INT95467

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.43
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
sensory neurons 1
hippocampus 1
microglia 1
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 20 98.76 Very High Very High Very High
Neuropathic pain 8 98.00 Very High Very High Very High
nociceptor 2 97.88 Very High Very High Very High
Hippocampus 37 97.60 Very High Very High Very High
unmyelinated 1 97.40 Very High Very High Very High
noradrenaline 27 94.80 High High
Lasting pain 2 94.24 High High
Neurotransmitter 62 91.36 High High
medulla 12 89.12 High High
Kinase C inhibitor 3 88.16 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 17 98.12 Very High Very High Very High
Neuropathic Pain 20 98.00 Very High Very High Very High
Nervous System Injury 8 97.52 Very High Very High Very High
Pain 6 94.24 High High
Neurodegenerative Disease 15 78.20 Quite High
Nociception 3 74.88 Quite High
Death 9 59.40 Quite High
Hypersensitivity 1 56.88 Quite High
Syndrome 1 51.20 Quite High
Apoptosis 4 40.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Northern blots revealed an age-related increase in levels of mRNA for P2Y6 receptors in cultures obtained at postnatal days 1 and 5, respectively, but no change in transcripts for P2Y1 and P2Y2.
Transcription (transcripts) of P2Y2
1) Confidence 0.49 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11331416 Disease Relevance 0 Pain Relevance 0.28
In situ hybridization analysis revealed widespread expression of P2Y2 mRNA in sensory neurons.
Transcription (expression) of P2Y2 in sensory neurons
2) Confidence 0.45 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12453048 Disease Relevance 0.07 Pain Relevance 0.26
High mRNA expression was detected for P2Y2, P2Y6, P2Y12 and P2Y14.
Transcription (expression) of P2Y2
3) Confidence 0.38 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.07
High mRNA expression was detected for P2Y2, P2Y6, P2Y12 and P2Y14.
Transcription (detected) of P2Y2
4) Confidence 0.38 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.07
Structure, pharmacology, and signal transduction of P2Y receptors
Transcription (transduction) of P2Y
5) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.18 Pain Relevance 0.11
Here, we show that the level of P2Y(12)R mRNA expression was markedly increased in the spinal cord ipsilateral to the nerve injury and that this expression was highly restricted to ionized binding calcium adapter molecule 1-positive microglia.
Transcription (expression) of P2Y in microglia associated with nervous system injury and spinal cord
6) Confidence 0.24 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463248 Disease Relevance 0.98 Pain Relevance 0.72
There was a marked decrease in the concentration of mRNA coding for P2Y1 receptors and upregulation of mRNA transcription coding for P2Y2 receptors in freshly isolated astrocytes of developing rat hippocampus [57].


Transcription (transcription) of P2Y2 in hippocampus associated with hippocampus
7) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.19 Pain Relevance 0.09
For detailed information on the distribution of individual P2Y receptor mRNAs and proteins, we refer to recent reviews on this particular topic [85, 101].


Transcription (distribution) of P2Y
8) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox