate receptor
8) Confidence 0.58 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0.09 Pain Relevance 0.86
METHODS: alpha1beta2gamma2sgamma-aminobutyric acid type A (GABA(A)), alpha1 glycine, NR1/NR2A N-methyl-d-aspartate, and two pore domain TRESK channels were expressed in Xenopus laevis oocytes and studied using two-electrode voltage clamping.
Gene_expression (expressed) of NR2A in oocytes
9) Confidence 0.58 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17717222 Disease Relevance 0 Pain Relevance 0
Recombinant human NR1/NR2A N-methyl-D-aspartate (NMDA), alpha(1)beta(2)gamma(2S)gamma-aminobutyric acid type A (GABA(A)) or alpha(1) glycine receptors, or GIRK1/GIRK2 channels were expressed in Xenopus laevis oocytes and the effects of GBP (0.1-1000 microM) on them were assessed using a two-electrode, voltage-clamp system.
Gene_expression (expressed) of NR2A in oocytes
10) Confidence 0.58 Published 2007 Journal Acta Anaesthesiol Scand Section Body Doc Link 17073851 Disease Relevance 0 Pain Relevance 0
Human embryonic kidney (HEK293) cells, which do not express native NMDAR, were transfected with NR1/NR2A or NR1/NR2B subunits.
Gene_expression (transfected) of NR2A in embryonic kidney
11) Confidence 0.29 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.26 Pain Relevance 0.31
The loss of membrane integrity induced by heroin was more evident in cells transfected with NR1/NR2B than in cells transfected with NR1 alone or NR1/NR2A.
Gene_expression (transfected) of NR2A
12) Confidence 0.29 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.22 Pain Relevance 0.31
The NMDA receptor is made up of four subunits: two NR1, one NR2A, and one NR2B.
Gene_expression (made) of NR2A associated with nmda receptor
13) Confidence 0.09 Published 2010 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2844689 Disease Relevance 0.05 Pain Relevance 0.67

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