INT95423

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 21.66
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bcl2l1) cytosol (Bcl2l1) mitochondrion (Bcl2l1)
growth (Bcl2l1) cytoskeleton (Bcl2l1) intracellular (Bcl2l1)
Anatomy Link Frequency
Thyroid 1
poly 1
colon 1
cleavage 1
A549 1
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 27 98.26 Very High Very High Very High
Leflunomide 10 97.96 Very High Very High Very High
aspirin 32 97.68 Very High Very High Very High
methadone 12 96.34 Very High Very High Very High
addiction 9 84.76 Quite High
Pain 5 84.40 Quite High
Opioid 4 84.32 Quite High
Inflammation 8 83.84 Quite High
cINOD 18 78.00 Quite High
positron emission tomography 40 77.20 Quite High
Disease Link Frequency Relevance Heat
Cancer 633 100.00 Very High Very High Very High
Apoptosis 298 100.00 Very High Very High Very High
Stress 10 99.86 Very High Very High Very High
Death 49 99.58 Very High Very High Very High
Breast Cancer 56 98.88 Very High Very High Very High
Colon Cancer 25 98.76 Very High Very High Very High
Targeted Disruption 12 98.28 Very High Very High Very High
Thyroid Neoplasm 3 97.50 Very High Very High Very High
Leukemia 21 97.06 Very High Very High Very High
Necrosis 4 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we examined the effects of downregulation of Bcl-2 and Bcl-xL on the chemosensitivity of breast cancer cells in vitro and in vivo with the aim of using this approach as a specific targeting therapy.
Spec (examined) Negative_regulation (downregulation) of Bcl-xL associated with breast cancer
1) Confidence 0.41 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.75 Pain Relevance 0
These results indicate that downregulation of Bcl-xL by AS Bcl-xL enhances drug sensitivity, but not to the same extent as downregulation of Bcl-2.
Negative_regulation (downregulation) of Bcl-xL
2) Confidence 0.40 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0 Pain Relevance 0
The decrease in Bcl-xL was prevented by lactacystin, but not by caspase inhibitors.
Negative_regulation (decrease) of Bcl-xL
3) Confidence 0.40 Published 2005 Journal Kidney Int. Section Body Doc Link 15673306 Disease Relevance 0.08 Pain Relevance 0
RESULTS: While paracetamol did not change the mRNA expression of the antiapoptotic gene bcl-xL, it decreased Bcl-xL protein levels.
Negative_regulation (decreased) of Bcl-xL
4) Confidence 0.40 Published 2005 Journal Kidney Int. Section Body Doc Link 15673306 Disease Relevance 0.09 Pain Relevance 0
Within 4 hours of J0-2 treatment (0.5 microg/g), only 50% of the Reg2-/- mice were alive but with an increased sensitivity to Fas-induced oxidative stress and a decreased level of Bcl-xL.
Negative_regulation (decreased) of Bcl-xL associated with stress
5) Confidence 0.28 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.53 Pain Relevance 0.08
Instead, leflunomide inhibited APAP-induced activation (phosphorylation) of c-jun NH2-terminal protein kinase (JNK), thus preventing downstream Bcl-2 and Bcl-XL inactivation and protecting from mitochondrial permeabilization and cytochrome c release.
Negative_regulation (preventing) of Bcl-XL associated with paracetamol and leflunomide
6) Confidence 0.22 Published 2007 Journal Hepatology Section Abstract Doc Link 17366662 Disease Relevance 0.49 Pain Relevance 1.34
The correlation between lapatinib-induced cell death, Bak activation and Bcl-xL downregulation has been described as well in colon cancer cells [29].
Negative_regulation (downregulation) of Bcl-xL in colon associated with colon cancer and death
7) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.33 Pain Relevance 0.04
Stimulation of apoptosis in lapatinib-treated A549 cells was correlated with increased cleaved PARP, active caspase-3, and proapoptotic Bak-1 levels, and reduction in the antiapoptic IAP-2 and Bcl-xL protein levels.
Negative_regulation (reduction) of Bcl-xL in A549 associated with apoptosis
8) Confidence 0.21 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2883966 Disease Relevance 0.89 Pain Relevance 0
Lapatinib reduced the levels of the two antiapoptotic proteins IAP-2 and Bcl-xL, and increased the levels of the proapoptotic protein Bak-1.
Negative_regulation (reduced) of Bcl-xL
9) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.42 Pain Relevance 0
Therefore, the ability of lapatinib to reduce the levels of Bcl-xL and IAP-2 should increase mitochondria outer membrane permeabilization (MOMP), release cytochrome-C, and induce apoptosis.
Negative_regulation (reduce) of Bcl-xL associated with apoptosis
10) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.28 Pain Relevance 0
In contrast, HIP/PAP transgenic mice were resistant to Fas, with HIP/PAP serving as a sulfhydryl buffer to slow down decreases in glutathione and Bcl-xL.
Negative_regulation (decreases) of Bcl-xL associated with targeted disruption
11) Confidence 0.21 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.51 Pain Relevance 0.08
Justicidin A also reduced Bcl-x(L) and increased Bax and Bak in mitochondria.
Negative_regulation (reduced) of Bcl-x
12) Confidence 0.20 Published 2006 Journal FEBS Lett. Section Abstract Doc Link 16684533 Disease Relevance 0.67 Pain Relevance 0.08
Analysis of EC samples from Transwell revealed an increase in cleavage of caspase 3, concomitant with a decrease in the anti-apoptotic BCl-xL upon TGF-?
Negative_regulation (decrease) of BCl-xL in cleavage associated with apoptosis
13) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.57 Pain Relevance 0
Previous studies from our laboratories have linked the protective abilities of IH636 grape seed proanthocyanidin extract (GSPE) with inactivation of anti-apoptotic gene bcl-XL, and modification of several other critical molecular targets such as DNA-damage/DNA-repair, lipid peroxidation and intracellular Ca2+ homeostasis.
Negative_regulation (inactivation) of bcl-XL associated with apoptosis
14) Confidence 0.12 Published 2001 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11330834 Disease Relevance 0.25 Pain Relevance 0.17
The combination treatment also downregulated the cell-survival proteins including survivin, cyclin D1, Bcl-xL, and upregulated the p53 protein.
Negative_regulation (downregulated) of Bcl-xL
15) Confidence 0.12 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.07 Pain Relevance 0.16
The blockage of EGFR and STAT3-signaling cascades seemingly increased the levels of p53, Bax and decreased levels of Bcl-xL, survivin, and cyclin D1 proteins.
Negative_regulation (decreased) of Bcl-xL
16) Confidence 0.12 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.05 Pain Relevance 0
Methadone inhibited proliferation in leukemia cells and induced cell death through apoptosis induction and activated apoptosis pathways through the activation of caspase-9 and caspase-3, down-regulation of Bcl-x(L) and X chromosome-linked inhibitor of apoptosis, and cleavage of poly(ADP-ribose) polymerase.
Negative_regulation (regulation) of Bcl-x in poly associated with leukemia, methadone, apoptosis and death
17) Confidence 0.11 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18676827 Disease Relevance 1.64 Pain Relevance 0.98
As expected levels of phosphorylated AKT, Bcl-2, Bcl-xL and survivin were significantly reduced in tumors from mice treated with the reg4 antibody compared to control.
Negative_regulation (reduced) of Bcl-xL associated with cancer
18) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 1.06 Pain Relevance 0
Exposure to reg4 antibody resulted in a significant decrease in intra-tumor levels of pAkt, Bcl-xL, Bcl-2, survivin and cyclin D1.


Negative_regulation (decrease) of Bcl-xL associated with cancer
19) Confidence 0.10 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2760775 Disease Relevance 1.01 Pain Relevance 0
Bcl-2 and Bcl-x decreased and P53, Bax, and cytochrome c increased in an iNOS dependent fashion.
Negative_regulation (decreased) of Bcl-x
20) Confidence 0.10 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.75 Pain Relevance 0.07

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