INT9546

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Context Info
Confidence 0.03
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0
Pain Relevance 5.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) extracellular region (Penk) mRNA processing (Adarb1)
nucleolus (Adarb1) RNA binding (Adarb1) nucleus (Adarb1)
Anatomy Link Frequency
brain 1
Adarb1 (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 45 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Delta opioid receptors 3 100.00 Very High Very High Very High
antagonist 4 98.94 Very High Very High Very High
Opioid 6 96.60 Very High Very High Very High
narcan 3 95.92 Very High Very High Very High
Dynorphin 1 94.88 High High
agonist 3 94.48 High High
Kappa opioid receptor 1 94.16 High High
mu opioid receptor 1 86.56 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the fact that the two enkephalin-induced effects were more effectively antagonized by naloxone, a relatively selective mu-opioid antagonist, than by naltrindole, a specific delta-antagonist, or by nor-binaltorphimine, a specific kappa-antagonist, showed that these two effects were produced by the interaction of enkephalin with mu receptors.
receptors Binding (interaction) of enkephalin associated with antagonist, narcan, enkephalin and opioid
1) Confidence 0.03 Published 1992 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1424102 Disease Relevance 0 Pain Relevance 1.16
When rat brain membranes were incubated with [D-Ala2,Leu(CH2SNpys)5]enkephalin, and assayed for the inhibition of binding of DAGO and DSLET enkephalin analogs to opioid receptors, the number of receptors decreased sharply, depending upon the concentration of this SNpys-containing enkephalin.
receptors Binding (binding) of enkephalin in brain associated with opioid receptor and enkephalin
2) Confidence 0.01 Published 1996 Journal J. Biochem. Section Abstract Doc Link 8889834 Disease Relevance 0 Pain Relevance 0.79
Both Leu- and Met-enkephalin showed only a 3-fold higher apparent affinity (EC50: 30 nM) for presynaptic delta-opioid receptors, mediating inhibition of striatal [14C]acetylcholine release, than for presynaptic mu receptors.
receptors Binding (affinity) of Met-enkephalin associated with delta opioid receptors and enkephalin
3) Confidence 0.01 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8229747 Disease Relevance 0 Pain Relevance 1.11
Preincubation of rat cortical membranes with an IgG fraction isolated from antiserum OC2 was able to produce a marked reduction in the ability of the synthetic enkephalin [D-Ala2,D-Leu5] enkephalin (DADLE) (which interacts with delta and mu but not significantly with kappa receptors) to displace specific binding of [3H] diprenorphine (which binds to all of these sites), demonstrating a clear interaction of the mu and delta receptors with one or more variants of Go.
receptors Binding (interacts) of enkephalin associated with enkephalin
4) Confidence 0.01 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8393523 Disease Relevance 0 Pain Relevance 0.39
SUPERFIT, a delta-selective irreversible ligand, decreased [(3)H][d-Ala(2),d-Leu(5)]enkephalin binding to delta receptors by approximately 75% and to mu receptors by approximately 50% in dimer cells.
receptors Binding (binding) of enkephalin associated with enkephalin
5) Confidence 0.00 Published 2008 Journal Peptides Section Abstract Doc Link 18472184 Disease Relevance 0 Pain Relevance 0.79
SUPERFIT, a delta-selective irreversible ligand, decreased [(3)H][d-Ala(2),d-Leu(5)]enkephalin binding to delta receptors by approximately 75% and to mu receptors by approximately 50% in dimer cells.
receptors Binding (binding) of enkephalin associated with enkephalin
6) Confidence 0.00 Published 2008 Journal Peptides Section Abstract Doc Link 18472184 Disease Relevance 0 Pain Relevance 0.87

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