INT95367

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Context Info
Confidence 0.21
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.50
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 54 100.00 Very High Very High Very High
Inflammatory stimuli 7 100.00 Very High Very High Very High
rheumatoid arthritis 31 96.44 Very High Very High Very High
chemokine 12 94.88 High High
Inflammation 184 94.36 High High
Inflammatory response 25 93.76 High High
cytokine 66 93.04 High High
fibrosis 18 82.64 Quite High
Inflammatory marker 3 70.96 Quite High
antagonist 2 67.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 218 100.00 Very High Very High Very High
Rheumatoid Arthritis 31 96.44 Very High Very High Very High
Infection 19 96.28 Very High Very High Very High
Sepsis 27 94.36 High High
Hemorrhage 2 93.56 High High
Cirrhosis 61 91.28 High High
Cv General 2 Under Development 1 91.20 High High
Mycobacterial Infection 19 88.12 High High
Respiratory Failure 1 87.76 High High
Disease 27 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nitric oxide donor SNAP also blocked iNOS induction while preincubation of atrial fragments with an inhibitor of NOS, L-NAME, prior to morphine or anandamide exposure, restored LPS + IFN-gamma induction of iNOS.
Negative_regulation (restored) of Positive_regulation (induction) of LPS
1) Confidence 0.21 Published 2000 Journal Acta Pharmacol. Sin. Section Body Doc Link 11324436 Disease Relevance 0 Pain Relevance 0
The infusion of rhAPC, however, decreased the LPS-induced elevations of PAP, Pmo and PVRIdwn with intergroup differences (P < 0.05).
Negative_regulation (decreased) of Positive_regulation (elevations) of LPS
2) Confidence 0.17 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.34 Pain Relevance 0.04
HAART treatment (that enable 'partial' immune reconstitution) considerably reduces circulating LPS although total clearance may not be feasible for considerable periods of time.
Negative_regulation (reduces) of Positive_regulation (circulating) of LPS
3) Confidence 0.10 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.09 Pain Relevance 0.21
They specifically inhibit LPS-induced NF-?
Negative_regulation (inhibit) of Positive_regulation (induced) of LPS associated with agonist
4) Confidence 0.05 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.91 Pain Relevance 0.55
In the present study, we further found that melittin and bee venom significantly reduced inflammatory stimuli (LPS and SNP)-induced activation of JNK signal, and the JNK signal specific inhibitor SP600215 suppressed the inhibitory effect of melittin and bee venom on the NF-?
Negative_regulation (reduced) of Positive_regulation (activation) of LPS associated with inflammatory stimuli
5) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.79 Pain Relevance 0.40
In more precise investigation with specific JNK inhibitor SP600215, we further showed that the combination treatment of JNK inhibitor with bee venom and melittin suppressed inhibitory effects of melittin and bee venom on the LPS and SNP-induced NO and PGE2 release with the suppressed effect on the inhibitory effect of melittin and bee venom on the NF-?
Negative_regulation (suppressed) of Positive_regulation (effects) of LPS
6) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.30 Pain Relevance 0.13
These suppressive effects were statistically significant in the inhibitory effect of melittin and Bee venom on the LPS and SNP-induced NF-?
Negative_regulation (effect) of Positive_regulation (induced) of LPS
7) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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