INT95466

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2007
Negated 4
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 3.66
Pain Relevance 6.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
neuronal 3
dendrites 1
sensory neurons 1
P19 1
pyramidal neurons 1
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 318 100.00 Very High Very High Very High
antagonist 217 100.00 Very High Very High Very High
Pyramidal cell 16 98.50 Very High Very High Very High
Glutamate receptor 17 96.68 Very High Very High Very High
Pain 95 96.24 Very High Very High Very High
tetrodotoxin 26 96.24 Very High Very High Very High
Glutamate 134 95.84 Very High Very High Very High
sodium channel 24 95.24 Very High Very High Very High
noradrenaline 57 94.80 High High
qutenza 57 94.44 High High
Disease Link Frequency Relevance Heat
Nociception 83 99.44 Very High Very High Very High
Embryonal Carcinoma 7 97.76 Very High Very High Very High
Pain 105 96.24 Very High Very High Very High
Hyperalgesia 21 93.68 High High
Nervous System Injury 7 93.44 High High
Neuropathic Pain 31 92.92 High High
Anaplastic Astrocytoma 4 90.76 High High
INFLAMMATION 51 88.96 High High
Ganglion Cysts 417 88.56 High High
Bordatella Infection 147 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Northern blots revealed an age-related increase in levels of mRNA for P2Y6 receptors in cultures obtained at postnatal days 1 and 5, respectively, but no change in transcripts for P2Y1 and P2Y2.
Neg (no) Regulation (change) of P2Y2
1) Confidence 0.56 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11331416 Disease Relevance 0 Pain Relevance 0.28
A following study from the same group revealed the importance of P2Y2 receptors in nociception through TRPV1 [24].
Regulation (importance) of P2Y2 associated with nociception
2) Confidence 0.33 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.56 Pain Relevance 0.74
It efficiently inhibits P2X receptors, but it discriminates between ADP and UTP responses on P2Y receptors.
Regulation (responses) of P2Y
3) Confidence 0.32 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.09 Pain Relevance 0.11
Whether these presynaptic P2Y receptors affected transmitter release through a modulation of Ca2+ or K+ channels remained unfortunately unknown.
Spec (Whether) Regulation (affected) of P2Y
4) Confidence 0.30 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.23
The effects of P2Y receptor activation on neuronal ion channels that have been observed most consistently and frequently are (1) inhibition of voltage-activated Ca2+ currents, (2) activation of Ca2+-dependent K+ channels or GIRKs, and (3) inhibition of IM.
Regulation (effects) of P2Y receptor in neuronal
5) Confidence 0.30 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.13 Pain Relevance 0.21
P2 purinoceptor antagonists [suramin (100 microM) and reactive blue-2 (RB-2, 50 microM)] or small conductance Ca(2+)-activated K(+) channel blocker, apamin (0.5 microM), significantly decreased the relaxation to 54.4% and 25.6% or 19.4% of the control (P<0.01), respectively, whereas selective P2Y(1) purinoceptor antagonist MRS2179 (10 microM) failed to affect the relaxation.
Neg (failed) Regulation (affect) of P2Y associated with antagonist
6) Confidence 0.30 Published 2003 Journal Auton Neurosci Section Abstract Doc Link 12559198 Disease Relevance 0 Pain Relevance 0.21
Our results highlighting a role for P2Y1 and P2Y2 receptors in shortterm calcium signalling are consistent with data from Gallagher and Salter [38], showing that these receptors are both necessary for propagation of calcium waves in rat spinal cord astrocytes and in human 1321N1 astrocytoma cells.
Regulation (role) of P2Y2 in astrocytes associated with anaplastic astrocytoma and spinal cord
7) Confidence 0.27 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.09 Pain Relevance 0.26
In addition to the pyrimidine nucleotides acting on P2Y2, P2Y4, and P2Y6 receptors, the ADP analog ADP-?
Regulation (acting) of P2Y2
8) Confidence 0.20 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.69 Pain Relevance 0.62
The investigation of different P2Y receptor agonists acting selectively on the P2Y1 or P2Y2/4 subtypes showed that these receptors can both stimulate and inhibit the excitability of sensory neurons without significant subtype specificity.
Regulation (acting) of P2Y receptor in sensory neurons associated with agonist
9) Confidence 0.20 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.78 Pain Relevance 0.76
A number of studies have addressed the capabilities of nucleotides to mobilise Ca2 and to induce the opening of store-operated Ca2+ channels by acting on microglial P2Y receptors [21, 22].
Regulation (acting) of P2Y
10) Confidence 0.19 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.49 Pain Relevance 0.22
Hence, the regulation of Ca2+ channels and Ca2+-dependent K+ channels via P2Y receptors will preferentially lead to changes in synaptic transmission via a presynaptic modulation of transmitter release, whereas the control of GIRKs and KCNQ channels will rather cause changes in the postsynaptic excitability.
Regulation (regulation) of P2Y
11) Confidence 0.18 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.12
Unfortunately, most of our current knowledge concerning the regulation of neuronal Ca2+ channels via P2Y and other G protein-coupled receptors stems from whole-cell experiments only.


Regulation (regulation) of P2Y in stems
12) Confidence 0.18 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.06 Pain Relevance 0
Regulation of ligand-gated ion channels by P2Y receptors
Regulation (Regulation) of P2Y
13) Confidence 0.18 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.05 Pain Relevance 0.21
In layer V pyramidal neurons of the rat prefrontal cortex, adenine and uridine nucleotides, presumably acting on P2Y2 receptors, were found to enhance currents elicited by N-methlyl-d-aspartate (NMDA) [122].
Regulation (acting) of P2Y2 in pyramidal neurons associated with pyramidal cell
14) Confidence 0.18 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.29
Regulation of Ca2+ channels via P2Y receptors
Regulation (Regulation) of P2Y
15) Confidence 0.18 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.15 Pain Relevance 0.50
Regulation of neuronal ion channels via P2Y receptors

Within the last 15 years, at least 8 different G protein-coupled P2Y receptors have been characterized.

Regulation (Regulation) of P2Y in neuronal
16) Confidence 0.18 Published 2004 Journal Purinergic Signal Section Title Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0
For instance, the triphosphate sensitivity of P2Y2 and 4 receptors can only be demonstrated unequivocally, if the conversion of nucleoside diphosphates to triphosphates is prevented [20].
Regulation (sensitivity) of P2Y2
17) Confidence 0.18 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.22
Regulation of Na+ channels via P2Y receptors
Regulation (Regulation) of P2Y
18) Confidence 0.18 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.09 Pain Relevance 0.46
This review summarizes the current knowledge about the modulation of such neuronal ion channels via P2Y receptors.
Regulation (modulation) of P2Y in neuronal
19) Confidence 0.18 Published 2004 Journal Purinergic Signal Section Abstract Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0
Regulation of K+ channels by P2Y receptors
Regulation (Regulation) of P2Y
20) Confidence 0.18 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.05 Pain Relevance 0

General Comments

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