INT95405

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Context Info
Confidence 0.08
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.33
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) nucleolus (Trib3)
plasma membrane (Ephb1) nucleus (Trib3) enzyme binding (Trib3)
Anatomy Link Frequency
neurons 2
dorsal horn 2
Trib3 (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 6 99.84 Very High Very High Very High
antagonist 4 99.42 Very High Very High Very High
Sciatic nerve 4 97.88 Very High Very High Very High
Pain 32 95.32 Very High Very High Very High
Eae 4 94.92 High High
Inflammation 73 94.88 High High
Neuropathic pain 9 94.08 High High
agonist 2 93.52 High High
opioid receptor 1 93.20 High High
allodynia 9 93.08 High High
Disease Link Frequency Relevance Heat
Arthralgia 3 95.32 Very High Very High Very High
Injury 7 94.92 High High
INFLAMMATION 71 94.88 High High
Neuropathic Pain 19 94.08 High High
Pain 32 86.40 High High
Cv Unclassified Under Development 1 84.72 Quite High
Spinal Cord Injury 8 81.84 Quite High
Nociception 9 78.88 Quite High
Stress 4 78.12 Quite High
Inflammatory Pain 1 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of ERK was examined with PD 098059, a selective pharmacological antagonist which inhibits the upstream kinase, MEK-1, that phosphorylates and activates ERK.
kinase Positive_regulation (phosphorylates) of Phosphorylation (phosphorylates) of ERK associated with antagonist
1) Confidence 0.08 Published 2001 Journal Basic Res. Cardiol. Section Abstract Doc Link 11327331 Disease Relevance 0.16 Pain Relevance 0.46
Lastly, inter-connections with other signalling pathways in DRG neurons, namely the phosphatidylinositol 3-kinase (PI3K) pathway [118], appear to also conduct to ERK phosphorylation.
kinase Positive_regulation (conduct) of Phosphorylation (phosphorylation) of ERK in neurons
2) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.67 Pain Relevance 0.58
Spinal extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase phosphorylation also peak in dorsal horn astrocytes three weeks after partial sciatic nerve ligation [23].
kinase Positive_regulation (peak) of Phosphorylation (phosphorylation) of ERK in dorsal horn associated with dorsal horn and sciatic nerve
3) Confidence 0.01 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.50 Pain Relevance 0.85

General Comments

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