INT95481

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2010
Negated 3
Speculated 6
Reported most in Abstract
Documents 48
Total Number 54
Disease Relevance 29.30
Pain Relevance 26.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
nerve 13
neurons 8
sensory neurons 6
bowel 6
forearm 4
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 277 100.00 Very High Very High Very High
Pain 263 100.00 Very High Very High Very High
agonist 55 100.00 Very High Very High Very High
nociceptor 26 100.00 Very High Very High Very High
b2 receptor 22 100.00 Very High Very High Very High
dorsal root ganglion 21 100.00 Very High Very High Very High
Peripheral nervous system 19 100.00 Very High Very High Very High
Analgesic 16 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 54 100.00 Very High Very High Very High
Hyperalgesia 48 99.90 Very High Very High Very High
Disease 85 99.82 Very High Very High Very High
Rheumatoid Arthritis 10 99.78 Very High Very High Very High
Headache 10 99.74 Very High Very High Very High
INFLAMMATION 206 99.64 Very High Very High Very High
Injury 100 99.46 Very High Very High Very High
Nervous System Injury 5 99.24 Very High Very High Very High
Abnormal Reflex 7 99.16 Very High Very High Very High
Neuropathic Pain 20 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the above results, our data suggest that the expression of TRPV1 is affected by both the intrinsic ageing and photoageing processes.
Regulation (affected) of Gene_expression (expression) of TRPV1 associated with aging
1) Confidence 0.62 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.21 Pain Relevance 0
In this study, we investigated the effect of acute UV irradiation on TRPV1 expression in human skin and the changes in TRPV1 mRNA and protein in intrinsic ageing and photoageing using human sun-protected (upper inner arm) and sun-exposed (forearm) skin of young and elderly subjects.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of TRPV1 in forearm associated with aging
2) Confidence 0.62 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.20 Pain Relevance 0.09
Good evidence suggests altered VR1 expression in various disease states.
Regulation (altered) of Gene_expression (expression) of VR1 associated with disease
3) Confidence 0.62 Published 2002 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 12109845 Disease Relevance 0.46 Pain Relevance 0.45
Combined, these findings imply an important role for aberrant TRPV1 expression in the development of neuropathic pain and hyperalgesia.
Regulation (role) of Gene_expression (expression) of TRPV1 associated with hyperalgesia and neuropathic pain
4) Confidence 0.62 Published 2004 Journal Eur. J. Biochem. Section Abstract Doc Link 15128291 Disease Relevance 0.75 Pain Relevance 0.49
In humans, disease-related changes in TRPV1 expression have already been described (e.g. inflammatory bowel disease and irritable bowel syndrome).
Regulation (changes) of Gene_expression (expression) of TRPV1 in bowel associated with inflammation, spastic colon and disease
5) Confidence 0.62 Published 2004 Journal Eur. J. Biochem. Section Abstract Doc Link 15128291 Disease Relevance 0.76 Pain Relevance 0.47
The mechanisms that regulate TRPV1 gene expression under pathological conditions are unknown but a better understanding of these pathways has obvious implications for rational drug development.
Regulation (regulate) of Gene_expression (expression) of TRPV1 gene
6) Confidence 0.62 Published 2004 Journal Eur. J. Biochem. Section Abstract Doc Link 15128291 Disease Relevance 0.73 Pain Relevance 0.46
We studied the effects of Ara C on human dorsal root ganglion (DRG) neurons, especially the expression and sensitivity of the ion channel TRPV1, which responds to noxious heat and capsaicin and is a key mediator of neuropathic pain.
Regulation (effects) of Gene_expression (expression) of TRPV1 in neurons associated with ganglion cysts, dorsal root ganglion, qutenza and neuropathic pain
7) Confidence 0.62 Published 2008 Journal J. Neurooncol. Section Abstract Doc Link 18414789 Disease Relevance 0.38 Pain Relevance 0.41
Changes in vanilloid receptor 1 (TRPV1) expression following lingual nerve injury.
Regulation (Changes) of Gene_expression (expression) of vanilloid receptor 1 in nerve associated with neuralgia and nervous system injury
8) Confidence 0.62 Published 2007 Journal Eur J Pain Section Title Doc Link 16542859 Disease Relevance 0.72 Pain Relevance 0.28
Using flow cytofluorometry we assessed how the cytotoxic effect of TRPV1 agonists depends on the TRPV1 expression level and concentrations of agonists.
Regulation (effect) of Gene_expression (expression) of TRPV1 associated with agonist
9) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.05 Pain Relevance 0.55
In humans, disease-related changes in TRPV1 expression have been described in inflammatory bowel disease, irritable bowel syndrome, cervical cancer and destrusor hyperreflexia [6-9].
Regulation (changes) of Gene_expression (expression) of TRPV1 in bowel associated with cervical cancer, inflammation, spastic colon, abnormal reflex and disease
10) Confidence 0.61 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 1.46 Pain Relevance 0.54
As a result, altered TRPV gene expression could play a role in the molecular diagnosis of various disease states.
Regulation (altered) of Gene_expression (expression) of TRPV gene associated with disease
11) Confidence 0.61 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 1.57 Pain Relevance 0.53
Next, we introduce the possible therapeutic approaches for the application of this receptor for treating migraine; these approaches include regulation of neurotransmitter release via the TRPV1 receptor, regulation of pain conduction pathways via the TRPV1 receptor, and the regulation of the expression of the TRPV1 receptor.
Regulation (regulation) of Gene_expression (expression) of TRPV1 receptor associated with pain, neurotransmitter and migraine
12) Confidence 0.58 Published 2009 Journal Brain Nerve Section Abstract Doc Link 19697884 Disease Relevance 0.98 Pain Relevance 0.94
TRPV1 expression and activity appear to be altered under pathophysiological conditions such as chronic cough and airway hypersensitivity, whereas TRPV4 single nucleotide polymorphisms (SNP) are associated with chronic obstructive pulmonary disease.
Regulation (altered) of Gene_expression (expression) of TRPV1 associated with pulmonary disease, hypersensitivity and cough
13) Confidence 0.56 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20639579 Disease Relevance 0.62 Pain Relevance 0
This partially contrasts with experimental data concerning the effect of estrogens on the expression of the TRPV genes.
Regulation (effect) of Gene_expression (expression) of TRPV
14) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 0 Pain Relevance 0
NT-3 effected a decrease in expression of the activated component of the signaling pathway linked to regulation of TRPV1 expression, phospho-p38 MAPK (Ji et al., 2002), in neurons ipsilateral to CCI.
Regulation (regulation) of Gene_expression (expression) of TRPV1 in neurons associated with eae
15) Confidence 0.53 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15659614 Disease Relevance 1.60 Pain Relevance 1.33
In this study, we investigated the effect of acute UV irradiation on TRPV1 expression in human skin and the changes in TRPV1 mRNA and protein in intrinsic ageing and photoageing using human sun-protected (upper inner arm) and sun-exposed (forearm) skin of young and elderly subjects.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of TRPV1 in forearm associated with aging
16) Confidence 0.45 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.20 Pain Relevance 0.09
In order to clarify the role of TRPV1 on the upper airway, we examined the localization and the expression of TRPV1 in human nasal mucosa.
Spec (examined) Regulation (localization) of Gene_expression (expression) of TRPV1 in upper
17) Confidence 0.45 Published 2006 Journal Rhinology Section Abstract Doc Link 16792172 Disease Relevance 0.27 Pain Relevance 0.26
So far, TRPV1 receptor expression was detected on neurons.
Regulation (detected) of Gene_expression (expression) of TRPV1 receptor in neurons
18) Confidence 0.45 Published 2010 Journal Neuroimmunomodulation Section Abstract Doc Link 19923855 Disease Relevance 0.60 Pain Relevance 0.18
We show that RA highly up-regulated the total and cell surface TRPV1 protein expression but the TRPV1 mRNA level was unaffected.
Regulation (regulated) of Gene_expression (expression) of TRPV1 associated with rheumatoid arthritis
19) Confidence 0.45 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19651168 Disease Relevance 0.71 Pain Relevance 0.17
Changes in vanilloid receptor 1 (TRPV1) expression following lingual nerve injury.
Regulation (Changes) of Gene_expression (expression) of TRPV1 in nerve associated with neuralgia and nervous system injury
20) Confidence 0.45 Published 2007 Journal Eur J Pain Section Title Doc Link 16542859 Disease Relevance 0.72 Pain Relevance 0.28

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