INT95347

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIN2B) plasma membrane (GRIN2B)
GRIN2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 99.96 Very High Very High Very High
ketamine 16 97.84 Very High Very High Very High
isoflurane 6 95.96 Very High Very High Very High
nMDA receptor 10 92.48 High High
Analgesic 6 79.04 Quite High
Glutamate 2 46.72 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Volatile anesthetics inhibited NR1/NR2A and NR1/NR2B glutamate receptor function in a reversible, concentration-dependent, voltage-insensitive and noncompetitive manner (half-maximal inhibitory concentration at NR1/NR2A receptors: 1.30 +/- 0.02 minimum alveolar anesthetic concentration [MAC] for isoflurane, 1.18 +/- 0.03 MAC for desflurane, 1.24 +/- 0.06 MAC for sevoflurane; at NR1/NR2B receptors: 1.33 +/- 0.12 MAC for isoflurane, 1.22 +/- 0.08 MAC for desflurane, and 1.28 +/- 0.08 MAC for sevoflurane).
Negative_regulation (inhibited) of NR2B associated with glutamate receptor and isoflurane
1) Confidence 0.57 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323344 Disease Relevance 0 Pain Relevance 0.50
On both NR1/NR2A and NR1/NR2B receptors, 50% inhibitory concentration for volatile anesthetics was reduced approximately 20% by Mg2+, approximately 30% by S(+)-ketamine, and approximately 50% by the compounds in combination.
Negative_regulation (reduced) of NR2B associated with ketamine
2) Confidence 0.18 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323344 Disease Relevance 0 Pain Relevance 0.69

General Comments

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