INT9547

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Context Info
Confidence 0.56
First Reported 1992
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 14.22
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI3) cytoplasm (TNNI3)
Anatomy Link Frequency
blood 2
chest 2
plasma 1
coronary artery 1
muscle 1
TNNI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Ultiva 3 98.56 Very High Very High Very High
Angina 29 98.36 Very High Very High Very High
Pain 13 95.44 Very High Very High Very High
cva 5 94.00 High High
depression 4 88.08 High High
ischemia 6 87.76 High High
nud 1 87.52 High High
Inflammation 24 61.92 Quite High
Inflammatory response 16 5.00 Very Low Very Low Very Low
Inflammatory marker 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 67 99.24 Very High Very High Very High
Angina 19 98.36 Very High Very High Very High
Injury 135 98.20 Very High Very High Very High
Bacterial Infection 24 97.80 Very High Very High Very High
Chronic Renal Failure 4 96.96 Very High Very High Very High
Death 29 96.12 Very High Very High Very High
Muscle Disease 4 96.00 Very High Very High Very High
Sepsis 14 95.92 Very High Very High Very High
Pyometra 240 95.64 Very High Very High Very High
Pain 13 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To investigate the value of cardiac troponin I (cTnI) levels in assessing myocardial protection by remifentanil precondition against myocardial injury induced by off-pump coronary artery bypass (OPCAB).
Spec (investigate) Regulation (value) of cTnI in coronary artery associated with injury and ultiva
1) Confidence 0.56 Published 2009 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Abstract Doc Link 19726290 Disease Relevance 0.10 Pain Relevance 0.17
Troponins are intracellular contractile-regulating proteins in muscle cells and the isoenzyme cTnI is specific for heart muscle.
Regulation (regulating) of cTnI in muscle
2) Confidence 0.41 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.37 Pain Relevance 0.17
Reference values for plasma cTnI in healthy dogs has (in two different studies using the same method as in the present study [13,14]) previously been determined to be < 0.5 ?
Spec (determined) Regulation (values) of cTnI in plasma
3) Confidence 0.36 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.70 Pain Relevance 0.05
The purpose of this study was to determine whether long-term and short-term changes in cardiac troponin T (cTnT) were associated with adverse cardiac events (ACEs) in patients with chronic kidney disease.
Regulation (changes) of cardiac troponin T in kidney associated with chronic renal failure
4) Confidence 0.26 Published 2005 Journal Am J Emerg Med Section Abstract Doc Link 16032613 Disease Relevance 0.42 Pain Relevance 0.05
The sera of patients with impaired renal function without any cardiac failure showed no increase in troponin T and troponin I values.
Neg (no) Regulation (values) of troponin I associated with myocardial infarction
5) Confidence 0.25 Published 1997 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 9368795 Disease Relevance 0.39 Pain Relevance 0.07
The correlation between troponin T and troponin I values was 0.91 for the total material and 0.94 for 48 patients with acute myocardial infarction.
Regulation (values) of troponin I associated with myocardial infarction
6) Confidence 0.25 Published 1997 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 9368795 Disease Relevance 0.42 Pain Relevance 0.10
METHODS: At baseline and 12 h to 24 h after enrollment in the Thrombolysis in Myocardial Infarction (TIMI)-11B trial, samples were collected for cTnI determination.
Regulation (collected) of cTnI
7) Confidence 0.23 Published 2000 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11092649 Disease Relevance 0.08 Pain Relevance 0
Diagnostic sensitivities of creatine kinase MB isoenzyme (CK-MB) and cTnI were evaluated retrospectively in 49 consecutive patients with proven MI.
Regulation (sensitivities) of cTnI associated with myocardial infarction
8) Confidence 0.23 Published 1992 Journal Clin. Chem. Section Abstract Doc Link 1424112 Disease Relevance 0.46 Pain Relevance 0.08
The median postoperative values of cTnI were significantly different among groups (Table 3).
Regulation (values) of cTnI
9) Confidence 0.23 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.58 Pain Relevance 0
This bitch had preoperative cTnI values of 0.7 ?
Regulation (values) of cTnI
10) Confidence 0.22 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.22 Pain Relevance 0
To evaluate the predictive value of cTnI for survival, an increased patient number is necessary since only two female dogs died of causes related to pyometra.
Regulation (value) of cTnI associated with pyometra
11) Confidence 0.22 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.22 Pain Relevance 0
In 49 patients admitted for AMI treated by thrombolysis, the comparative sensitivities of TnI c (threshold: 0.1 ng/ml) and of CKMB activity (threshold: 15 IU/l; CK > or = 100 Ul/l) were, at the first sampling on admission, 61% and 22% respectively (p = 0.0002) (average interval from onset of pain to first blood sampling: 3.4 +/- 1.3 hours).
Regulation (sensitivities) of TnI in blood associated with pain and myocardial infarction
12) Confidence 0.21 Published 1996 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 8678740 Disease Relevance 0.90 Pain Relevance 0.36
Of the 29 pts with normal cTnT and cTnI values, three developed AMI, which in two cases was fatal.
Regulation (values) of cTnI
13) Confidence 0.18 Published 1996 Journal G Ital Cardiol Section Body Doc Link 9036039 Disease Relevance 0 Pain Relevance 0
The finding of altered cTnT and cTnI values in the serum of our pts with unstable angina does not appear to be of prognostic value for future coronary events.


Regulation (values) of cTnI
14) Confidence 0.18 Published 1996 Journal G Ital Cardiol Section Body Doc Link 9036039 Disease Relevance 0 Pain Relevance 0
In 111 healthy blood donors, the reference range for cTnI levels on AxSYM was 0.0 to 0.4 microgram/L.
Regulation (range) of cTnI in blood
15) Confidence 0.17 Published 1999 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 10587695 Disease Relevance 0.40 Pain Relevance 0.07
This study set out to assess the accuracy and correlates of the cardiac troponin I (cTnI) assay in the diagnosis of non-ST-segment elevation MI, to determine how the assay accuracy and correlates vary by gender, and to explore the interaction between factors that may influence cTnI accuracy and affect gender differences in diagnosis.
Regulation (influence) of cTnI associated with myocardial infarction
16) Confidence 0.16 Published 2009 Journal Transl Res Section Abstract Doc Link 19840766 Disease Relevance 0.70 Pain Relevance 0.04
Cardiac-TnT values ranging from 0-0.17 mugr/L (Boehringer Mannheim) were considered normal, as were cTnI values ranging from 0 to 0.7 mugr/L (Stratus-Dade).
Regulation (values) of cTnI
17) Confidence 0.16 Published 1996 Journal G Ital Cardiol Section Body Doc Link 9036039 Disease Relevance 0 Pain Relevance 0
In two pts with altered cTnT and cTnI values, symptoms were controlled with medical therapy, while the remaining patient failed to respond to medical therapy and therefore underwent PTCA.
Regulation (values) of cTnI
18) Confidence 0.16 Published 1996 Journal G Ital Cardiol Section Body Doc Link 9036039 Disease Relevance 0 Pain Relevance 0
RESULTS: Of the 4,123 patients admitted, 893 (22%) had detectable cTnI values.
Regulation (values) of cTnI
19) Confidence 0.15 Published 2004 Journal J. Am. Coll. Cardiol. Section Body Doc Link 15028350 Disease Relevance 0 Pain Relevance 0
The biologist contacted for biological advice controlled cTnI with an Access II, which disclosed a value less than 0.04 ng/mL.
Regulation (controlled) of cTnI
20) Confidence 0.12 Published 2008 Journal Am J Emerg Med Section Abstract Doc Link 18926374 Disease Relevance 0.43 Pain Relevance 0.13

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