INT95482

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.94
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Akr1c2) cytoplasm (Akr1c2)
Anatomy Link Frequency
hypothalamus 1
hippocampus 1
frontal cortex 1
Akr1c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 4 97.48 Very High Very High Very High
narcan 1 94.88 High High
Opioid 6 93.84 High High
antagonist 1 93.28 High High
carbamazepine 3 91.52 High High
Morphine 3 87.48 High High
Desipramine 3 86.96 High High
Endep 2 82.56 Quite High
Endogenous opioid 1 79.12 Quite High
noradrenaline 1 77.64 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 99.64 Very High Very High Very High
Cognitive Disorder 2 95.88 Very High Very High Very High
Anxiety Disorder 3 95.00 High High
Stress 2 75.00 Quite High
Infection 1 67.08 Quite High
Interstitial Cystitis 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors hypothesized that if T's effects are mediated in part through actions of its 5alpha-reduced, nonaromatizable metabolite dihydrotestosterone (DHT) and/or its 3alpha-hydroxysteroid dehydrogenase reduced metabolite 3alpha-androstanediol (3alpha-diol) in the hippocampus, then T, DHT, and 3alpha-diol administration should produce similar behavioral effects concomitant with elevating T metabolites in the hippocampus.
Positive_regulation (mediated) of 3alpha-hydroxysteroid dehydrogenase in hippocampus associated with hippocampus
1) Confidence 0.50 Published 2004 Journal Behav. Neurosci. Section Abstract Doc Link 15598144 Disease Relevance 0.41 Pain Relevance 0.34
It is concluded that some psychotropic drugs may increase allopregnanolone synthesis by stimulating the activity of the enzyme, 3alpha-hydroxysteroid dehydrogenase, in the frontal cortex, and that this neurosteroid may be partly involved in the mechanism of action of the drugs under study.
Positive_regulation (stimulating) of 3alpha-hydroxysteroid dehydrogenase in frontal cortex associated with urological neuroanatomy
2) Confidence 0.46 Published 2000 Journal Pol J Pharmacol Section Abstract Doc Link 11334228 Disease Relevance 0.33 Pain Relevance 0.60
PI3, SERPINB4, CYP2C8, EFEMP2 and SEPP1 were decreased, and AKR1C2 and MKNK1 were increased in interstitial cystitis cases.
Positive_regulation (increased) of AKR1C2
3) Confidence 0.12 Published 2008 Journal J. Urol. Section Body Doc Link 18951569 Disease Relevance 0 Pain Relevance 0
In late pregnancy, activity of the allopregnanolone-synthesizing enzymes (5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase) was increased in the hypothalamus as was mRNA expression in the NTS and PVN.
Positive_regulation (increased) of 3alpha-hydroxysteroid dehydrogenase in hypothalamus
4) Confidence 0.09 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19458216 Disease Relevance 0.20 Pain Relevance 0.62

General Comments

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