INT95341

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 4.27
Pain Relevance 10.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NDOR1) oxidoreductase activity (NDOR1) cell death (NDOR1)
nucleus (NDOR1) cytoplasm (NDOR1)
Anatomy Link Frequency
embryonic kidney 2
oocytes 2
spinal 1
colon 1
tail 1
NDOR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 43 99.76 Very High Very High Very High
Glutamate receptor 19 99.76 Very High Very High Very High
Dorsal horn 2 99.20 Very High Very High Very High
ketamine 84 99.10 Very High Very High Very High
Glutamate 8 98.84 Very High Very High Very High
nMDA receptor antagonist 6 98.38 Very High Very High Very High
Pain 12 98.28 Very High Very High Very High
analgesia 10 97.08 Very High Very High Very High
Analgesic 24 96.08 Very High Very High Very High
opiate 7 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 2 99.46 Very High Very High Very High
Nervous System Injury 8 99.14 Very High Very High Very High
Pain 10 98.28 Very High Very High Very High
Toxicity 7 97.88 Very High Very High Very High
Colon Cancer 40 97.32 Very High Very High Very High
Neuropathic Pain 16 93.48 High High
Stomach Cancer 2 93.40 High High
Apoptosis 18 90.88 High High
Death 7 90.36 High High
Hyperalgesia 4 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Xenopus oocytes, expressing NR1/NR2A or NR1/NR2B glutamate receptors, were studied.
Gene_expression (expressing) of NR1 in oocytes associated with glutamate receptor
1) Confidence 0.75 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0.09 Pain Relevance 0.87
Xenopus oocytes, expressing NR1/NR2A or NR1/NR2B glutamate receptors, were studied.
Gene_expression (expressing) of NR1 in oocytes associated with glutamate receptor
2) Confidence 0.75 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0.09 Pain Relevance 0.86
Incubation with heroin for 24 h induced a dose-dependent decrease in cell viability both in NR1-transfected and nontransfected cells.
Gene_expression (transfected) of NR1
3) Confidence 0.72 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.24 Pain Relevance 0.31
Expression of NR1/NR2B N-methyl-D-aspartate receptors enhances heroin toxicity in HEK293 cells.
Gene_expression (Expression) of NR1 associated with toxicity and nmda receptor
4) Confidence 0.72 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 17105944 Disease Relevance 0.28 Pain Relevance 0.34
Ketamine and Mg2+ inhibit responses of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.
Gene_expression (expressed) of NR1 associated with ketamine and glutamate receptor
5) Confidence 0.65 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0.05 Pain Relevance 1.10
IMPLICATIONS: Ketamine and Mg2+ inhibit functioning of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.
Gene_expression (expressed) of NR1 associated with ketamine and glutamate receptor
6) Confidence 0.65 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0 Pain Relevance 0.82
IMPLICATIONS: Ketamine and Mg2+ inhibit functioning of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.
Gene_expression (expressed) of NR1 associated with ketamine and glutamate receptor
7) Confidence 0.65 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0 Pain Relevance 0.82
Ketamine and Mg2+ inhibit responses of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.
Gene_expression (expressed) of NR1 associated with ketamine and glutamate receptor
8) Confidence 0.65 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0.05 Pain Relevance 1.10
The loss of membrane integrity induced by heroin was more evident in cells transfected with NR1/NR2B than in cells transfected with NR1 alone or NR1/NR2A.
Gene_expression (transfected) of NR1
9) Confidence 0.63 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.22 Pain Relevance 0.31
Human embryonic kidney (HEK293) cells, which do not express native NMDAR, were transfected with NR1/NR2A or NR1/NR2B subunits.
Gene_expression (transfected) of NR1 in embryonic kidney
10) Confidence 0.62 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.26 Pain Relevance 0.31
The loss of membrane integrity induced by heroin was more evident in cells transfected with NR1/NR2B than in cells transfected with NR1 alone or NR1/NR2A.
Gene_expression (transfected) of NR1
11) Confidence 0.62 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.23 Pain Relevance 0.31
The loss of membrane integrity induced by heroin was more evident in cells transfected with NR1/NR2B than in cells transfected with NR1 alone or NR1/NR2A.
Gene_expression (transfected) of NR1
12) Confidence 0.62 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.22 Pain Relevance 0.31
Human embryonic kidney (HEK293) cells, which do not express native NMDAR, were transfected with NR1/NR2A or NR1/NR2B subunits.
Gene_expression (transfected) of NR1 in embryonic kidney
13) Confidence 0.62 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.26 Pain Relevance 0.32
NMDA receptor antagonist treatment at the time of nerve injury prevents injury-induced changes in spinal NR1 and NR2B subunit expression and increases the sensitivity of residual pain behaviours to subsequently administered NMDA receptor antagonists.
Gene_expression (expression) of NR1 in spinal associated with pain, nmda receptor antagonist, nervous system injury and injury
14) Confidence 0.10 Published 2005 Journal Pain Section Title Doc Link 16150544 Disease Relevance 0.96 Pain Relevance 1.16
Secondly, we used immunoblotting and immunohistochemistry to investigate the effects of nerve injury on NMDA receptor subunit expression, revealing increased expression of NR2B, but not NR2A and reduced NR1 in the superficial dorsal horn.
Gene_expression (expression) of NR1 in dorsal horn associated with nervous system injury, nmda receptor and dorsal horn
15) Confidence 0.10 Published 2005 Journal Pain Section Abstract Doc Link 16150544 Disease Relevance 1.13 Pain Relevance 1.50
Furthermore, overexpression of mini-genes encoding either NR1 or D1 carboxyl tail fragments disrupts the D1-NR1 direct protein-protein interaction and abolishes NMDA-induced changes in both D1 cell surface expression and D1-mediated cAMP accumulation.
Gene_expression (overexpression) of NR1 in tail
16) Confidence 0.04 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0 Pain Relevance 0.49
Isothiocyanates induced protein expression of AKR1C1, NAD(P)H:quinone oxidoreductase 1 (NQO1) and heavy subunit of glutamate-cysteine ligase (GCLC) in a colon cancer cell line [43].
Gene_expression (expression) of oxidoreductase 1 in colon associated with glutamate and colon cancer
17) Confidence 0.01 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.19 Pain Relevance 0.05

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