INT95457

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Context Info
Confidence 0.63
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.29
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Nka1 (Rattus norvegicus)
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 18 99.90 Very High Very High Very High
addiction 2 98.04 Very High Very High Very High
Neurotransmitter 2 97.68 Very High Very High Very High
nociceptor 4 96.84 Very High Very High Very High
antagonist 2 95.68 Very High Very High Very High
Dorsal horn neuron 2 89.36 High High
Spinal cord 6 88.24 High High
Inflammation 2 85.40 High High
Disease Link Frequency Relevance Heat
Nociception 2 91.00 High High
INFLAMMATION 2 85.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that SP and NKA induce NK-1 receptor internalization with identical dose dependence and induce increases in intracellular calcium at the same concentrations, suggesting that SP and NKA equally activate the NK-1 receptor.
NKA Positive_regulation (activate) of NK-1 receptor associated with addiction and substance p
1) Confidence 0.63 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11331395 Disease Relevance 0.15 Pain Relevance 0.69
We conclude that NKA not only targets the NK-1 receptor but may be a predominant pronociceptive primary afferent neurotransmitter.
NKA Positive_regulation (targets) of NK-1 receptor associated with neurotransmitter
2) Confidence 0.49 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11331395 Disease Relevance 0.14 Pain Relevance 0.61

General Comments

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