INT95495

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Context Info
Confidence 0.82
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 22
Disease Relevance 7.36
Pain Relevance 12.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
brains 9
tail 6
vertebrae 3
nerve 2
cerebral cortex 1
Nefh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 14 99.60 Very High Very High Very High
Opioid 41 99.50 Very High Very High Very High
addiction 27 99.36 Very High Very High Very High
opioid receptor 6 99.22 Very High Very High Very High
Morphine 29 99.16 Very High Very High Very High
dorsal root ganglion 580 98.94 Very High Very High Very High
Endogenous opioid 3 98.72 Very High Very High Very High
antagonist 3 97.58 Very High Very High Very High
narcan 9 96.96 Very High Very High Very High
opiate 27 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Morphine Dependence 3 99.36 Very High Very High Very High
Ganglion Cysts 580 98.94 Very High Very High Very High
Opiate Addiction 24 96.30 Very High Very High Very High
Drug Induced Neurotoxicity 240 94.28 High High
Cancer 10 88.28 High High
Peripheral Neuropathy 20 87.88 High High
Cretinism 2 81.64 Quite High
Intellectual Impairment 1 78.52 Quite High
Neurodegenerative Disease 10 69.44 Quite High
Thyroid Disease 2 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acute (10 mg/kg for 2 h) and chronic (2 x 10 mg/kg for 14 days) treatments with naloxone, an opioid receptor antagonist, did not alter pNF-H in the cerebral cortex, suggesting that the opioid receptors (probably the mu-type) modulating the phosphorylation state of NF-H are not tonically activated by endogenous opioids.
Phosphorylation (phosphorylation) of NF-H in cerebral cortex associated with antagonist, endogenous opioid, narcan, opioid receptor and cerebral cortex
1) Confidence 0.82 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.07 Pain Relevance 1.25
The results indicate that morphine addiction is associated with an aberrant hyperphophorylation of NF-H in the rat brain.
Phosphorylation (hyperphophorylation) of NF-H in brain associated with addiction and morphine
2) Confidence 0.82 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.16 Pain Relevance 1.18
The RT97 primary antibody employed in these studies recognises phosphorylated KSP repeats in the tail domain of phosphorylated neurofilament heavy subunit (pNF-H) [16].
Phosphorylation (phosphorylated) of neurofilament heavy subunit in tail
3) Confidence 0.79 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.89 Pain Relevance 0.30
The RT97 primary antibody employed in these studies recognises phosphorylated KSP repeats in the tail domain of phosphorylated neurofilament heavy subunit (pNF-H) [16].
Phosphorylation (phosphorylated) of neurofilament heavy subunit in tail
4) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.89 Pain Relevance 0.30
The epitopes of the RT97 antibody are phosphorylated KSP repeats within the tail domain of phosphorylated neurofilament heavy subunit [16], which are expressed in a specific pattern in DRG tissue of healthy adult rats [17].
Phosphorylation (phosphorylated) of neurofilament heavy subunit in tail associated with dorsal root ganglion
5) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.46 Pain Relevance 0.20
The RT97 primary antibody employed in these studies recognises phosphorylated KSP repeats in the tail domain of phosphorylated neurofilament heavy subunit (pNF-H) [16].
Phosphorylation (phosphorylated) of pNF-H in tail
6) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.90 Pain Relevance 0.31
The RT97 primary antibody employed in these studies recognises phosphorylated KSP repeats in the tail domain of phosphorylated neurofilament heavy subunit (pNF-H) [16].
Phosphorylation (phosphorylated) of pNF-H in tail
7) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.90 Pain Relevance 0.31
Increased amounts of phosphorylated neurofilaments (pNF-H and pNF-M) are found in postmortem brains of opioid addicts.
Phosphorylation (phosphorylated) of pNF-H in brains associated with opioid
8) Confidence 0.63 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.09 Pain Relevance 0.79
After treatment with oxaliplatin, phosphorylated neurofilament heavy subunit (pNF-H) immunoreactivity was reduced in neuronal cell bodies, but unchanged in nerve fibres, of the L5 DRG.
Phosphorylation (phosphorylated) of neurofilament heavy subunit in nerve associated with dorsal root ganglion
9) Confidence 0.61 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785764 Disease Relevance 0.51 Pain Relevance 0.26
DRG: dorsal root ganglion; L5: lumbar vertebrae 5; NF-H: non-phospho-specific neurofilament heavy subunit; NF-M: non-phospho-specific neurofilament medium subunit; pNF-H: phosphorylated neurofilament heavy subunit.


Phosphorylation (phosphorylated) of neurofilament heavy subunit in vertebrae associated with ganglion cysts and dorsal root ganglion
10) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.20 Pain Relevance 0.14
DRG: dorsal root ganglion; L5: lumbar vertebrae 5; NF-H: non-phospho-specific neurofilament heavy subunit; NF-M: non-phospho-specific neurofilament medium subunit; pNF-H: phosphorylated neurofilament heavy subunit.


Phosphorylation (phosphorylated) of neurofilament heavy subunit in vertebrae associated with ganglion cysts and dorsal root ganglion
11) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.19 Pain Relevance 0.14
After treatment with oxaliplatin, phosphorylated neurofilament heavy subunit (pNF-H) immunoreactivity was reduced in neuronal cell bodies, but unchanged in nerve fibres, of the L5 DRG.
Phosphorylation (phosphorylated) of pNF-H in nerve associated with dorsal root ganglion
12) Confidence 0.53 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785764 Disease Relevance 0.51 Pain Relevance 0.26
DRG: dorsal root ganglion; L5: lumbar vertebrae 5; NF-H: non-phospho-specific neurofilament heavy subunit; NF-M: non-phospho-specific neurofilament medium subunit; pNF-H: phosphorylated neurofilament heavy subunit.


Phosphorylation (phosphorylated) of pNF-H in vertebrae associated with ganglion cysts and dorsal root ganglion
13) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.19 Pain Relevance 0.14
In brains of opioid addicts, the density of phosphorylated NF-H was increased (43%) as well as the ratio of phosphorylated to nonphosphorylated NF-H forms (two-fold).
Phosphorylation (phosphorylated) of NF-H in brains associated with opioid
14) Confidence 0.35 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.95
Since opioid addiction was associated with hyperphosphorylation of neurofilament (NF) in postmortem human brains, this study was undertaken to assess the status of the cdk5/p35 complex and its relation with NF-H phosphorylation in brains of chronic opioid abusers.
Phosphorylation (phosphorylation) of NF-H in brains associated with addiction and opioid
15) Confidence 0.35 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.10 Pain Relevance 0.70
In brains of opioid addicts, the density of phosphorylated NF-H was increased (43%) as well as the ratio of phosphorylated to nonphosphorylated NF-H forms (two-fold).
Phosphorylation (phosphorylated) of NF-H in brains associated with opioid
16) Confidence 0.35 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.95
This downregulation and the aberrant hyperphosphorylation of NF-H proteins might have important consequences in the development of neural plasticity associated with opiate addiction in humans.
Phosphorylation (hyperphosphorylation) of NF-H in neural associated with addiction and opiate
17) Confidence 0.35 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.24 Pain Relevance 0.92
In brains of opioid addicts, the density of phosphorylated NF-H was increased (43%) as well as the ratio of phosphorylated to nonphosphorylated NF-H forms (two-fold).
Phosphorylation (nonphosphorylated) of NF-H in brains associated with opioid
18) Confidence 0.35 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.95
In these brains, phosphorylated NF-H significantly correlated with p35 (r=0.58) but not with cdk5 (r=0.03).
Phosphorylation (phosphorylated) of NF-H in brains
19) Confidence 0.35 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.94
In brains of opioid addicts, the density of phosphorylated NF-H was increased (43%) as well as the ratio of phosphorylated to nonphosphorylated NF-H forms (two-fold).
Phosphorylation (phosphorylated) of NF-H in brains associated with opioid
20) Confidence 0.35 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.95

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