INT95374

Context Info Confidence 0.10 First Reported 1998 Last Reported 1998 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 1.17

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Oprd1 (Mus musculus)

Pain Link Frequency Relevance Heat opioid receptor 8 100.00 MU agonist 4 99.56 agonist 12 98.92

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that long-term administration of both peptide delta opioid receptor agonist (24, 48 h) and non-peptide delta opioid agonist (24 h) significantly decreased mRNA expression of delta opioid receptor and the effect of peptide agonist DPDPE seems to be stronger and last longer than that of non-peptide agonist BW373U86.

Negative_regulation (decreased) of Transcription (expression) of delta opioid receptor associated with mu agonist, agonist and opioid receptor

1) Confidence 0.10 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324539 Disease Relevance 0 Pain Relevance 0.61

[Inhibition of the expression of delta opioid receptor mRNA by long-term exposure of NG-108-15 cell line to delta opioid agonists].

Negative_regulation (Inhibition) of Transcription (expression) of delta opioid receptor associated with mu agonist and opioid receptor

2) Confidence 0.08 Published 1998 Journal Sheng Li Xue Bao Section Title Doc Link 11324539 Disease Relevance 0 Pain Relevance 0.55

General Comments

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