INT95503

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 2
Total Number 6
Disease Relevance 2.23
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
nerve 2
neurons 2
neuronal 1
cerebral cortex 1
Nefh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 99.80 Very High Very High Very High
dorsal root ganglion 290 99.68 Very High Very High Very High
cerebral cortex 2 99.68 Very High Very High Very High
opioid receptor 2 99.58 Very High Very High Very High
narcan 3 99.18 Very High Very High Very High
Endogenous opioid 1 93.56 High High
Morphine 5 87.60 High High
Pain 5 86.00 High High
tolerance 1 85.84 High High
withdrawal 1 83.04 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 290 99.68 Very High Very High Very High
Cancer 5 87.68 High High
Peripheral Neuropathy 10 87.28 High High
Opiate Addiction 1 70.08 Quite High
Body Weight 5 44.40 Quite Low
Drug Induced Neurotoxicity 120 25.00 Low Low
Frailty 20 5.00 Very Low Very Low Very Low
Toxicity 10 5.00 Very Low Very Low Very Low
Neuropathic Pain 10 5.00 Very Low Very Low Very Low
Colon Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although there was no change in the numbers of NF-H-immunoreactive neurons, their size was significantly altered by oxaliplatin as evident by changes in their mean cell body area (-28%; P = 0.0033), and in the percentages of large (>1750 ?
Neg (no) Regulation (change) of NF-H in neurons
1) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.34 Pain Relevance 0.17
The acute (10 mg/kg for 2 h) and chronic (2 x 10 mg/kg for 14 days) treatments with naloxone, an opioid receptor antagonist, did not alter pNF-H in the cerebral cortex, suggesting that the opioid receptors (probably the mu-type) modulating the phosphorylation state of NF-H are not tonically activated by endogenous opioids.
Neg (not) Regulation (alter) of pNF-H in cerebral cortex associated with antagonist, endogenous opioid, narcan, opioid receptor and cerebral cortex
2) Confidence 0.27 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335049 Disease Relevance 0.07 Pain Relevance 1.28
Non-phospho-specific NF-H immunoreactivity was present in nerve fibres and many neuronal cell bodies of all sizes (Figure 3) accounting for >95% of the overall population of DRG neurons in both control and oxaliplatin-treated animals (0%; P = 0.93).
Regulation (immunoreactivity) of NF-H in neurons associated with dorsal root ganglion
3) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.40 Pain Relevance 0.20
After treatment with oxaliplatin, phosphorylated neurofilament heavy subunit (pNF-H) immunoreactivity was reduced in neuronal cell bodies, but unchanged in nerve fibres, of the L5 DRG.
Regulation (immunoreactivity) of neurofilament heavy subunit in nerve associated with dorsal root ganglion
4) Confidence 0.26 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785764 Disease Relevance 0.51 Pain Relevance 0.26
After treatment with oxaliplatin, phosphorylated neurofilament heavy subunit (pNF-H) immunoreactivity was reduced in neuronal cell bodies, but unchanged in nerve fibres, of the L5 DRG.
Regulation (immunoreactivity) of pNF-H in nerve associated with dorsal root ganglion
5) Confidence 0.23 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785764 Disease Relevance 0.51 Pain Relevance 0.25
Finally we compared the effect of different chemotherapeutic agents on neuronal pNF-H immunoreactivity in rat DRG tissue.
Regulation (immunoreactivity) of pNF-H in neuronal associated with dorsal root ganglion
6) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.39 Pain Relevance 0.19

General Comments

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