INT95461

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
prefrontal 2
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 19 100.00 Very High Very High Very High
Kinase C 7 99.98 Very High Very High Very High
fortral 5 96.40 Very High Very High Very High
conotoxin 2 94.88 High High
Calcium channel 6 94.24 High High
Nucleus accumbens 1 87.84 High High
tetrodotoxin 3 87.32 High High
Nicotine 7 77.36 Quite High
sodium channel 1 76.24 Quite High
antagonist 2 57.40 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these data suggest that activation of sigma(2)-receptors results in the regulation of DAT activity via a calcium- and protein kinase C-dependent signaling mechanism.
Positive_regulation (results) of Regulation (regulation) of DAT associated with kinase c
1) Confidence 0.47 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11907188 Disease Relevance 0 Pain Relevance 0.74
Activity-dependent regulation of the dopamine transporter is mediated by Ca(2+)/calmodulin-dependent protein kinase signaling.
Positive_regulation (mediated) of Regulation (regulation) of dopamine transporter associated with dopamine
2) Confidence 0.40 Published 2008 Journal Eur. J. Neurosci. Section Title Doc Link 19046383 Disease Relevance 0 Pain Relevance 0.52
Protein kinase C regulation of dopamine transporter initiated by nicotinic receptor activation in slices of rat prefrontal cortex.
Positive_regulation (initiated) of Regulation (regulation) of dopamine transporter in prefrontal associated with dopamine and kinase c
3) Confidence 0.32 Published 2001 Journal J. Neurochem. Section Title Doc Link 11331413 Disease Relevance 0 Pain Relevance 0.70

General Comments

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