INT95342

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 4.99
Pain Relevance 9.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIN2B) plasma membrane (GRIN2B)
Anatomy Link Frequency
oocytes 3
embryonic kidney 2
trigeminal ganglion 1
spinal 1
neurons 1
GRIN2B (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 64 100.00 Very High Very High Very High
Glutamate 20 100.00 Very High Very High Very High
Glutamate receptor 16 100.00 Very High Very High Very High
ketamine 59 99.10 Very High Very High Very High
antagonist 9 98.60 Very High Very High Very High
Nerve growth factor 23 98.08 Very High Very High Very High
Hippocampus 16 97.60 Very High Very High Very High
Trigeminal ganglion neurons 2 97.40 Very High Very High Very High
Lasting pain 4 97.28 Very High Very High Very High
analgesia 39 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 100.00 Very High Very High Very High
Cancer 26 99.50 Very High Very High Very High
Toxicity 8 98.08 Very High Very High Very High
Pain 90 96.84 Very High Very High Very High
Low Back Pain 3 95.84 Very High Very High Very High
Nervous System Injury 4 95.68 Very High Very High Very High
Stress Incontinence 5 94.64 High High
Post Operative Pain 40 93.44 High High
Amnesia 5 92.52 High High
Apoptosis 3 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Xenopus oocytes, expressing NR1/NR2A or NR1/NR2B glutamate receptors, were studied.
Gene_expression (expressing) of NR2B in oocytes associated with glutamate receptor
1) Confidence 0.75 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0.09 Pain Relevance 0.87
Expression of NR1/NR2B N-methyl-D-aspartate receptors enhances heroin toxicity in HEK293 cells.
Gene_expression (Expression) of NR2B associated with toxicity and nmda receptor
2) Confidence 0.75 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 17105944 Disease Relevance 0.28 Pain Relevance 0.34
NR1/NR2A or NR1/NR2B receptors were expressed in Xenopus oocytes.
Gene_expression (expressed) of NR2B in oocytes
3) Confidence 0.75 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323344 Disease Relevance 0 Pain Relevance 0.42
The nervous tissues of the tumors exhibit not only strong expression of the NR2B subunits but also reactivity with the patients' antibodies.
Gene_expression (expression) of NR2B in nervous tissues associated with cancer
4) Confidence 0.75 Published 2008 Journal Brain Nerve Section Abstract Doc Link 18807939 Disease Relevance 0.72 Pain Relevance 0.33
It has very high selectivity for NR2B subunits containing NMDA receptors versus the HERG-channel inhibition (therapeutic index=4200 vs NR2B binding IC(50)).
Gene_expression (containing) of NR2B associated with nmda receptor
5) Confidence 0.65 Published 2007 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 17766106 Disease Relevance 0.07 Pain Relevance 0.21
Human embryonic kidney (HEK293) cells, which do not express native NMDAR, were transfected with NR1/NR2A or NR1/NR2B subunits.
Gene_expression (transfected) of NR2B in embryonic kidney
6) Confidence 0.65 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.26 Pain Relevance 0.32
IMPLICATIONS: Ketamine and Mg2+ inhibit functioning of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.
Gene_expression (expressed) of NR2B associated with ketamine and glutamate receptor
7) Confidence 0.65 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0 Pain Relevance 0.82
Ketamine and Mg2+ inhibit responses of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner.
Gene_expression (expressed) of NR2B associated with ketamine and glutamate receptor
8) Confidence 0.65 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323343 Disease Relevance 0.05 Pain Relevance 1.11
METHODS: To test this hypothesis, the authors expressed human NR1A/NR2A and NR1A/NR2B NMDA receptors in Xenopus laevis oocytes by injection of messenger RNA prepared in vitro.
Gene_expression (expressed) of NR2B in oocytes
9) Confidence 0.58 Published 2004 Journal Anesthesiology Section Body Doc Link 15166575 Disease Relevance 0.09 Pain Relevance 0
In an attempt to identify more potent 18-methoxycoronaridine analogs, we have tested a series of 18-methoxycoronaridine congeners by whole-cell patch clamp recording of HEK 293 cells expressing recombinant nicotinic alpha3beta4 receptors or glutamate NR1/NR2B N-methyl-d-aspartate (NMDA) receptors.
Gene_expression (expressing) of NR2B associated with glutamate
10) Confidence 0.58 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178360 Disease Relevance 0 Pain Relevance 0.24
Human embryonic kidney 293 cells were transfected as above with NR2B and postsynaptic density 95 (PSD95, Open Biosystems, Image Consortium cDNA clones, USA) cDNA expression constructs and with the NR1-EGFP tagged expression construct in a ratio of 1:1:1.
Gene_expression (expression) of NR2B in embryonic kidney
11) Confidence 0.46 Published 2010 Journal Brain Section Body Doc Link PMC2877907 Disease Relevance 0 Pain Relevance 0
The most extensively characterized, conantokin-G, is selective for subtypes of NMDA receptors containing the NR2B subunit.
Gene_expression (containing) of NR2B subunit associated with nmda receptor
12) Confidence 0.45 Published 2004 Journal Curr. Med. Chem. Section Abstract Doc Link 15579001 Disease Relevance 0.34 Pain Relevance 0.25
Co-expression of the NR2B subunit of the NMDA receptor with P75 and TrkA NGF receptors by trigeminal ganglion neurons that innervate the masseter muscle was investigated immunohistochemically.
Gene_expression (Co-expression) of NR2B in trigeminal ganglion associated with ganglion cysts, nerve growth factor, nmda receptor and trigeminal ganglion neurons
13) Confidence 0.41 Published 2010 Journal Pain Section Abstract Doc Link 20064691 Disease Relevance 0.23 Pain Relevance 0.88
Approximately 85% of NR2B positive masseter ganglion neurons co-expressed P75 or TrkA receptors, suggesting the potential for interaction.
Gene_expression (expressed) of NR2B in neurons associated with ganglion cysts
14) Confidence 0.36 Published 2010 Journal Pain Section Abstract Doc Link 20064691 Disease Relevance 0.27 Pain Relevance 1.27
The loss of membrane integrity induced by heroin was more evident in cells transfected with NR1/NR2B than in cells transfected with NR1 alone or NR1/NR2A.
Gene_expression (transfected) of NR2B
15) Confidence 0.29 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.23 Pain Relevance 0.31
However, the expression level of the NMDA receptor subunits NR2A and NR2B were massively over-expressed (more than 100%).
Gene_expression (expressed) of NR2B associated with nmda receptor
16) Confidence 0.21 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2518049 Disease Relevance 0.31 Pain Relevance 0.29
However, the expression level of the NMDA receptor subunits NR2A and NR2B were massively over-expressed (more than 100%).
Gene_expression (expression) of NR2B associated with nmda receptor
17) Confidence 0.21 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2518049 Disease Relevance 0.31 Pain Relevance 0.29
Spinal N-methyl-D-aspartate receptor 2B subunit (NR2B)-increased expression plays an important role in the facilitation and maintenance of the persistent pain state due to peripheral nerve injury.
Gene_expression (expression) of Spinal N-methyl-D-aspartate receptor 2B subunit in peripheral nerve associated with pain, nervous system injury, lasting pain, nmda receptor and peripheral nerve injury
18) Confidence 0.19 Published 2007 Journal Gene Ther. Section Abstract Doc Link 17960165 Disease Relevance 0.64 Pain Relevance 0.34
Autoantibodies against the glutamate receptor subunits epsilon2 and delta2 were detected in both the CSF and serum, but these antibodies in the CSF became normal during the clinical course.
Gene_expression (detected) of glutamate receptor subunits epsilon2 associated with glutamate receptor
19) Confidence 0.12 Published 2007 Journal Brain Nerve Section Abstract Doc Link 17533979 Disease Relevance 0.62 Pain Relevance 0.21
To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation and protein expression in the lumbosacral (L6-S2) dorsal horn were studied before and after intracolonic mustard oil (MO) instillation.
Gene_expression (dependent) of NR2B in spinal associated with stress incontinence and dorsal horn
20) Confidence 0.10 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.43 Pain Relevance 0.17

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