INT95427

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 15.28
Pain Relevance 13.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
neuronal 4
macrophage 3
brain 3
dorsal root ganglion 3
cartilage 2
Mmp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 448 100.00 Very High Very High Very High
dorsal root ganglion 28 99.68 Very High Very High Very High
cytokine 26 99.28 Very High Very High Very High
nMDA receptor 630 99.22 Very High Very High Very High
Osteoarthritis 137 99.16 Very High Very High Very High
Snapping jaw 38 99.08 Very High Very High Very High
Hippocampus 78 98.84 Very High Very High Very High
Inflammation 67 98.44 Very High Very High Very High
Glutamate receptor 30 98.16 Very High Very High Very High
induced neuropathy 4 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 52 100.00 Very High Very High Very High
Hypoxia 18 99.72 Very High Very High Very High
Injury 34 99.60 Very High Very High Very High
Ganglion Cysts 32 99.20 Very High Very High Very High
Osteoarthritis 140 99.16 Very High Very High Very High
Temporomandibular Joint Syndrome 38 99.08 Very High Very High Very High
Middle Cerebral Artery Infarction 15 98.84 Very High Very High Very High
Death 50 98.80 Very High Very High Very High
INFLAMMATION 76 98.44 Very High Very High Very High
Low Back Pain 4 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy.
Positive_regulation (Up-regulation) of matrix metalloproteinase-3 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, induced neuropathy, neuropathic pain and metalloproteinase
1) Confidence 0.70 Published 2008 Journal Cancer Sci. Section Title Doc Link 18754875 Disease Relevance 0.81 Pain Relevance 0.60
By reverse transcription-polymerase chain reaction, the expression levels of MMP-3 and CD163 were markedly up-regulated in paclitaxel-treated dorsal root ganglion.
Positive_regulation (up-regulated) of MMP-3 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.70 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.96 Pain Relevance 0.68
Taken together, the up-regulation of MMP-3 and following macrophage activation caused in the dorsal root ganglion might be a significant event to trigger a series of reactions developing paclitaxel-induced peripheral neuropathic pain.
Positive_regulation (up-regulation) of MMP-3 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and neuropathic pain
3) Confidence 0.61 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.93 Pain Relevance 0.59
Densitometry revealed that the level of the activated MMP-3 was slightly increased upon NMDA treatment (1.54±0.13 fold, mean±SEM; n?
Positive_regulation (activated) of MMP-3
4) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.16
As it was shown, that MMP-3 activation in neuronal tissue during trauma-induced synaptogenesis is dependent on NMDA receptor activity [31], it is conceivable that MMP-3 activation in vivo occurs under conditions of extensive glutamate receptor activation, similar to the conditions of extended stimulation of NMDA receptors in our in vitro experiments.
Positive_regulation (activation) of MMP-3 in neuronal associated with glutamate receptor, nmda receptor and injury
5) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0.39 Pain Relevance 0.20
In control experiments we proved the activation of MMP-3 in the in vitro digestion assays by immunoblotting with an MMP-3-specific antibody, detecting the activated MMP-3 protein (44/45 kDa) (Fig. 3B).
Positive_regulation (activated) of MMP-3 protein
6) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.21
In control experiments we proved the activation of MMP-3 in the in vitro digestion assays by immunoblotting with an MMP-3-specific antibody, detecting the activated MMP-3 protein (44/45 kDa) (Fig. 3B).
Positive_regulation (activation) of MMP-3
7) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.21
These findings suggest that MMP-3 activation is a hallmark of early degenerative changes in ID.
Positive_regulation (activation) of MMP-3
8) Confidence 0.57 Published 2009 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 19117728 Disease Relevance 0.40 Pain Relevance 0.45
This increase in the active form of MMP-3 was also confirmed by Western blotting.
Positive_regulation (increase) of MMP-3
9) Confidence 0.57 Published 2009 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 19117728 Disease Relevance 0.42 Pain Relevance 0.49
It was found that MMP-3 activity was transiently increased in the intermediate stage.
Positive_regulation (increased) of MMP-3
10) Confidence 0.57 Published 2009 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 19117728 Disease Relevance 0.41 Pain Relevance 0.49
IL-1alpha significantly induced an increase of active MMP9 as well as pro- and active MMP3, but had no effect on the MMP2 activity in both types of cells.
Positive_regulation (increase) of MMP3
11) Confidence 0.53 Published 2001 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11330935 Disease Relevance 0.25 Pain Relevance 0.60
In order to analyse whether MMP-3 might be a candidate protease for to cleave the NMDA receptor NR1 subunit, we performed in vitro MMP-3 digestion assays with activated MMP-3 and solubilized membrane proteins from rat brain.
Positive_regulation (activated) of MMP-3 in brain associated with nmda receptor
12) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.19
As shown in Figure 3A, activated MMP-3 degraded solubilized NR1 subunits of about 110–120 kDa.
Positive_regulation (activated) of MMP-3
13) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.16
Our laboratory has focused on hippocampal mediated spatial memory and measured elevations in hippocampal MMP-3 and MMP-9 during acquisition of the Morris water
Positive_regulation (elevations) of MMP-3 associated with metalloproteinase
14) Confidence 0.48 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838960 Disease Relevance 0.24 Pain Relevance 0.63
After incubation of recombinant S1S2M protein with active MMP-3, we detected cleavage products of ?
Positive_regulation (incubation) of MMP-3 in cleavage
15) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.11
Importantly, it was demonstrated that the released and proteolytically activated MMP-3 acts as signaling molecule to activate microglia, which in turn might play a role in exacerbating degenerative human brain disorders, such as Parkinson's disease [32].
Positive_regulation (activated) of MMP-3 in brain associated with brain disease and disease
16) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0.51 Pain Relevance 0.17
This MMP-3 up-regulation occurred prior to macrophage accumulation in the dorsal root ganglion.
Positive_regulation (up-regulation) of MMP-3 in macrophage associated with ganglion cysts and dorsal root ganglion
17) Confidence 0.41 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.93 Pain Relevance 0.67
MMP3 and MMP9 mRNAs were also inducible in these cells by IL-1alpha stimulation.
Positive_regulation (inducible) of MMP3
18) Confidence 0.41 Published 2001 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11330935 Disease Relevance 0.24 Pain Relevance 0.60
MMP-3 (100 ng, Chemicon, Temecula, USA) was activated with 1.5–5 mM 4-aminophenyl-mercuricacetat (APMA) for 2 hr at 37°C and subsequently incubated with 50 µg of resuspended membrane proteins in a final volume of 20 µl for 15 hr at 37°C.
Positive_regulation (activated) of MMP-3
19) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0
Indeed, more recently it was shown that activated MMP-3 is released from apoptotic neuronal cells.
Positive_regulation (activated) of MMP-3 in neuronal associated with apoptosis
20) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0.49 Pain Relevance 0.18

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