INT955

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Context Info
Confidence 0.78
First Reported 1975
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 126
Total Number 128
Disease Relevance 59.91
Pain Relevance 20.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH) extracellular region (GHRH) cell-cell signaling (GHRH)
Anatomy Link Frequency
plasma 12
pituitary 11
hypothalamus 4
fat 3
thyroid 3
GHRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 129 100.00 Very High Very High Very High
Neuropeptide 87 100.00 Very High Very High Very High
Clonidine 74 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
Opioid 29 99.90 Very High Very High Very High
anesthesia 14 99.78 Very High Very High Very High
Pain 126 99.74 Very High Very High Very High
narcan 18 99.52 Very High Very High Very High
Catecholamine 7 99.50 Very High Very High Very High
opiate 24 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Growth Hormone Deficiency 59 100.00 Very High Very High Very High
Cancer 579 99.96 Very High Very High Very High
Pituitary Cancer 136 99.96 Very High Very High Very High
Thyroid Disease 37 99.96 Very High Very High Very High
Acromegaly 236 99.92 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

8 99.92 Very High Very High Very High
Turner's Syndrome 45 99.80 Very High Very High Very High
Hyperplasia 45 99.80 Very High Very High Very High
Hypoglycemia 69 99.76 Very High Very High Very High
Chronic Renal Insufficiency 8 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Production of growth hormone-releasing hormone (GHRH) by an ectopic tumor was suspected and, after additional investigations, a large pancreatic tumor was detected and removed.
Gene_expression (Production) of GHRH associated with cancer and pancreatic cancer
1) Confidence 0.78 Published 1996 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 8551667 Disease Relevance 1.39 Pain Relevance 0.07
Preoperative evaluation revealed raised levels of somatomedin C and growth hormone.
Gene_expression (levels) of growth hormone
2) Confidence 0.78 Published 1996 Journal Headache Section Abstract Doc Link 8984093 Disease Relevance 0.51 Pain Relevance 0.25
Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) isoform expression in ectopic acromegaly.
Gene_expression (expression) of GHRH associated with acromegaly
3) Confidence 0.77 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 11453963 Disease Relevance 0.73 Pain Relevance 0.15
Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) isoform expression in ectopic acromegaly.
Gene_expression (expression) of GHRH associated with acromegaly
4) Confidence 0.77 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 11453963 Disease Relevance 0.73 Pain Relevance 0.15
We established that the tumour not only produced GHRH but the GHRH-receptor (GHRH-R) as well.
Gene_expression (produced) of GHRH associated with cancer
5) Confidence 0.77 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 11453963 Disease Relevance 0.99 Pain Relevance 0.17
We established that the tumour not only produced GHRH but the GHRH-receptor (GHRH-R) as well.
Gene_expression (produced) of GHRH associated with cancer
6) Confidence 0.77 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 11453963 Disease Relevance 0.99 Pain Relevance 0.17
The expression of a truncated splice variant that is unable to transduce GHRH signalling may be implicated in the less aggressive behaviour of well-differentiated endocrine tumours that produce GHRH compared with small-cell lung carcinomas that are very responsive to GHRH growth stimulation.
Gene_expression (produce) of GHRH in lung associated with lung cancer, cancer and aggression
7) Confidence 0.77 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 11453963 Disease Relevance 0.88 Pain Relevance 0.10
Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) isoform expression in ectopic acromegaly.
Gene_expression (expression) of Growth hormone associated with acromegaly
8) Confidence 0.77 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 11453963 Disease Relevance 0.73 Pain Relevance 0.15
We suggest that GHRH expression by this tumour and the presence of its receptor may be responsible for enhanced growth.
Gene_expression (expression) of GHRH associated with cancer
9) Confidence 0.77 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 11453963 Disease Relevance 0.88 Pain Relevance 0.15
Bronchial endocrine neoplasms causing acromegaly due to ectopic production of growth hormone (GH)-releasing hormone (GHRH) have been reported.
Gene_expression (production) of GHRH associated with acromegaly and cancer
10) Confidence 0.77 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 11453963 Disease Relevance 0.52 Pain Relevance 0.07
Bronchial endocrine neoplasms causing acromegaly due to ectopic production of growth hormone (GH)-releasing hormone (GHRH) have been reported.
Gene_expression (production) of growth hormone associated with acromegaly and cancer
11) Confidence 0.77 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 11453963 Disease Relevance 0.51 Pain Relevance 0.07
Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) isoform expression in ectopic acromegaly.
Gene_expression (expression) of GHRH associated with acromegaly
12) Confidence 0.77 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 11453963 Disease Relevance 0.73 Pain Relevance 0.15
According to the different studies considered, it may be concluded that GHRH testing has limited diagnostic usefulness in the clinical evaluation of acromegaly, but allows to discriminate acromegalic patients with ectopic production of GHRH from those with pituitary tumors.
Gene_expression (production) of GHRH in pituitary associated with acromegaly and pituitary cancer
13) Confidence 0.76 Published 1989 Journal Minerva Med. Section Abstract Doc Link 2566960 Disease Relevance 0.56 Pain Relevance 0.12
The heptapeptide growth hormone-releasing peptide-1 (GHRP-1), one of a series of recently synthesized small growth hormone (GH)-releasing peptides, was administered as an iv bolus (1 microgram/kg) to 15 (six prepubertal, nine pubertal) short but healthy children and adolescents and to eight juvenile patients with pituitary insufficiency (four with isolated growth hormone deficiency, two with multiple pituitary hormone deficiencies, one with partial GH deficiency and one with GH-releasing hormone (GHRH) deficiency).
Gene_expression (synthesized) of growth hormone in pituitary associated with growth hormone deficiency and hypopituitarism
14) Confidence 0.75 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8279223 Disease Relevance 0.18 Pain Relevance 0
Dermorphin- growth hormone releasing factor (GRF) hybrid peptides (Y-Tyr-D-Ala-Xaa-Gly-Tyr-Pro-Ser-NH2) were synthesized and tested for opioid activity and their ability to stimulate growth hormone (GH) secretion.
Gene_expression (synthesized) of GRF associated with opioid
15) Confidence 0.75 Published 1989 Journal Arzneimittelforschung Section Abstract Doc Link 2505781 Disease Relevance 0 Pain Relevance 0.14
We have studied the effect of oral clonidine, insulin hypoglycemia, and exercise on plasma hGH and GHRH levels in 31 healthy short-stature children.
Gene_expression (levels) of GHRH in plasma associated with hypoglycemia and clonidine
16) Confidence 0.75 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2106191 Disease Relevance 0.23 Pain Relevance 0.40
The study medication is a human growth hormone produced by recombinant DNA technology in a mammalian cell line (SaizenĀ® 8 mg click easy, solution for injection).
Gene_expression (produced) of growth hormone
17) Confidence 0.68 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2212629 Disease Relevance 0.44 Pain Relevance 0.32
Production of growth hormone-releasing hormone (GHRH) by an ectopic tumor was suspected and, after additional investigations, a large pancreatic tumor was detected and removed.
Gene_expression (Production) of hormone-releasing hormone associated with cancer and pancreatic cancer
18) Confidence 0.68 Published 1996 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 8551667 Disease Relevance 1.39 Pain Relevance 0.07
The peak elevation in plasma growth hormone that was produced by clonidine on the day the placebo was given was inhibited an average of 87% by the 2 mg dose of MK-912 (p less than 0.01).
Gene_expression (produced) of growth hormone in plasma associated with clonidine
19) Confidence 0.68 Published 1989 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2568210 Disease Relevance 0.28 Pain Relevance 0.74
The growth of 52 growth hormone-deficient children treated with synthetic human growth hormone was analyzed.
Gene_expression (synthetic) of growth hormone
20) Confidence 0.67 Published 1991 Journal Am. J. Dis. Child. Section Abstract Doc Link 2058608 Disease Relevance 0 Pain Relevance 0

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