INT95492

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2011
Negated 0
Speculated 6
Reported most in Abstract
Documents 20
Total Number 26
Disease Relevance 12.68
Pain Relevance 10.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
neurons 5
cerebrospinal fluid 2
glomus 2
neuronal 1
plasma 1
Nefh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 322 100.00 Very High Very High Very High
substance P 14 100.00 Very High Very High Very High
Kinase C 5 100.00 Very High Very High Very High
hCN2 7 99.98 Very High Very High Very High
Morphine 5 99.88 Very High Very High Very High
cerebral cortex 5 99.84 Very High Very High Very High
HCN1 7 99.80 Very High Very High Very High
Multiple sclerosis 29 99.64 Very High Very High Very High
Trigeminal ganglion neurons 4 99.30 Very High Very High Very High
Lasting pain 7 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 447 100.00 Very High Very High Very High
Glomus Tumor 4 100.00 Very High Very High Very High
Middle Cerebral Artery Infarction 14 99.96 Very High Very High Very High
Demyelinating Disease 30 99.64 Very High Very High Very High
Pain 42 99.28 Very High Very High Very High
Optic Neuritis 33 98.76 Very High Very High Very High
Neuropathic Pain 53 98.72 Very High Very High Very High
Drug Induced Neurotoxicity 128 97.92 Very High Very High Very High
Recurrence 3 96.84 Very High Very High Very High
Frailty 21 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, 2 h after the last dose of morphine, the abundance of pNF-H was still increased (27%), which was followed (6-24 h) by down-regulation of pNF-H (5% increase at 6 h; 5% decrease at 12 h, and 29% decrease at 24 h).
Gene_expression (abundance) of pNF-H associated with morphine
1) Confidence 0.67 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.08 Pain Relevance 1.27
Therefore, the loss of neuronal pNF-H expression demonstrated in the current study may be causally linked to the decreased size profiles of DRG neurons and reduced sensory nerve conduction velocity, which are induced by chronic oxaliplatin treatment in rodent models [8,9,12].
Gene_expression (expression) of pNF-H in neurons associated with dorsal root ganglion
2) Confidence 0.65 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.59 Pain Relevance 0.12
The objectives of this study were (1) to determine how cerebrospinal fluid (CSF) neurofilament heavy chain (NfH(SM134) and NfH(SM135)) levels relate to clinical outcome in optic neuritis (ON) and multiple sclerosis (MS) relapse patients treated with high dose oral methylprednisolone; and (2) to correlate neurofilament and myelin basic protein (MBP) concentrations, particularly as the latter was previously associated with clinical disability.
Gene_expression (levels) of NfH in cerebrospinal fluid associated with multiple sclerosis, optic neuritis, neuritis and recurrence
3) Confidence 0.64 Published 2005 Journal Mult. Scler. Section Abstract Doc Link 16193890 Disease Relevance 0.75 Pain Relevance 0.46
The objectives of this study were (1) to determine how cerebrospinal fluid (CSF) neurofilament heavy chain (NfH(SM134) and NfH(SM135)) levels relate to clinical outcome in optic neuritis (ON) and multiple sclerosis (MS) relapse patients treated with high dose oral methylprednisolone; and (2) to correlate neurofilament and myelin basic protein (MBP) concentrations, particularly as the latter was previously associated with clinical disability.
Gene_expression (levels) of NfH in cerebrospinal fluid associated with multiple sclerosis, optic neuritis, neuritis and recurrence
4) Confidence 0.64 Published 2005 Journal Mult. Scler. Section Abstract Doc Link 16193890 Disease Relevance 0.75 Pain Relevance 0.46
Levels of S100B, ferritin and two neurofilament heavy chain phosphoforms (NfH(SM134) and NfH(SM135)) were analysed using ELISA technique.
Spec (analysed) Gene_expression (Levels) of NfH
5) Confidence 0.64 Published 2004 Journal Mult. Scler. Section Abstract Doc Link 15222688 Disease Relevance 1.17 Pain Relevance 1.09
When these platinum agents were ranked according to their effect on the number of pNF-H-immunoreactive DRG neurons, oxaliplatin had the greatest effect, followed by cisplatin and then carboplatin had the least.
Gene_expression (neurons) of pNF-H-immunoreactive in neurons associated with dorsal root ganglion
6) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.61 Pain Relevance 0.22
In addition, the size of pNF-H-immunoreactive neurons was altered by oxaliplatin treatment as evident from significant changes in mean cell body size (-45%, P < 0.0001), and in the percentages of neurons with large (>1750 ?
Gene_expression (neurons) of pNF-H-immunoreactive in cell body
7) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.48 Pain Relevance 0.24
Furthermore, the levels of mRNA expression of NF-H, NF-M, and NF-L genes were elevated consistently in CS(2)-treated groups.
Gene_expression (expression) of NF-H
8) Confidence 0.52 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17120161 Disease Relevance 0.09 Pain Relevance 0.08
In this paper, we report that neuronal pNF-H expression, as determined by RT97 immunohistochemistry of rat DRG tissue, was significantly reduced after oxaliplatin treatment.
Gene_expression (expression) of pNF-H in neuronal associated with dorsal root ganglion
9) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.95 Pain Relevance 0.26
The epitopes of the RT97 antibody are phosphorylated KSP repeats within the tail domain of phosphorylated neurofilament heavy subunit [16], which are expressed in a specific pattern in DRG tissue of healthy adult rats [17].
Gene_expression (expressed) of neurofilament heavy subunit in tail associated with dorsal root ganglion
10) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.51 Pain Relevance 0.22
Levels of NfH(SM135) at baseline and week 3 also strongly correlated with the MBP concentration.
Gene_expression (Levels) of NfH
11) Confidence 0.50 Published 2005 Journal Mult. Scler. Section Abstract Doc Link 16193890 Disease Relevance 1.00 Pain Relevance 0.66
Levels of S100B, ferritin and two neurofilament heavy chain phosphoforms (NfH(SM134) and NfH(SM135)) were analysed using ELISA technique.
Spec (analysed) Gene_expression (Levels) of NfH
12) Confidence 0.49 Published 2004 Journal Mult. Scler. Section Abstract Doc Link 15222688 Disease Relevance 1.16 Pain Relevance 1.09
The levels of NF-L and NF-H in serum significantly increased, while NF-M, alpha-tubulin, beta-tubulin and beta-actin contents remain unchanged.
Gene_expression (levels) of NF-H
13) Confidence 0.47 Published 2008 Journal Toxicology Section Abstract Doc Link 18177991 Disease Relevance 0.28 Pain Relevance 0.29
The contents of six cytoskeletal proteins (NF-L, NF-M, NF-H, alpha-tubulin, beta-tubulin, and beta-actin) in both fractions were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting.
Spec (determined) Gene_expression (contents) of NF-H
14) Confidence 0.43 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17043767 Disease Relevance 0.35 Pain Relevance 0.18
For that, we investigated the changes of CaM, CaMKII, protein kinase C (PKC) and polymerization ratios (PRs) of NF-L, NF-M and NF-H in cerebral cortex (CC, including total cortex and some gray), spinal cord (SC) and sciatic nerve (SN) of rats treated with HD at a dosage of 1.75 or 3.50 mmol/kg for 8 weeks (five times per week).
Spec (investigated) Gene_expression (changes) of NF-H in spinal cord associated with kinase c, sciatic nerve, cerebral cortex and spinal cord
15) Confidence 0.38 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18582483 Disease Relevance 0.19 Pain Relevance 0.77
Then, the contents of six cytoskeletal protein (NF-L, NF-M, NF-H, alpha-tubulin, beta-tubulin, and beta-actin) in both fractions were determined by immunoblotting.
Spec (determined) Gene_expression (contents) of NF-H
16) Confidence 0.37 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16474999 Disease Relevance 0.08 Pain Relevance 0.12
Compared with the control, the levels of NF-L, NF-M, NF-H, beta-actin, tau, MAP2 proteins decreased and the level of alpha-tubulin increased in high ACR group, the levels of alpha-tubulin, beta-tubulin and MAP2 increased in low ACR group.
Gene_expression (levels) of NF-H
17) Confidence 0.37 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.07
Rats were all killed after 8 weeks to evaluate the levels of neurofilament(NF)-L, NF-M, NF-H, beta-actin, alpha-tubulin, beta-tubulin, tau, MAP2 proteins in plasma using both SDS-PAGE and western blotting.
Gene_expression (levels) of NF-H in plasma
18) Confidence 0.37 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.06
Seven days after MCAo, NF-H positive axons appearing swollen and bulbous were present in the ischemic striatum and these axons were not surrounded by CNPase immunoreactivity (Fig. 4).
Gene_expression (present) of NF-H in striatum associated with middle cerebral artery infarction
19) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.68 Pain Relevance 0.04
The relative levels of six cytoskeletal proteins (NF-L, NF-M, NF-H, alpha-tubulin, beta-tubulin, and beta-actin) in both fractions were determined by immunoblotting.
Spec (determined) Gene_expression (levels) of NF-H
20) Confidence 0.32 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17447142 Disease Relevance 0.16 Pain Relevance 0.11

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