INT95494

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.48
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefm) cytoskeleton (Nefm)
Anatomy Link Frequency
vertebrae 2
brains 1
Nefm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 2 98.56 Very High Very High Very High
dorsal root ganglion 116 98.36 Very High Very High Very High
addiction 2 90.96 High High
imagery 2 84.64 Quite High
opiate 2 83.76 Quite High
Morphine 5 78.96 Quite High
narcan 3 75.00 Quite High
cerebral cortex 2 71.92 Quite High
withdrawal 1 65.12 Quite High
tolerance 1 59.44 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 116 98.36 Very High Very High Very High
Opiate Addiction 1 91.52 High High
Drug Induced Neurotoxicity 48 5.00 Very Low Very Low Very Low
Frailty 8 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 4 5.00 Very Low Very Low Very Low
Colon Cancer 4 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DRG: dorsal root ganglion; L5: lumbar vertebrae 5; NF-H: non-phospho-specific neurofilament heavy subunit; NF-M: non-phospho-specific neurofilament medium subunit; pNF-H: phosphorylated neurofilament heavy subunit.


Phosphorylation (phosphorylated) of NF-M in vertebrae associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.20 Pain Relevance 0.14
DRG: dorsal root ganglion; L5: lumbar vertebrae 5; NF-H: non-phospho-specific neurofilament heavy subunit; NF-M: non-phospho-specific neurofilament medium subunit; pNF-H: phosphorylated neurofilament heavy subunit.


Phosphorylation (phosphorylated) of neurofilament medium in vertebrae associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.20 Pain Relevance 0.14
Increased amounts of phosphorylated neurofilaments (pNF-H and pNF-M) are found in postmortem brains of opioid addicts.
Phosphorylation (phosphorylated) of pNF-M in brains associated with opioid
3) Confidence 0.11 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.09 Pain Relevance 0.80

General Comments

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