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Context Info
Confidence 0.08
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) nucleolus (Trib3)
plasma membrane (Ephb1) nucleus (Trib3) enzyme binding (Trib3)
Trib3 (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 99.42 Very High Very High Very High
Pain 24 96.56 Very High Very High Very High
agonist 1 93.52 High High
opioid receptor 1 93.20 High High
Lasting pain 4 92.36 High High
Hyperalgesia 5 87.08 High High
allodynia 7 86.40 High High
ischemia 1 84.72 Quite High
intrathecal 7 82.88 Quite High
Opioid 5 79.60 Quite High
Disease Link Frequency Relevance Heat
Pain 25 96.56 Very High Very High Very High
Hyperalgesia 5 87.08 High High
Neuropathic Pain 16 86.40 High High
Cv Unclassified Under Development 1 84.72 Quite High
INFLAMMATION 16 78.76 Quite High
Stress 2 78.12 Quite High
Nociception 8 75.16 Quite High
Hypersensitivity 3 28.00 Quite Low
Spinal Cord Injury 8 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of ERK was examined with PD 098059, a selective pharmacological antagonist which inhibits the upstream kinase, MEK-1, that phosphorylates and activates ERK.
kinase Positive_regulation (activates) of ERK associated with antagonist
1) Confidence 0.08 Published 2001 Journal Basic Res. Cardiol. Section Abstract Doc Link 11327331 Disease Relevance 0.16 Pain Relevance 0.46
The most commonly used strategy to prevent ERK activation is by blocking the activation of ERK by its upstream kinase MEK (Fig. 4).
kinase Positive_regulation (activation) of ERK
2) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.79 Pain Relevance 0.83

General Comments

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