INT95414

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 40
Total Number 41
Disease Relevance 20.30
Pain Relevance 8.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
brain 7
endothelial cells 3
leukocyte 3
macrophages 1
DA neurons 1
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 19 99.76 Very High Very High Very High
Morphine 81 99.36 Very High Very High Very High
Neuritis 31 99.12 Very High Very High Very High
Inflammation 342 98.92 Very High Very High Very High
antinociception 1 98.80 Very High Very High Very High
IPN 7 98.78 Very High Very High Very High
Central nervous system 486 97.92 Very High Very High Very High
Spinal cord 61 96.00 Very High Very High Very High
metalloproteinase 11 95.96 Very High Very High Very High
opiate 2 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 107 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 14 99.92 Very High Very High Very High
Stress 78 99.90 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 355 99.68 Very High Very High Very High
Infection 195 99.52 Very High Very High Very High
Convulsion 111 99.48 Very High Very High Very High
Multiple Sclerosis 156 99.40 Very High Very High Very High
Optic Neuritis 29 99.12 Very High Very High Very High
Disease 611 99.04 Very High Very High Very High
Epilepsy 136 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The brain uptake clearance (CL(in) ) of ketoprofen across the BBB was 0.0308 +/- 0.0046 mL/min/g whereas the CL(in) of DAKG was 1.60 +/- 0.16 mL/min/g, suggesting a marked increase in BBB permeability following lipidization of ketoprofen.
Positive_regulation (increase) of BBB in brain
1) Confidence 0.41 Published 2000 Journal J Drug Target Section Abstract Doc Link 11328663 Disease Relevance 0.20 Pain Relevance 0.10
One means of overcoming the BBB is with cellular implants that produce and deliver therapeutic molecules directly into the CNS region of interest.
Positive_regulation (overcoming) of BBB
2) Confidence 0.39 Published 2001 Journal Crit Rev Ther Drug Carrier Syst Section Abstract Doc Link 11442201 Disease Relevance 0.14 Pain Relevance 0
We measured the ability of the antisenses to cross the BBB, accumulate in the brain and CSF, decrease levels of Met-Enk in brain and blood, and affect voluntary ethanol drinking.
Positive_regulation (accumulate) of BBB in brain
3) Confidence 0.32 Published 2006 Journal Peptides Section Abstract Doc Link 16229925 Disease Relevance 0 Pain Relevance 0.27
The risk of a drug interaction at the BBB is also increased if one transporter dominates the transport.
Positive_regulation (increased) of BBB
4) Confidence 0.14 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0
The permeability of the BBB to a drug is determined mainly by the drug’s lipophilicity but is also influenced by the presence of active transport processes at the BBB.
Positive_regulation (permeability) of BBB
5) Confidence 0.14 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0
Permeability of the BBB (Rate of Transport)
Positive_regulation (Permeability) of BBB
6) Confidence 0.14 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0
Gf accumulated with delay within CNS lesions yielding a signal intensity peak after 24 h in contrast to Gd-DTPA that immediately passed the disrupted BBB.
Positive_regulation (disrupted) of BBB associated with central nervous system
7) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.50 Pain Relevance 0.32
The disadvantage is that with this method, increased penetration across all membranes, not only the BBB, is increased non-specifically.
Positive_regulation (increased) of BBB
8) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0.03
Consistent with studies using radio-labeled compounds [39], the BBB appeared to be more effective in limiting the entry of Tf into the brain than p97.
Positive_regulation (effective) of BBB in brain
9) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.06 Pain Relevance 0.10
Their experimental results revealed an enhanced BBB permeability [155].
Positive_regulation (enhanced) of BBB
10) Confidence 0.11 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.32 Pain Relevance 0
BBB permeability of drugs can be highly increased by active targeting, a non invasive way to transport drugs to target organs using site-specific ligands.
Positive_regulation (increased) of BBB
11) Confidence 0.11 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.22 Pain Relevance 0.19
This increase in BBB to protein tracers was most pronounced on the second day of morphine withdrawal.
Positive_regulation (increase) of BBB associated with withdrawal and morphine
12) Confidence 0.10 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105918 Disease Relevance 0.57 Pain Relevance 0.77
-cat accelerates BBB maturation.


Positive_regulation (accelerates) of BBB
13) Confidence 0.10 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2575783 Disease Relevance 0 Pain Relevance 0
Volume acquisition of the entire mouse brain was performed pre- and post-gadolinium contrast dye injection using a T1 weighted spin echo sequence (TR200ms, TE10ms, FOV: 4×2.5×2.5 cm, matrix: 256×128×128, NEX 2) to determine the overall volume of gadolinium enhancing areas (areas with increased BBB permeability).


Positive_regulation (increased) of BBB in brain
14) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.18 Pain Relevance 0.09
These observations indicate that inflammatory cell recruitment into the CVOs is not necessarily mediated by the same mechanisms as those regulating leukocyte recruitment across the inflamed BBB, which during EAE was shown to be mainly dependent on ?
Positive_regulation (inflamed) of BBB in leukocyte associated with multiple sclerosis and inflammation
15) Confidence 0.09 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.98 Pain Relevance 0.31
Of note, IFNs and LPS are both able to activate tryptophan catabolism in macrophages [120], a process that may add to the effects of BBB activation during HIV infection.
Positive_regulation (activation) of BBB in macrophages associated with acquired immune deficiency syndrome or hiv infection and infection
16) Confidence 0.09 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.28 Pain Relevance 0.04
Besides, kinins enhance permeability of BBB.
Positive_regulation (enhance) of BBB
17) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.35 Pain Relevance 0.48
Astrocytes apparently control expression of ICAM-1 in endothelial cells of the BBB, and upon exposure to TNF-?
Positive_regulation (endothelial cells) of BBB in endothelial cells
18) Confidence 0.06 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.57 Pain Relevance 0.09
, the migratory activity of uninfected and infected lymphocytes increased in association with an up-regulation of vascular endothelial adhesion molecule (VCAM)-1 and some detectable disturbance of the BBB.
Positive_regulation (increased) of BBB in lymphocytes associated with adhesions
19) Confidence 0.06 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.74 Pain Relevance 0.15
In addition to the inflammation mechanisms described above, recent studies performed in experimental animal models with relevance to human disease show a role for vascular inflammatory mechanisms and leukocyte-endothelial adhesion in the induction of BBB leakage and seizure generation [10,11].
Positive_regulation (induction) of BBB in leukocyte associated with convulsion, inflammation, disease and adhesions
20) Confidence 0.06 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2954970 Disease Relevance 1.40 Pain Relevance 0.31

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