INT9550

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 113
Total Number 116
Disease Relevance 86.79
Pain Relevance 10.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI3) cytoplasm (TNNI3)
Anatomy Link Frequency
chest 8
blood 7
plasma 5
heart 5
filament 2
TNNI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 304 99.84 Very High Very High Very High
Angina 356 99.52 Very High Very High Very High
anesthesia 37 99.12 Very High Very High Very High
Inflammatory marker 43 98.02 Very High Very High Very High
imagery 118 97.88 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 9 97.64 Very High Very High Very High
Migraine 1 96.56 Very High Very High Very High
analgesia 1 96.00 Very High Very High Very High
Opioid 1 95.60 Very High Very High Very High
Inflammatory response 151 94.16 High High
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 465 100.00 Very High Very High Very High
Necrosis 223 100.00 Very High Very High Very High
Urological Neuroanatomy 112 100.00 Very High Very High Very High
Thrombosis 34 100.00 Very High Very High Very High
Myocardial Infarction 481 99.92 Very High Very High Very High
Bacterial Infection 208 99.88 Very High Very High Very High
INFLAMMATION 424 99.84 Very High Very High Very High
Pyometra 2040 99.78 Very High Very High Very High
Heart Murmurs 34 99.76 Very High Very High Very High
Syndrome 78 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: This work describes the degradation products of troponin I in HOCM patients undergoing PTSMA.
Gene_expression (products) of troponin I
1) Confidence 0.78 Published 2009 Journal Cardiology Section Body Doc Link 19571537 Disease Relevance 0.07 Pain Relevance 0
TnI was detected relatively early after the onset of chest pain (4.3 +/- 2.1 h, mean +/- SD); the peak occurred after 12.2 +/- 4.6 h in a population that had undergone fibrinolysis.
Gene_expression (detected) of TnI in chest associated with angina
2) Confidence 0.77 Published 1993 Journal Clin. Chem. Section Abstract Doc Link 8504566 Disease Relevance 0.52 Pain Relevance 0.18
Finally, among the spectrum of sarcomeric contractile protein disease, idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations [33].


Gene_expression (expression) of cardiac troponin I associated with restrictive cardiomyopathy and disease
3) Confidence 0.75 Published 2010 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2848131 Disease Relevance 1.13 Pain Relevance 0.14
Detectable cTnI levels were not associated with presence of SIRS (Fisher's exact test).


Gene_expression (Detectable) of cTnI associated with systemic inflammatory response syndrome
4) Confidence 0.71 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 0.96 Pain Relevance 0
We used a cardiospecific enzymoimmunometric assay to measure cardiac troponin I (cTnI) in samples serially drawn from 78 patients with acute myocardial infarction (AMI), 7 patients with unstable angina (Braunwald class III), 22 multi-traumatized patients, and in 30 athletes after eccentric exercise, as well as in 101 non-traumatic chest pain patients on admission to the emergency department. cTnI assay crossreactivity with crude human skeletal muscle homogenates was < 0.1%. cTnI could not be detected in athletes or multi-traumatized patients except for 2 trauma patients with myocardial damage.
Neg (not) Gene_expression (detected) of cTnI in skeletal muscle associated with angina, emergencies, injury and myocardial infarction
5) Confidence 0.68 Published 1996 Journal Clin. Chim. Acta Section Abstract Doc Link 8646813 Disease Relevance 1.17 Pain Relevance 0.36
Clinical variables upon admission, particularly vasopressor requirement, did not correlate with cTnI levels.
Gene_expression (levels) of cTnI
6) Confidence 0.67 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0.53 Pain Relevance 0
Among elderly (older than 65 years) patients (n = 49) with elevated cTnI levels, the 28-day mortality rate was 10/15 patients (66.7%), while the mortality rate among elderly patients with normal cTnI levels was only 4/34 patients (11.8%).
Gene_expression (levels) of cTnI
7) Confidence 0.67 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0 Pain Relevance 0
Among elderly (older than 65 years) patients (n = 49) with elevated cTnI levels, the 28-day mortality rate was 10/15 patients (66.7%), while the mortality rate among elderly patients with normal cTnI levels was only 4/34 patients (11.8%).
Gene_expression (levels) of cTnI
8) Confidence 0.67 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0.05 Pain Relevance 0
Patients who died had higher cTnI levels (p < 0.001), were significantly older (p = 0.001), had greater APACHE II scores (p = 0.001) and longer duration of mechanical ventilation (p < 0.001).
Gene_expression (levels) of cTnI
9) Confidence 0.67 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0.45 Pain Relevance 0
Elevated cTnI levels were not found to be an independent predictor of mortality regardless of APACHE II score (OR 2.8, 95% CI 0.87–9.2, p = 0.085).
Gene_expression (levels) of cTnI
10) Confidence 0.67 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0.15 Pain Relevance 0
A study in emergency department patients has shown that there is a significant correlation between cTnI elevation and outcome.
Gene_expression (elevation) of cTnI associated with emergencies
11) Confidence 0.67 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0.45 Pain Relevance 0
Our observation that cTnI elevation is not an independent predictor of mortality is not surprising because troponin reflects a single system malfunction while the multivariable APACHE II reflects several highly relevant systems in the context of critically ill patients.
Gene_expression (elevation) of cTnI associated with critical illness
12) Confidence 0.67 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0.52 Pain Relevance 0
While some suggested that cTnI levels correlate with myocardial damage and poor outcome, others could not confirm this association [6,13-17].
Gene_expression (levels) of cTnI
13) Confidence 0.67 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 1.05 Pain Relevance 0
TnI disappearance was generally observed between 5 and 9 days after the onset of chest pain.
Gene_expression (disappearance) of TnI in chest associated with angina
14) Confidence 0.67 Published 1993 Journal Clin. Chem. Section Abstract Doc Link 8504566 Disease Relevance 0.54 Pain Relevance 0.19
We produced eight IgG monoclonal antibodies against human cardiac troponin-I (cTnI) and tested them against human and animal (canine, bovine, and rabbit) troponins.
Gene_expression (produced) of cardiac troponin-I
15) Confidence 0.66 Published 1992 Journal Clin. Chem. Section Abstract Doc Link 1424112 Disease Relevance 0.27 Pain Relevance 0
We produced eight IgG monoclonal antibodies against human cardiac troponin-I (cTnI) and tested them against human and animal (canine, bovine, and rabbit) troponins.
Gene_expression (produced) of cTnI
16) Confidence 0.66 Published 1992 Journal Clin. Chem. Section Abstract Doc Link 1424112 Disease Relevance 0.27 Pain Relevance 0
Furthermore we ruled out relevant CAD as an alternative cause for cTnI elevation in the majority of the cTnI-positive patients.
Gene_expression (elevation) of cTnI associated with coronary artery disease
17) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815772 Disease Relevance 1.13 Pain Relevance 0
Nevertheless, it should be pointed out that this calculation did not refer to the main objective of the study, which was to compare the cTnI thresholds among groups.
Gene_expression (thresholds) of cTnI
18) Confidence 0.66 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.85 Pain Relevance 0.03
Measurements of cardiac troponin I concentration
Gene_expression (concentration) of cardiac troponin I
19) Confidence 0.66 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.27 Pain Relevance 0.08
Patients with increased risk of postoperative cardiac morbidity and mortality or of cTnI release (n = 475 patients, 17%) were excluded: emergency surgery in <24 hours (n = 86 patients, 3%), reoperative procedures (n = 58 patients, 2%), recent history (<4 weeks) of acute myocardial infarction and abnormal preoperative cTnI values >0.6 ng/ml (n = 101 patients, 4%), and various other surgical procedures (n = 230 patients, 8%) including valve repair and aortic valve plus mitral valve replacement.
Gene_expression (values) of cTnI in mitral valve associated with emergencies and myocardial infarction
20) Confidence 0.66 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.20 Pain Relevance 0

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