INT9548

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Context Info
Confidence 0.65
First Reported 1984
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 99
Total Number 101
Disease Relevance 50.86
Pain Relevance 9.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CHKB)
Anatomy Link Frequency
fibroblasts 5
oocytes 4
pericardial fluid 3
muscle 3
myocardium 2
CHKB (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 14 100.00 Very High Very High Very High
Angina 330 99.84 Very High Very High Very High
cva 64 99.58 Very High Very High Very High
Kinase C 235 99.36 Very High Very High Very High
Inflammation 142 98.64 Very High Very High Very High
tolerance 33 98.56 Very High Very High Very High
abdominal pain 19 97.72 Very High Very High Very High
Pain 70 97.08 Very High Very High Very High
depression 18 94.00 High High
medulla 58 93.72 High High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 55 100.00 Very High Very High Very High
Carcinoma 7 100.00 Very High Very High Very High
Lymphatic System Cancer 4 100.00 Very High Very High Very High
Gastrointestinal Stromal Tumor 1 100.00 Very High Very High Very High
Hyperlipidemia 43 99.88 Very High Very High Very High
Cv General 3 Under Development 194 99.84 Very High Very High Very High
Ectopic Pregnancy 760 99.80 Very High Very High Very High
Injury 150 99.80 Very High Very High Very High
Appendicitis 16 99.76 Very High Very High Very High
Myocardial Infarction 542 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The markers normally used include creatine kinase (CK), heart-fatty acid binding protein, myoglobin, TnI and ?
Gene_expression (include) of CK in heart
1) Confidence 0.65 Published 2008 Journal British Journal of Sports Medicine Section Body Doc Link PMC2564766 Disease Relevance 0.25 Pain Relevance 0.06
INVESTIGATIONS: Laboratory results showed elevated levels for bilirubin, CK, BUN, creatinine and low thrombocytes in patients 1 and 2.
Gene_expression (thrombocytes) of CK in thrombocytes
2) Confidence 0.63 Published 2010 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 20358494 Disease Relevance 0.10 Pain Relevance 0
INVESTIGATIONS: Laboratory results showed elevated levels for bilirubin, CK, BUN, creatinine and low thrombocytes in patients 1 and 2.
Gene_expression (levels) of CK in thrombocytes
3) Confidence 0.63 Published 2010 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 20358494 Disease Relevance 0.10 Pain Relevance 0
The supplemented group had lower CK and LDH levels following the exercise bout than the placebo condition.
Gene_expression (levels) of CK
4) Confidence 0.61 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0.14 Pain Relevance 0
While the expression of MSIs of GP and PGAM was the same in contracting-innervated and paralyzed-innervated muscle fibers, the expression of MSIs of CK and LDH in paralyzed-innervated muscle fibers was very slightly decreased as compared to their contracting-innervated controls.
Gene_expression (expression) of CK in muscle fibers associated with paralysis
5) Confidence 0.60 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.43 Pain Relevance 0.07
The expression of MSIs of CK, GP, PGAM, and LDH was always significantly increased in innervated as compared to noninnervated fibers.
Gene_expression (expression) of CK
6) Confidence 0.60 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.42 Pain Relevance 0.08
Western blood analysis was performed to determine fast and slow myosin and creatine kinase (CK) levels.
Gene_expression (levels) of CK in blood
7) Confidence 0.58 Published 2008 Journal British Journal of Sports Medicine Section Abstract Doc Link PMC2564766 Disease Relevance 0.26 Pain Relevance 0.09
Some indicators of muscle damage include increased levels of creatine kinase (CK), lactate dehydrogenase (LDH) and muscular soreness [7].
Gene_expression (levels) of CK in muscle
8) Confidence 0.55 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0.16 Pain Relevance 0
The levels of CK, and especially those of the myocardial specific isoform (CK-MB), have served as essential components for clinical decision in emergency rooms for over 25 years.
Gene_expression (levels) of CK-MB associated with emergencies
9) Confidence 0.53 Published 1999 Journal Rev Port Cardiol Section Abstract Doc Link 10661020 Disease Relevance 0.19 Pain Relevance 0
The levels of CK, and especially those of the myocardial specific isoform (CK-MB), have served as essential components for clinical decision in emergency rooms for over 25 years.
Gene_expression (levels) of CK associated with emergencies
10) Confidence 0.53 Published 1999 Journal Rev Port Cardiol Section Abstract Doc Link 10661020 Disease Relevance 0.19 Pain Relevance 0
Our studies demonstrate that in human muscle: (1) total enzymatic activities and the expression of MSIs of GP and PGAM are regulated by neuronal effect(s); (2) total enzymatic activities of CK, LDH, and AChE depend mainly on muscle contractile activity; and (3) MSIs of CK and LDH are regulated predominantly by neuronal factors and to a much lesser degree by muscle contractile activity.
Gene_expression (expression) of CK in muscle
11) Confidence 0.52 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.40 Pain Relevance 0.06
Laboratory examinations showed leukocytosis, a slightly elevated level of CRP, and normal CK levels.
Gene_expression (levels) of CK associated with leukocytosis
12) Confidence 0.50 Published 2000 Journal Rinsho Shinkeigaku Section Abstract Doc Link 11186911 Disease Relevance 0.91 Pain Relevance 0.30
Non-Q-wave MI was defined as the appearance of abnormal CK/CK-MB in the absence of Q-wave criteria.
Gene_expression (appearance) of CK-MB associated with myocardial infarction
13) Confidence 0.50 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 1.69 Pain Relevance 0.21
Non-Q-wave MI was defined as the appearance of abnormal CK/CK-MB in the absence of Q-wave criteria.
Gene_expression (appearance) of CK associated with myocardial infarction
14) Confidence 0.50 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 1.69 Pain Relevance 0.21
In UA/NSTEMI, the severity of the presenting chest pain, ischemic ST-T changes, post-MI angina, and elevated serum levels of CK-MB and of troponin T or I are markers of risk [1].
Gene_expression (levels) of CK-MB in chest associated with angina, arrhythmias 2 under development, cva and myocardial infarction
15) Confidence 0.50 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 1.22 Pain Relevance 0.35
In our current study, the median CK at 24 hours was somewhat higher in the three-exposure group compared to the two-exposure group (p<0.2).
Gene_expression (higher) of CK
16) Confidence 0.45 Published 2010 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2850854 Disease Relevance 0.09 Pain Relevance 0
His serial cardiac marker assays revealed an elevated total creatine kinase (CK) and 2 negative cardiac troponin levels.
Neg (negative) Gene_expression (levels) of CK
17) Confidence 0.44 Published 2010 Journal CJEM Section Abstract Doc Link 20078923 Disease Relevance 0.36 Pain Relevance 0.16
Endokinins are tachykinin peptides designated from a human preprotachykinin C (PPT-C, TAC4) gene and consist of endokinin A (EKA), endokinin B (EKB), endokinin C (EKC) and endokinin D (EKD).
Gene_expression (consist) of EKB
18) Confidence 0.43 Published 2007 Journal Brain Res. Section Abstract Doc Link 17655832 Disease Relevance 0.37 Pain Relevance 0.60
Serum CK rose faster and to a higher level than ALP after small bowel infarction (470 +/- 181 vs 196 + 28 IU/liter).
Gene_expression (rose) of CK in bowel associated with disorders of creatine metabolism and infarction
19) Confidence 0.43 Published 1984 Journal J. Surg. Res. Section Abstract Doc Link 6738045 Disease Relevance 0.98 Pain Relevance 0.08
The CK levels in women in the tubal pregnancy group were significantly higher than in the other four groups (P < 0.0001).
Gene_expression (levels) of CK associated with tubal pregnancy
20) Confidence 0.41 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.35 Pain Relevance 0.09

General Comments

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