INT95500

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 4.45
Pain Relevance 12.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
cerebral cortex 3
NAc 2
plasma 1
neurons 1
nerve 1
Nefh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 4 99.84 Very High Very High Very High
antagonist 5 99.80 Very High Very High Very High
gABA 10 99.72 Very High Very High Very High
Morphine 40 99.68 Very High Very High Very High
cerebral cortex 10 99.68 Very High Very High Very High
cva 1 99.60 Very High Very High Very High
opioid receptor 8 99.58 Very High Very High Very High
Nucleus accumbens 14 99.36 Very High Very High Very High
Neuritis 18 99.28 Very High Very High Very High
Opioid 13 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 2 99.60 Very High Very High Very High
Optic Neuritis 18 99.28 Very High Very High Very High
Prolapse 1 99.02 Very High Very High Very High
Cluster Headache 1 98.36 Very High Very High Very High
Motor Neuron Diseases 1 98.22 Very High Very High Very High
Demyelinating Disease 13 97.56 Very High Very High Very High
Middle Cerebral Artery Infarction 14 97.44 Very High Very High Very High
Cv Unclassified Under Development 7 97.08 Very High Very High Very High
Opiate Addiction 7 92.68 High High
Drug Induced Neurotoxicity 3 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, 2 h after the last dose of morphine, the abundance of pNF-H was still increased (27%), which was followed (6-24 h) by down-regulation of pNF-H (5% increase at 6 h; 5% decrease at 12 h, and 29% decrease at 24 h).
Positive_regulation (increase) of pNF-H associated with morphine
1) Confidence 0.50 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.08 Pain Relevance 1.27
Acute morphine (30 mg/kg, 2 h) induced a marked increase in the immunodensity of pNF-H in the cerebral cortex (93%).
Positive_regulation (increase) of pNF-H in cerebral cortex associated with cerebral cortex and morphine
2) Confidence 0.50 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.09 Pain Relevance 1.09
The acute (10 mg/kg for 2 h) and chronic (2 x 10 mg/kg for 14 days) treatments with naloxone, an opioid receptor antagonist, did not alter pNF-H in the cerebral cortex, suggesting that the opioid receptors (probably the mu-type) modulating the phosphorylation state of NF-H are not tonically activated by endogenous opioids.
Neg (not) Positive_regulation (alter) of pNF-H in cerebral cortex associated with antagonist, endogenous opioid, narcan, opioid receptor and cerebral cortex
3) Confidence 0.50 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.07 Pain Relevance 1.28
The acute (10 mg/kg for 2 h) and chronic (2 x 10 mg/kg for 14 days) treatments with naloxone, an opioid receptor antagonist, did not alter pNF-H in the cerebral cortex, suggesting that the opioid receptors (probably the mu-type) modulating the phosphorylation state of NF-H are not tonically activated by endogenous opioids.
Neg (not) Positive_regulation (activated) of NF-H in cerebral cortex associated with antagonist, endogenous opioid, narcan, opioid receptor and cerebral cortex
4) Confidence 0.47 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.06 Pain Relevance 1.25
Except for that of NF-M in CC, the PRs of NF-L, NF-M and NF-H were also elevated in nerve tissues, which was consistent with the activation of protein kinases.
Positive_regulation (elevated) of NF-H in nerve
5) Confidence 0.39 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18582483 Disease Relevance 0.13 Pain Relevance 0.91
NfH(SM134) and the NfH(SM134:SM135) were significantly elevated in subjects with ON compared to controls.
Positive_regulation (elevated) of NfH associated with neuritis
6) Confidence 0.38 Published 2004 Journal Mult. Scler. Section Abstract Doc Link 15222688 Disease Relevance 1.15 Pain Relevance 1.11
Based on this cutoff, a significantly higher proportion of patients with amyotrophic lateral sclerosis, space-occupying lesions, disc prolapse and subarachnoid haemorrhage had pathologically elevated NfH(SMI35) levels compared to patients with cluster headache or demyelinating disease.A new nomenclature is proposed to facilitate the comparison between ELISA, immunoblotting and immunocytochemistry.
Positive_regulation (elevated) of NfH in lateral associated with cluster headache, cv general 4 under development, prolapse, cva, demyelinating disease and motor neuron diseases
7) Confidence 0.36 Published 2003 Journal J. Immunol. Methods Section Abstract Doc Link 12957406 Disease Relevance 0.49 Pain Relevance 0.15
NfH(SM134) and the NfH(SM134:SM135) were significantly elevated in subjects with ON compared to controls.
Positive_regulation (elevated) of NfH associated with neuritis
8) Confidence 0.33 Published 2004 Journal Mult. Scler. Section Abstract Doc Link 15222688 Disease Relevance 1.14 Pain Relevance 1.10
In brains of opioid addicts, the density of phosphorylated NF-H was increased (43%) as well as the ratio of phosphorylated to nonphosphorylated NF-H forms (two-fold).
Positive_regulation (increased) of NF-H in brains associated with opioid
9) Confidence 0.30 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12637947 Disease Relevance 0.15 Pain Relevance 0.95
Treatment with rhEPO did not significantly preserve NF-H positive axons compared with the saline treatment 7 days after MCAo (Fig. 4).
Neg (not) Positive_regulation (preserve) of NF-H associated with middle cerebral artery infarction
10) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.61 Pain Relevance 0.05
In the NAc shell, morphine administration resulted in upregulation of caspace 9, NF-kappaB, NF-H, tau, GABA-A delta subunit, FGFR1, Ggamma2, synuclein 1, syntaxin 5 and 13, GRK5, and c-fos mRNAs.
Positive_regulation (resulted) of NF-H in NAc associated with nucleus accumbens, gaba and morphine
11) Confidence 0.23 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.08 Pain Relevance 1.12
In the NAc shell, morphine administration resulted in upregulation of caspace 9, NF-kappaB, NF-H, tau, GABA-A delta subunit, FGFR1, Ggamma2, synuclein 1, syntaxin 5 and 13, GRK5, and c-fos mRNAs.
Positive_regulation (upregulation) of NF-H in NAc associated with nucleus accumbens, gaba and morphine
12) Confidence 0.15 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.08 Pain Relevance 1.12
In no cases were CGRP- or TRPV1-immunoreactive or IB4-binding neurons not likewise immunoreactive for NF-H.
Neg (not) Positive_regulation (immunoreactive) of NF-H in neurons associated with calcitonin gene-related peptide
13) Confidence 0.15 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.07 Pain Relevance 0.81
Rats were all killed after 8 weeks to evaluate the levels of neurofilament(NF)-L, NF-M, NF-H, beta-actin, alpha-tubulin, beta-tubulin, tau, MAP2 proteins in plasma using both SDS-PAGE and western blotting.
Positive_regulation (levels) of NF-H in plasma
14) Confidence 0.14 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.06

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