INT95369

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 36
Total Number 37
Disease Relevance 25.09
Pain Relevance 11.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS2) oxidoreductase activity (NOS2) nucleus (NOS2)
intracellular (NOS2) cytoplasm (NOS2)
Anatomy Link Frequency
THP-1 8
cartilage 4
urine 4
plaques 4
smooth muscle cell 4
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 333 100.00 Very High Very High Very High
cytokine 159 99.92 Very High Very High Very High
Inflammatory response 65 99.92 Very High Very High Very High
rheumatoid arthritis 316 99.88 Very High Very High Very High
anesthesia 13 99.78 Very High Very High Very High
epidural 4 99.70 Very High Very High Very High
Pain 62 99.60 Very High Very High Very High
Osteoarthritis 227 98.88 Very High Very High Very High
Morphine 2 98.76 Very High Very High Very High
Abeta 10 98.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 459 100.00 Very High Very High Very High
Rheumatoid Arthritis 316 99.88 Very High Very High Very High
Atherosclerotic Plaque 6 99.62 Very High Very High Very High
Pain 59 99.60 Very High Very High Very High
Diabetes Mellitus 19 99.60 Very High Very High Very High
Hepatocellular Cancer 1 99.40 Very High Very High Very High
Overactive Bladder 12 99.24 Very High Very High Very High
Necrosis 19 99.04 Very High Very High Very High
Osteoarthritis 239 98.88 Very High Very High Very High
Cancer 33 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of BV-2 cells with GLNVA diminished LPS-induced nitric oxide production, overexpression of inducible nitric-oxide synthase (iNOS), and gp91(phox) and intracellular reactive oxygen species (iROS).
Positive_regulation (induced) of Gene_expression (production) of iNOS
1) Confidence 0.55 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.93 Pain Relevance 0.20
Although previous work has provided evidence in rheumatoid arthritis (RA) for increased production of systemic NO [14-21] and increased expression of inducible NO synthase (NOS2) and production of NO [22], most studies of urine and serum NOx levels have been performed in patients eating a normal diet [17] or after only an overnight fast [15].
Positive_regulation (increased) of Gene_expression (expression) of NOS2 in urine associated with rheumatoid arthritis
2) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779437 Disease Relevance 0.63 Pain Relevance 0.24
EAM at 100 mug/ml significantly blocked the LPS induction of iNOS and COX-2 expression, but not COX-1.
Positive_regulation (induction) of Gene_expression (expression) of iNOS
3) Confidence 0.41 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 17597509 Disease Relevance 0.51 Pain Relevance 0.40
A549 cells stimulated with CM showed increases in iNOS mRNA and protein expression, and NO synthesis.
Positive_regulation (increases) of Gene_expression (expression) of iNOS in A549
4) Confidence 0.41 Published 2009 Journal Nitric Oxide Section Abstract Doc Link 18976718 Disease Relevance 0.28 Pain Relevance 0.14
Antagonism of LPS and IFN-gamma induced iNOS expression in human atrial endothelia by morphine, anandamide, and estrogen.
Positive_regulation (induced) of Gene_expression (expression) of iNOS in endothelia associated with morphine
5) Confidence 0.40 Published 2000 Journal Acta Pharmacol. Sin. Section Title Doc Link 11324436 Disease Relevance 0 Pain Relevance 0.19
The expression of mRNA for NOS 2 in J774 macrophages, after 30 min incubation with either lipopolysaccharide or 10(-6) M endomorphin 1 was not upregulated.
Neg (not) Positive_regulation (upregulated) of Gene_expression (expression) of NOS 2 in macrophages
6) Confidence 0.40 Published 2007 Journal Neuroscience Section Abstract Doc Link 17197099 Disease Relevance 0.06 Pain Relevance 0.17
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Positive_regulation (overexpression) of Gene_expression (overexpression) of iNOS
7) Confidence 0.40 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.16
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Positive_regulation (6-OHDA-induced) of Gene_expression (overexpression) of iNOS
8) Confidence 0.40 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.16
Pretreatment of BV-2 cells with GLNVA diminished LPS-induced nitric oxide production, overexpression of inducible nitric-oxide synthase (iNOS), and gp91(phox) and intracellular reactive oxygen species (iROS).
Positive_regulation (overexpression) of Gene_expression (production) of inducible nitric-oxide synthase
9) Confidence 0.40 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.92 Pain Relevance 0.20
-AR stimulation may induce expression of iNOS, which would generate higher levels of NO contributing to the production of inflammatory pain and increased micturition associated with IC.
Spec (may) Positive_regulation (induce) of Gene_expression (expression) of iNOS associated with ipn, overactive bladder and interstitial cystitis
10) Confidence 0.39 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.99 Pain Relevance 0.63
Diabetes is associated with increased myocardial tissue levels of iNOS, O(2)(-), and nitrotyrosine and reduced expression of myocardial angiogenesis factors during ischemia.
Positive_regulation (increased) of Gene_expression (expression) of iNOS associated with diabetes mellitus and ischemia
11) Confidence 0.38 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.14 Pain Relevance 0.30
Diabetes is associated with increased myocardial tissue levels of iNOS, O(2)(-), and nitrotyrosine and reduced expression of myocardial angiogenesis factors during ischemia.
Positive_regulation (increased) of Gene_expression (levels) of iNOS associated with diabetes mellitus and ischemia
12) Confidence 0.38 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.14 Pain Relevance 0.30
CM-induced levels of NO production, iNOS expression and ERK activation were evaluated.
Positive_regulation (induced) of Gene_expression (expression) of iNOS
13) Confidence 0.36 Published 2009 Journal Nitric Oxide Section Abstract Doc Link 18976718 Disease Relevance 0.30 Pain Relevance 0.15
Patients with osteoarthritis (and rheumatoid arthritis) exhibit markers of enhanced NO production in their synovial fluid, serum, and urine, including increased levels of NO, increased circulating nitrites and nitrates, and upregulation of iNOS expression in chondrocytes [24].
Positive_regulation (upregulation) of Gene_expression (expression) of iNOS in synovial fluid associated with rheumatoid arthritis and osteoarthritis
14) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 1.27 Pain Relevance 0.62
Although previous work has provided evidence in rheumatoid arthritis (RA) for increased production of systemic NO [14-21] and increased expression of inducible NO synthase (NOS2) and production of NO [22], most studies of urine and serum NOx levels have been performed in patients eating a normal diet [17] or after only an overnight fast [15].
Positive_regulation (increased) of Gene_expression (expression) of NOS2 in urine associated with rheumatoid arthritis
15) Confidence 0.34 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779437 Disease Relevance 0.64 Pain Relevance 0.25
-AR stimulated, PKA-independent signaling pathway that simultaneously increases the expression of two mediators of inflammation, COX-2 and iNOS.
Positive_regulation (increases) of Gene_expression (expression) of iNOS associated with inflammation
16) Confidence 0.33 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 1.11 Pain Relevance 0.81
Recent studies show that amyloid beta (Abeta), a peptide extensively studied in Alzheimer's disease and that is cleaved from APP by beta- and gamma-secretase, and/or Abeta-like peptides are also present in human atherosclerotic plaques, in particular in activated, inducible nitric oxide synthase (iNOS) expressing perivascular macrophages that had phagocytized platelets.
Positive_regulation (activated) of Gene_expression (expressing) of iNOS in plaques associated with atherosclerotic plaque, alzheimer's dementia, disease and abeta
17) Confidence 0.32 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.99 Pain Relevance 0.38
Recent studies show that amyloid beta (Abeta), a peptide extensively studied in Alzheimer's disease and that is cleaved from APP by beta- and gamma-secretase, and/or Abeta-like peptides are also present in human atherosclerotic plaques, in particular in activated, inducible nitric oxide synthase (iNOS) expressing perivascular macrophages that had phagocytized platelets.
Positive_regulation (inducible) of Gene_expression (expressing) of iNOS in plaques associated with atherosclerotic plaque, alzheimer's dementia, disease and abeta
18) Confidence 0.32 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.99 Pain Relevance 0.38
In these studies, receptor regulated expression of COX-2 and iNOS was dependent upon the intermediary phosphorylation of ERK.
Positive_regulation (dependent) of Gene_expression (expression) of iNOS in intermediary
19) Confidence 0.30 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.32 Pain Relevance 0.19
No subjects were taking anti-cytokine agents such as anti-TNF antibody, a treatment that we have shown decreases the overexpression of blood mononuclear cell NOS2 in RA [25].
Positive_regulation (overexpression) of Gene_expression (overexpression) of NOS2 in mononuclear cell associated with rheumatoid arthritis and cytokine
20) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779437 Disease Relevance 0.99 Pain Relevance 0.53

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