INT95400

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Context Info
Confidence 0.15
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.78
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map3k1) cytoplasm (Map3k1)
Map3k1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 99.86 Very High Very High Very High
Morphine 10 98.06 Very High Very High Very High
agonist 1 94.40 High High
opioid receptor 2 94.08 High High
ischemia 3 85.60 High High
Opioid 6 80.48 Quite High
Ventral tegmentum 1 75.20 Quite High
orphanin 4 75.00 Quite High
Locus ceruleus 1 73.76 Quite High
Catecholamine 2 71.64 Quite High
Disease Link Frequency Relevance Heat
Status Epilepticus 57 88.00 High High
Cv Unclassified Under Development 3 85.60 High High
Neuroblastoma 1 81.68 Quite High
Stress 1 79.00 Quite High
Apoptosis 8 70.76 Quite High
Gliosis 4 69.52 Quite High
INFLAMMATION 12 68.56 Quite High
Pain 2 52.48 Quite High
Convulsion 18 5.00 Very Low Very Low Very Low
Epilepsy 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of ERK was examined with PD 098059, a selective pharmacological antagonist which inhibits the upstream kinase, MEK-1, that phosphorylates and activates ERK.
Negative_regulation (inhibits) of MEK-1 associated with antagonist
1) Confidence 0.15 Published 2001 Journal Basic Res. Cardiol. Section Abstract Doc Link 11327331 Disease Relevance 0.16 Pain Relevance 0.46
The expression of two specific CaM kinases, CaMKIIg and CaMKIIb, was up-regulated (+1.61 and +0.66, respectively), and only calcium/calmodulin-dependent protein kinase kinase 1, alpha (CaMKK1) was down-regulated (?
Negative_regulation (down-regulated) of protein kinase kinase 1
2) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.48 Pain Relevance 0.10
Morphine-induced TH upregulation was blocked upon inclusion of a MEK-1 (mitogen-activated protein kinase kinase-1) inhibitor (PD98059), confirming the role for ERKs in this adaptive response to morphine.
Negative_regulation (inhibitor) of kinase-1 associated with morphine
3) Confidence 0.01 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.13 Pain Relevance 1.36

General Comments

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