INT95499

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 17
Disease Relevance 8.97
Pain Relevance 7.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
neuronal 5
nerves 2
Nefh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 3 99.40 Very High Very High Very High
tolerance 3 99.40 Very High Very High Very High
opiate 6 99.18 Very High Very High Very High
dorsal root ganglion 522 99.00 Very High Very High Very High
Morphine 15 98.34 Very High Very High Very High
cerebral cortex 6 95.60 Very High Very High Very High
Sciatic nerve 9 93.32 High High
Spinal cord 3 92.36 High High
Peripheral nervous system 9 91.20 High High
Neuritis 5 90.60 High High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 219 99.60 Very High Very High Very High
Ganglion Cysts 522 99.00 Very High Very High Very High
Diabetes Mellitus 71 98.94 Very High Very High Very High
Frailty 37 97.48 Very High Very High Very High
Toxicity 18 97.12 Very High Very High Very High
Optic Neuritis 5 90.60 High High
INFLAMMATION 1 90.08 High High
Demyelinating Disease 6 88.24 High High
Opiate Addiction 3 85.84 High High
Neuropathic Pain 23 83.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, 2 h after the last dose of morphine, the abundance of pNF-H was still increased (27%), which was followed (6-24 h) by down-regulation of pNF-H (5% increase at 6 h; 5% decrease at 12 h, and 29% decrease at 24 h).
Negative_regulation (down-regulation) of pNF-H associated with morphine
1) Confidence 0.59 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.08 Pain Relevance 1.27
Chronic morphine (10-100 mg/kg for 5 days) followed by opiate withdrawal resulted in a time-dependent decline in pNF-H (induction of tolerance).
Negative_regulation (decline) of pNF-H associated with tolerance, opiate, withdrawal and morphine
2) Confidence 0.59 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.09 Pain Relevance 1.25
Thus, 2 h after the last dose of morphine, the abundance of pNF-H was still increased (27%), which was followed (6-24 h) by down-regulation of pNF-H (5% increase at 6 h; 5% decrease at 12 h, and 29% decrease at 24 h).
Negative_regulation (down-regulation) of pNF-H associated with morphine
3) Confidence 0.43 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.08 Pain Relevance 1.27
Loss of pNF-H may be mechanistically linked to oxaliplatin-induced neuronal atrophy, and serves as a readily measureable endpoint of its neurotoxicity in the rat model.



Negative_regulation (Loss) of pNF-H in neuronal associated with drug induced neurotoxicity and frailty
4) Confidence 0.36 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785764 Disease Relevance 0.45 Pain Relevance 0.08
Loss of pNF-H may be mechanistically linked to oxaliplatin-induced neuronal atrophy and serves as readily measureable endpoints of oxaliplatin neurotoxicity in the rat model.


Negative_regulation (Loss) of pNF-H in neuronal associated with drug induced neurotoxicity and frailty
5) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.74 Pain Relevance 0.17
Oxaliplatin-induces loss of neuronal pNF-H immunoreactivity
Negative_regulation (loss) of pNF-H in neuronal
6) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.94 Pain Relevance 0.27
Therefore, the loss of neuronal pNF-H immunoreactivity was not associated with the loss of DRG cells or any generalised reduction of neuronal marker or neurofilament expression induced by oxaliplatin.
Negative_regulation (loss) of pNF-H in neuronal associated with dorsal root ganglion
7) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.75 Pain Relevance 0.31
The molecular mechanisms responsible for loss of pNF-H immunoreactivity induced by oxaliplatin are unclear and require further study.
Negative_regulation (loss) of pNF-H
8) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.58 Pain Relevance 0.12
The present study also demonstrated that the extent of loss of pNF-H immunoreactivity corresponded to the relative neurotoxicity of oxaliplatin, cisplatin and carboplatin.
Negative_regulation (loss) of pNF-H associated with drug induced neurotoxicity
9) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.62 Pain Relevance 0.26
We demonstrated that chronic oxaliplatin treatment was associated with a specific pattern of loss of pNF-H immunoreactivity in rat DRG tissue in the current study.
Negative_regulation (loss) of pNF-H associated with dorsal root ganglion
10) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.64 Pain Relevance 0.27
The loss of pNF-H immunoreactivity was evident visually from qualitative changes in the intensity of neuronal cell body immunostaining in DRG sections and by statistically significant reductions in the numbers and size of pNF-H-immunoreactive neurons in oxaliplatin-treated animals, confirmed in two independent experiments.
Negative_regulation (loss) of pNF-H in neuronal associated with dorsal root ganglion
11) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.69 Pain Relevance 0.30
These findings link the loss of pNF-H with the neurotoxicity of oxaliplatin, although its exact role in this toxicity remains to be elucidated.
Negative_regulation (loss) of pNF-H associated with toxicity and drug induced neurotoxicity
12) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.68 Pain Relevance 0.13
Levels of NfH(SM135) at baseline and week 3 also strongly correlated with the MBP concentration.
Negative_regulation (Levels) of NfH
13) Confidence 0.36 Published 2005 Journal Mult. Scler. Section Abstract Doc Link 16193890 Disease Relevance 1.00 Pain Relevance 0.66
The levels of neurofilaments (NFs) subunits (NF-L, NF-M and NF-H) in nerve tissues of 200 and 400mg/kg HD rats significantly decreased in both the supernatant and pellet fractions.
Negative_regulation (decreased) of NF-H in nerve
14) Confidence 0.33 Published 2008 Journal Toxicology Section Abstract Doc Link 18177991 Disease Relevance 0.08 Pain Relevance 0.25
Results showed that the three neurofilament (NF) subunits (NF-L, NF-M, NF-H) in both the pellet and the supernatant fraction decreased significantly (P < 0.01) in the high-dosing group, except for NF-M in the pellet. alpha-tubulin, beta-tubulin, and beta-actin increased significantly in the supernatant (P < 0.01), whereas both alpha-tubulin and beta-tubulin decreased significantly in the pellet (P < 0.01).
Negative_regulation (decreased) of NF-H
15) Confidence 0.27 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17043767 Disease Relevance 0.31 Pain Relevance 0.26
Compared with the control, the levels of NF-L, NF-M, NF-H, beta-actin, tau, MAP2 proteins decreased and the level of alpha-tubulin increased in high ACR group, the levels of alpha-tubulin, beta-tubulin and MAP2 increased in low ACR group.
Negative_regulation (decreased) of NF-H
16) Confidence 0.26 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.07
Therefore, we suggest that the axonal degeneration in STZ-induced diabetic rats was reflected by the distorted circularity and decreased NF-H, NF-M, and NF-L in the distal sural nerves of STZ-induced diabetic rats.
Negative_regulation (decreased) of NF-H in nerves associated with diabetes mellitus
17) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 1.00 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox