INT9549

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Context Info
Confidence 0.47
First Reported 1990
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 13.61
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CHKB)
Anatomy Link Frequency
muscle 3
chest 3
muscle cell 1
upper 1
CHKB (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 235 99.66 Very High Very High Very High
Inflammation 16 98.94 Very High Very High Very High
Angina 61 98.36 Very High Very High Very High
abdominal pain 4 91.72 High High
ischemia 120 82.88 Quite High
Central nervous system 6 58.24 Quite High
tetrodotoxin 1 57.00 Quite High
agonist 21 53.04 Quite High
alcohol 8 47.68 Quite Low
visual analogue scale 15 30.80 Quite Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 19 100.00 Very High Very High Very High
Muscle Disease 17 100.00 Very High Very High Very High
Rupture 10 99.82 Very High Very High Very High
Cancer 82 99.40 Very High Very High Very High
Chlamydia Infection 4 99.10 Very High Very High Very High
Angina 52 98.36 Very High Very High Very High
Myalgia 72 98.24 Very High Very High Very High
Ectopic Pregnancy 190 98.18 Very High Very High Very High
Repression 20 97.96 Very High Very High Very High
Myocardial Infarction 205 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies demonstrate that in human muscle: (1) total enzymatic activities and the expression of MSIs of GP and PGAM are regulated by neuronal effect(s); (2) total enzymatic activities of CK, LDH, and AChE depend mainly on muscle contractile activity; and (3) MSIs of CK and LDH are regulated predominantly by neuronal factors and to a much lesser degree by muscle contractile activity.
Regulation (regulated) of CK in muscle
1) Confidence 0.47 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.37 Pain Relevance 0.06
For patients with EP, the degree of tubal distention, implantation site, and presence of tubal rupture did not affect the CK value, thereby limiting the clinical significance of this test.
Neg (not) Regulation (affect) of CK associated with rupture and ectopic pregnancy
2) Confidence 0.33 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.27 Pain Relevance 0.09
The trophoblast usually invades the muscle layer and maternal blood vessels are eroded, allowing muscle cell products such as CK to enter the circulation;26 therefore, increased serum CK levels are normal during EP.26,27 The pathology of arrested IUP and pelvic inflammatory disease are different, although both demonstrate no change in CK concentration.
Neg (no) Regulation (change) of CK in muscle cell associated with inflammation, chlamydia infection and ectopic pregnancy
3) Confidence 0.24 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.19 Pain Relevance 0.08
Creatine kinase (CK) values were also determined by LabCorp independent testing (Scottsdale, AZ).
Regulation (values) of CK
4) Confidence 0.23 Published 2010 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2850854 Disease Relevance 0.06 Pain Relevance 0
When CK-MB values were abnormal at baseline or up to 8 h, the patient was diagnosed as having an entry MI.
Regulation (values) of CK-MB associated with myocardial infarction
5) Confidence 0.22 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.34 Pain Relevance 0
Estimates of infarct size were obtained by using the peak CK-MB elevation values observed during the first 24 h after randomization and the distribution of a ratio formed by the peak value to the baseline values.
Regulation (values) of CK-MB
6) Confidence 0.22 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.56 Pain Relevance 0.16
For those with elevated CK-MB, more than two times the upper limit of normal within 8 h after randomization, and with a decrease in CK-MB of more than 50% from the previous peak value, reinfarction was defined as an elevation of the value of CK-MB at or after 8 h to more than two times the upper limit of normal (three times in the case of PTCA) and 75% more than the preceding trough CK-MB values.
Regulation (value) of CK-MB in upper
7) Confidence 0.22 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.41 Pain Relevance 0.13
There were no differences in serum CK values among the three groups at baseline.
Neg (no) Regulation (values) of CK
8) Confidence 0.22 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0.23 Pain Relevance 0
The supplement or timing of ingestion had no effect on serum CK at any time points.


Neg (no) Regulation (effect) of CK
9) Confidence 0.22 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0.28 Pain Relevance 0
Each sample in that set was corrected against an activity change of the frozen CK standard.
Regulation (change) of CK
10) Confidence 0.22 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0 Pain Relevance 0
Since previous studies have shown that Receptor Ck activation leads to the generation of the second messenger, phosphatidic acid (PA) [22] and since PA can be dephosphorylated by the enzyme phosphatidic acid phosphohydrolase (PAP) to give rise to diacylglycerol (DAG), which is an endogenous activator of protein kinase C (PKC) [25,26], we hypothesized that PA, DAG and PKC may be involved in the Receptor Ck dependent transcriptional regulation of c-myc, PPAR?
Regulation (regulation) of Ck associated with kinase c
11) Confidence 0.22 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0.30
The Receptor Ck-dependent down-regulation of hTERT mRNA expression observed in the present study may cooperate with the other repressive mechanisms operational in PBMCs in order to maintain appropriate low levels of telomerase in these cells.
Regulation (regulation) of Ck
12) Confidence 0.22 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.46 Pain Relevance 0
In order to assess the involvement of PKC in the Receptor Ck dependent regulation of the transcription of hTERT, c-myc and PPAR?
Regulation (regulation) of Ck associated with kinase c
13) Confidence 0.22 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.13 Pain Relevance 0.29
Role of c-myc in Receptor Ck dependent regulation of hTERT gene transcription
Regulation (regulation) of Ck
14) Confidence 0.22 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
This study found that the mean CK value was elevated to a level of 242.3 U/L at 24 hours.
Regulation (value) of CK
15) Confidence 0.20 Published 2010 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2850854 Disease Relevance 0.08 Pain Relevance 0
CK values in these subjects ranged from 55–174,260 with a mean of 36, 512.
Regulation (values) of CK
16) Confidence 0.20 Published 2010 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2850854 Disease Relevance 0.17 Pain Relevance 0
All centers had to determine the CK-MB values, at least when the total CK values were elevated.
Regulation (values) of CK
17) Confidence 0.19 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.72 Pain Relevance 0.18
In this context, Receptor Ck, a cell-surface receptor specific for the cholesterol moiety in lipoprotein particles [13], may be a good candidate for the regulation of hTERT transcription.
Regulation (regulation) of Ck
18) Confidence 0.13 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.50 Pain Relevance 0.03
Peak value of HVMLC1 was five times higher than CK peak value and eight times that of LD1.
Regulation (value) of CK
19) Confidence 0.10 Published 1994 Journal Cardiology Section Abstract Doc Link 8174143 Disease Relevance 0.86 Pain Relevance 0.41
Sensitivity of TnT, CK-MB, and H-FABP tests in the second time period (within 6-24 h of chest pain) were 100%, 90%, and 91% respectively.
Regulation (Sensitivity) of CK-MB in chest associated with angina
20) Confidence 0.09 Published 2006 Journal Heart Vessels Section Abstract Doc Link 17151819 Disease Relevance 1.21 Pain Relevance 0.62

General Comments

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